Subscribe to RSS
![](/products/assets/desktop/img/oa-logo.png)
DOI: 10.1186/1749-7221-5-15
Possible role of alpha-lipoic acid in the treatment of peripheral nerve injuries[*]
Subject Editor:
Publication History
10 March 2010
31 August 2010
Publication Date:
19 September 2014 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00027212/201001/lookinside/thumbnails/10.1186-1749-7221-5-15-1.jpg)
Abstract
Recent findings on the antioxidant effects of pretreatment with α-lipoic acid (α-LA) on the crush injury of rat sciatic nerve confirm the possible usefulness of α-LA administration in humans with peripheral nerve injuries. We discussed this issue in relation with our recent results in which the combined employment of α-LA and γ-linolenic acid with a rehabilitation program for six weeks reduced sensory symptoms and neuropathic pain in patients with compressive radiculopathy syndrome from disc-nerve root conflict in comparison with patients submitted to rehabilitation program alone for six weeks.
*This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
-
References
- 1 Senoglu M, Nacitarhan V, Kurutas EB, Senoglu N, Altun I, Atli Y, Ozbag D. Intraperitoneal Alpha-Lipoic Acid to prevent neural damage after crush injury to the rat sciatic nerve. J Brachial Plex Peripher Nerve Inj 2009; 4: 22 10.1186/1749-7221-4-22 2789059 19939272
- 2 Patrick LE, Altmaier EM, Found EM. Long-term outcomes in multidisciplinary treatment of chronic low back pain: results of a 13-year follow-up. Spine 2004; 29: 850-5 10.1097/00007632-200404150-00006 15082983
- 3 Govind J. Lumbar radicular pain. Aust Fam Physician 2004; 33: 409-12 15253601
- 4 Peul WC, van Houwelingen HC, van den Hout WB, Brand R, Eekhof JA, Tans JT, Thomeer RT, Koes BW. Leiden-The Hague Spine Intervention Prognostic Study Group. Surgery versus prolonged conservative treatment for sciatica. N Engl J Med 2007; 356: 2245-56 10.1056/NEJMoa064039 17538084
- 5 Ziegler D, Ametov A, Barinov A, Dyck PJ, Gurieva I, Low PA, Munzel U, Yakhno N, Raz I, Novosadova M, Maus J, Samigullin R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care 2006; 29: 2365-70 10.2337/dc06-1216 17065669
- 6 Ranieri M, Sciuscio M, Cortese AM, Santamato A, Di Teo L, Ianieri G, Bellomo RG, Stasi M, Megna M. The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life. Int J Immunopathol Pharmacol 2009; 22 (3 Suppl) 45-50 19887043
- 7 Milesi MA, Lacan D, Brosse H, Desor D, Notin C. Effect of an oral supplementation with a proprietary melon juice concentrate (Extramel) on stress and fatigue in healthy people: a pilot, double-blind, placebo-controlled clinical trial. Nutr J 2009; 8: 40 10.1186/1475-2891-8-40 2757026 19754931
- 8 Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med 1997; 22: 359-378 10.1016/S0891-5849(96)00269-9 8958163