Lessons from Animal Models of Arterial Aneurysm

S. David Gertz; Yoav Mintz; Ronen Beeri; Chen Rubinstein; Dan Gilon; Leah Gavish; Yacov Berlatzky; Liat Appelbaum; Lilach Gavish

doi:10.12945/j.aorta.2013.13-052

AORTA, Table of Contents

CC BY 4.0 · Aorta (Stamford) 2013; 01(05): 244-254
DOI: 10.12945/j.aorta.2013.13-052

State-of-the-Art Review

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Lessons from Animal Models of Arterial Aneurysm

S. David Gertz

¹Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel

,

Yoav Mintz

¹Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel

,

Ronen Beeri

¹Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel

,

Chen Rubinstein

¹Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel

,

Dan Gilon

¹Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel

,

Leah Gavish

¹Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel

,

Yacov Berlatzky

¹Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel

,

Liat Appelbaum

¹Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel

,

Lilach Gavish

¹Institute for Medical Research (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel

› Author Affiliations

Abstract

We review the results from the most common animal models of arterial aneurysm, including recent findings from our novel, laparoscopy-based pig model of abdominal aortic aneurysm, that contribute important insights into early pathogenesis. We emphasize the relevance of these findings for evaluation of treatment protocols and novel device prototypes for mechanism-based prevention of progression and rupture.

Key Words

Abdominal aortic aneurysm - Arterial aneurysm - Animal models - Periarterial calcium chloride

Full Text

References

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