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DOI: 10.1186/1749-7221-4-19
Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review[*]
Subject Editor:
Publication History
25 April 2009
25 October 2009
Publication Date:
18 September 2014 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00027212/200901/lookinside/thumbnails/10.1186-1749-7221-4-19-1.jpg)
Abstract
Purpose The aim of this study was to compare functional data of different nerve-gap bridging materials evaluated in rat experiments by means of a systematic review.
Materials and methods A systematic review was conducted, searching MEDLINE, HTS and CENTRAL to identify all trials evaluating functional recovery of artificial nerve conduits in the rat model.
Results There was a trend towards a favourable outcome of conduits coated with Schwann-cells compared to the plain synthetics. Histomorphometry, electrophysiology and muscle-weight correlated poorly with functional outcome.
Conclusion Schwann-cell coated conduits showed promising results concerning functional recovery. Further standardization in outcome reporting is encouraged.
*This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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- studies utilizing artificial nerve grafts in the rat. overview of the various studies utilizing artificial nerve grafts in the rat and evaluating functional outcome.
- studies utilizing artificial nerve grafts in the rat. overview of the various studies utilizing artificial nerve grafts in the rat and evaluating functional outcome.