Tissue factor, protease activated receptors and pathologic heart remodelling

Silvio Antoniak; Erica Sparkenbaugh; Rafal Pawlinski

doi:10.1160/th14-03-0243

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2014; 112(05): 893-900
DOI: 10.1160/th14-03-0243

Theme Issue Article

Schattauer GmbH

Tissue factor, protease activated receptors and pathologic heart remodelling

Silvio Antoniak

¹Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

,

Erica Sparkenbaugh

¹Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

,

Rafal Pawlinski

¹Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

› Institutsangaben

Abstract

Summary

Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.

Volltext

Referenzen

References
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