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Thromb Haemost 2011; 105(S 06): S75-S81
DOI: 10.1160/THS10-12-0769
DOI: 10.1160/THS10-12-0769
Thrombosis and Haemostasis Supplement
Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors
Weitere Informationen
Publikationsverlauf
Received:
02. Dezember 2010
Accepted after minor revision:
07. Januar 2011
Publikationsdatum:
06. Dezember 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/2011S06/lookinside/thumbnails/10-1160-ths10-12-0769-1.jpg)
Summary
The important role of the P2Y12 receptor in amplification of platelet activation and associated responses and the limitations associated with clopidogrel therapy have led to the development of novel inhibitors of this receptor. Three reversibly-binding P2Y12 inhibitors are in phase 3 development, ticagrelor, cangrelor and elinogrel. The pharmacology and clinical trial data for each of these inhibitors are discussed and compared with relevant data for the thienopyridines clopidogrel and prasugrel.
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