Microvesicles in vascular homeostasis and diseases

Victoria C. Ridger; Chantal M. Boulanger; Anne Angelillo-Scherrer; Lina Badimon; Olivier Blanc-Brude; Marie-Luce Bochaton-Piallat; Eric Boilard; Edit I. Buzas; Andreas Caporali; Francoise Dignat-George; Paul C. Evans; Romaric Lacroix; Esther Lutgens; Daniel F. J. Ketelhuth; Rienk Nieuwland; Florence Toti; Jose Tuñon; Christian Weber; Imo E. Hoefer; Gregory Y. H. Lip; Nikos Werner; Eduard Shantsila; Hugo ten Cate; Mark Thomas; Paul Harrison

doi:10.1160/TH16-12-0943

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2017; 117(07): 1296-1316
DOI: 10.1160/TH16-12-0943

Position Paper

Schattauer GmbH

Microvesicles in vascular homeostasis and diseases

Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology

Victoria C. Ridger^*

¹Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health and the INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, UK

,

Chantal M. Boulanger^*

²INSERM UMR-S 970, Paris Cardiovascular Research Center – PARCC, Paris, France

³Université Paris Descartes, Sorbonne Paris Cité, Paris, France

,

Anne Angelillo-Scherrer

⁴Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

⁵Department of Clinical Research, University of Bern, Bern, Switzerland

,

Lina Badimon

⁶Cardiovascular Research Center (CSIC-ICCC), IIB-Sant Pau, Barcelona, Spain

⁷Cardiovascular Research Chair, UAB, Barcelona, Spain

,

Olivier Blanc-Brude

²INSERM UMR-S 970, Paris Cardiovascular Research Center – PARCC, Paris, France

³Université Paris Descartes, Sorbonne Paris Cité, Paris, France

,

Marie-Luce Bochaton-Piallat

⁸Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland

,

Eric Boilard

⁹Centre de Recherche du CHU de Québec, Université Laval, Department of Infectious diseases and Immunity, Quebec City, Quebec, Canada

,

Edit I. Buzas

¹⁰Semmelweis University, Department of Genetics, Cell- and Immunobiology, Budapest, Hungary

,

Andreas Caporali

¹¹University/British Heart Foundation Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK

,

Francoise Dignat-George

¹²Aix-Marseille University, INSERM, VRCM, UMR-S1076, UFR de Pharmacie, Marseille, France

¹³Department of Hematology and Vascular Biology, CHU La Conception, APHM, Marseille, France

,

Paul C. Evans

¹Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine, Dentistry and Health and the INSIGNEO Institute for In Silico Medicine, University of Sheffield, Sheffield, UK

,

Romaric Lacroix

¹²Aix-Marseille University, INSERM, VRCM, UMR-S1076, UFR de Pharmacie, Marseille, France

¹³Department of Hematology and Vascular Biology, CHU La Conception, APHM, Marseille, France

,

Esther Lutgens

¹⁴Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands

¹⁵Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany

,

Daniel F. J. Ketelhuth

¹⁶Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

,

Rienk Nieuwland

¹⁷Laboratory of Experimental Clinical Chemistry, Vesicle Observation Center, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

,

Florence Toti

¹⁸Faculty of Pharmacy, UMR CNRS 7213, University of Strasbourg, Strasbourg, France

,

Jose Tuñon

¹⁹IIS-Fundación Jiménez Díaz, Madrid, Spain

²⁰Autónoma University, Madrid, Spain

,

Christian Weber

¹⁵Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany

²¹Cardiovascular Research Institute Maastricht (CARIM), 6229 ER Maastricht, The Netherlands

,

Imo E. Hoefer

²²Laboratory of Clinical Chemistry and Hematology, UMC Utrecht, Netherlands

› Author AffiliationsREVIEWERS:

Gregory Y. H. Lip review coordinator

²³Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK

,

Nikos Werner

²⁴Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn, Germany

,

Eduard Shantsila

²³Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK

,

Hugo ten Cate

²⁵UNS 50, University Medical Center, Maastricht, The Netherlands

,

Mark Thomas

²³Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK

,

Paul Harrison

²⁶Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

› Author Affiliations

Abstract

Summary

Microvesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as “microparticles”. There is mounting evidence revealing a role for microvesicles in intercellular communication, with particular relevance to hemostasis and vascular biology. Coupled with this, the potential of microvesicles as meaningful biomarkers is under intense investigation. This Position Paper will summarise the current knowledge on the mechanisms of formation and composition of microvesicles of endothelial, platelet, red blood cell and leukocyte origin. This paper will also review and discuss the different methods used for their analysis and quantification, will underline the potential biological roles of these vesicles with respect to vascular homeostasis and thrombosis and define important themes for future research.

Keywords

Atherothrombosis - cell-cell interactions - inflammatory mediators - macrophage

Full Text

References

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