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Thromb Haemost 2014; 112(05): 893-900
DOI: 10.1160/th14-03-0243
Theme Issue Article
Schattauer GmbH

Tissue factor, protease activated receptors and pathologic heart remodelling

Silvio Antoniak
1   Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
,
Erica Sparkenbaugh
1   Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
,
Rafal Pawlinski
1   Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
› Author Affiliations Financial support: This work was supported by grants from the Myocarditis Foundation (S. A.) and the National Institutes of Health E. M.S (HL121990–01) and R. P. (HL096679).
Further Information

Publication History

Received: 17 March 2014

Accepted after minor revision: 30 May 2014

Publication Date:
20 November 2017 (online)

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Summary

Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.

 

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