Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis

Ophira Salomon; David M. Steinberg; Michal Zucker; David Varon; Ariella Zivelin; Uri Seligsohn

doi:10.1160/TH10-05-0307

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2011; 105(02): 269-273
DOI: 10.1160/TH10-05-0307

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis

Ophira Salomon

¹The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel

,

David M. Steinberg

²Department of Statistics and Operations Research, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Israel

,

Michal Zucker

¹The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel

,

David Varon

³Coagulation Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

,

Ariella Zivelin

¹The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel

,

Uri Seligsohn

¹The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel

› Author Affiliations

Abstract

Summary

Factor XI (FXI) plays a dual role in haemostasis and thrombosis. It contributes to thrombin generation and promotes inhibition of fibrinolysis. Severe FXI deficiency was shown to confer protection against arterial and venous thrombosis in animal models without compromising haemostasis. We have previously shown that patients with severe FXI deficiency have a low incidence of ischaemic stroke, but display the usual incidence of myocardial infarction. In the present study, we compared the incidence of deep-vein thrombosis (DVT) in 219 unrelated patients with severe FXI deficiency aged 20–94 to the incidence in a large population-based study. No cases of DVT were observed in the FXI-deficient cohort, a result that is significantly lower than the expected number (4.68) computed from the population-based study. The low incidence remains statistically significant when compared to three other population-based studies. These data suggest that severe FXI deficiency provides protection against DVT.

Keywords

Factor XI - factor XI deficiency - deep-vein thrombosis

Full Text

References

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