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Thromb Haemost 2015; 114(03): 449-458
DOI: 10.1160/TH14-12-1067
Theme Issue Article
Schattauer GmbH

The role of platelets in inflammation

Mark R. Thomas
1   Department of Cardiovascular Science, University of Sheffield, Sheffield, UK
,
Robert F. Storey
1   Department of Cardiovascular Science, University of Sheffield, Sheffield, UK
› Author Affiliations
Further Information

Publication History

Received: 21 December 2014

Accepted after major revision: 07 August 2015

Publication Date:
21 November 2017 (online)

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Summary

There is growing recognition of the critical role of platelets in inflammation and immune responses. Recent studies have indicated that antiplatelet medications may reduce mortality from infections and sepsis, which suggests possible clinical relevance of modifying platelet responses to inflammation. Platelets release numerous inflammatory mediators that have no known role in haemostasis. Many of these mediators modify leukocyte and endothelial responses to a range of different inflammatory stimuli. Additionally, platelets form aggregates with leukocytes and form bridges between leukocytes and endothelium, largely mediated by platelet P-selectin. Through their interactions with monocytes, neutrophils, lymphocytes and the endothelium, platelets are therefore important coordinators of inflammation and both innate and adaptive immune responses.

Keywords

Platelets - inflammation - infection - immune response - thrombosis
 

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