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CC BY 4.0 · Aorta (Stamford) 2013; 01(05): 244-254
DOI: 10.12945/j.aorta.2013.13-052
State-of-the-Art Review
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Lessons from Animal Models of Arterial Aneurysm

S. David Gertz
1   Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel
,
Yoav Mintz
1   Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel
,
Ronen Beeri
1   Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel
,
Chen Rubinstein
1   Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel
,
Dan Gilon
1   Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel
,
Leah Gavish
1   Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel
,
Yacov Berlatzky
1   Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel
,
Liat Appelbaum
1   Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel
,
Lilach Gavish
1   Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel
› Author Affiliations
Further Information

Publication History

17 October 2013

30 October 2013

Publication Date:
28 September 2018 (online)

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Abstract

We review the results from the most common animal models of arterial aneurysm, including recent findings from our novel, laparoscopy-based pig model of abdominal aortic aneurysm, that contribute important insights into early pathogenesis. We emphasize the relevance of these findings for evaluation of treatment protocols and novel device prototypes for mechanism-based prevention of progression and rupture.

Key Words

Abdominal aortic aneurysm - Arterial aneurysm - Animal models - Periarterial calcium chloride
 

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