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CC BY 4.0 · Aorta (Stamford) 2016; 04(06): 219-225
DOI: 10.12945/j.aorta.2016.16.025
Original Research Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Asymmetric Dimethylarginine in Patients with Ascending Aortic Aneurysms

Natalia D. Gavriliuk
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
,
Tatiana A. Druzhkova
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
,
Olga B. Irtyuga
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
,
Alexandr A. Zhloba
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
2   Department of Biochemistry, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia
,
Tatiana F. Subbotina
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
2   Department of Biochemistry, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia
,
Vladimir E. Uspenskiy
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
,
Nina P. Alexeyeva
3   Department of Medical Statistics, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia
,
Olga M. Moiseeva
1   Department of Heart and Vessels Research, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russia
› Author Affiliations
Further Information

Publication History

13 May 2016

24 October 2016

Publication Date:
24 September 2018 (online)

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Abstract

Background: Ascending thoracic aortic aneurysm (aTAA) is a heterogeneous group of disorders that involve impaired endothelial function. The nitric oxide (NO) synthase inhibitor asymmetric dimethylarginine (ADMA) serves as an endothelial dysfunction marker. Thus, we investigated ADMA levels in patients with aTAA.

Methods: Eighty-six patients with aTAA and 18 healthy individuals were enrolled. All patients underwent echocardiography. Plasma ADMA levels were measured using high-performance liquid chromatography.

Results: ADMA levels were higher in aTAA patients than in control patients (p = 0.034). According to the multivariable regression model, higher ADMA levels were associated with ascending aortic diameter (p = 0.017), smoking (p = 0.016), and log-transformed estimated glomerular filtration rate (eGFR, p = 0.005).

Conclusion: This pilot study demonstrates an association of ADMA with ascending aortic dilatation; however, further studies are needed to investigate whether increased ADMA levels underlie aTAA development.

Key Words

Asymmetric dimethylarginine - Thoracic aortic aneurysm - Endothelial dysfunction
 

  • References

  • 1 Elefteriades JA, Rizzo JA. Epidemiology: incidence, prevalence, and trends. In: Elefteriades JA. , editor. Acute Aortic Disease. New York: Informa Healthcare; 2007. p. 89-98
    Search in Google Scholar
  • 2 Landenhed M, Engström G, Gottsäter A, Caulfield M, Hedblad B, Newton-Cheh C. , et al. Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: A prospective cohort study. J Am Heart Assoc 2015; 21: e001513 . DOI: 10.1161/JAHA.114.001513
    PubMedSearch in Google Scholar
  • 3 Pokrovsky AV. Incidence and prevalence of aortic diseases. In: Pokrovsky AV. , editors. Diseases of Aorta and Its Branches. 1st ed. Moscow: Medicine; 1979. p. 326-327
    Search in Google Scholar
  • 4 Hagan PG, Nienaber CA, Isselbacher EM, Bruckman D, Kravite DJ, Russman PL. , et al. The International Registry of Acute Aortic Dissection (IRAD) new insights into an old disease. JAMA 2000; 283: 897-903 . DOI: 10.1001/jama.283.7.897
    CrossrefPubMedSearch in Google Scholar
  • 5 Varrica A, Satriano A, de Vincentiis C, Biondi A, Trimarchi S, Ranucci M. , et al. Bentall operation in 375 patients: long-term results and predictors of death. J Heart Valve Dis 2014; 23: 127-134 . PMID: 24779339
    PubMedSearch in Google Scholar
  • 6 Williams JB, Peterson ED, Zhao Y, O’Brien SM, Andersen ND, Miller DC. , et al. Contemporary results for proximal aortic replacement in North America. J Am Coll Cardiol 2012; 60: 1156-1162 . DOI: 10.1016/j.jacc.2012.06.023
    CrossrefPubMedSearch in Google Scholar
  • 7 Van Bogerijen GH, Tolenaar JL, Grassi V, Lomazzai C, Segreti S, Rampoldi V. , et al. Biomarkers in TAA-the Holy Grail. Prog Cardiovasc Dis 2013; 56: 109-115 . DOI: 10.1016/j.pcad.2013.05.004
    CrossrefPubMedSearch in Google Scholar
  • 8 Ikonomidis JS, Ivey CR, Wheeler JB, Akerman AW, Rice A, Patel RK. , et al. Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease. J Thorac Cardiovasc Surg 2013; 145: 1326-1333 . DOI: 10.1016/j.jtcvs.2012.12.027
    CrossrefPubMedSearch in Google Scholar
  • 9 Ari H, Ari S, Erdoğan E, Tiryakioğlu O, Üstündağ Y, Huysal K. , et al. A novel predictor of restenosis and adverse cardiac events: asymmetric dimethylarginine. Heart Vessels 2010; 25: 19-26 . DOI: 10.1007/s00380-009-1158-x
    CrossrefPubMedSearch in Google Scholar
  • 10 Miyazaki H, Matsuoka H, Cooke JP, Usui M, Ueda S, Okuda S. , et al. Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis. Circulation 1999; 99: 1141-1146 . DOI: 10.1161/01.CIR.99.9.1141
    CrossrefPubMedSearch in Google Scholar
  • 11 Zhloba A, Subbotina TF. Homocysteinylation score of high-molecular weight plasma proteins. Amino Acids 2014; 46: 893-899 . DOI: 10.1007/s00726-013-1652-4
    CrossrefPubMedSearch in Google Scholar
  • 12 Tzemos N, Lyseggen E, Silversides C, Jamorski M, Tong JH, Harvey P. , et al. Endothelial function, carotid–femoral stiffness, and plasma matrix metalloproteinase-2 in men with bicuspid aortic valve and dilated aorta. J Am Coll Cardiol 2010; 55: 660-668 . DOI: 10.1016/j.jacc.2009.08.080
    CrossrefPubMedSearch in Google Scholar
  • 13 Warner PJ, Al-Quthami A, Brooks EL, Kelley-Hedqepeth A, Patvardan E, Kuvin JT. , et al. Augmentation index and aortic stiffness in bicuspid aortic valve patients with non-dilated proximal aortas. BMC Cardiovasc Disord 2013; 13: 19 . DOI: 10.1186/1471-2261-13-19
    CrossrefPubMedSearch in Google Scholar
  • 14 Rudic RD, Shesely EG, Maeda N. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest 1998; 101: 731-736 . DOI: 10.1172/JCI1699
    CrossrefPubMedSearch in Google Scholar
  • 15 Nathan C, Xie QW. Nitric oxide synthases: roles, tolls, and controls. Cell 1994; 78: 915-918 . DOI: 10.1016/0092-8674(94)90266-6
    CrossrefPubMedSearch in Google Scholar
  • 16 Lee TC, Zhao YD, Courtman DW, Stewart DJ. Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase. Circulation 2000; 101: 2345-2348 . DOI: 10.1161/01.CIR.101.20.2345
    CrossrefPubMedSearch in Google Scholar
  • 17 Aicher D, Urbich C, Zeiher A, Dimmeler S, Schäfers HJ. Endothelial nitric oxide synthase in bicuspid aortic valve disease. Ann Thorac Surg 2007; 83: 1290-1294 . DOI: 10.1016/j.athoracsur.2006.11.086
    CrossrefPubMedSearch in Google Scholar
  • 18 Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 2007; 115: 459-467 . DOI: 10.1161/CIRCULATIONAHA.106.628875
    CrossrefPubMedSearch in Google Scholar
  • 19 Toker A, Yerlikaya F, Yener Y, Toy H. Serum homocysteine, arginine, citrulline and asymmetric dimethyl arginine levels, and histopathologic examination of the abdominal aorta in rats exposed to acrylamide. Biotech Histochem 2013; 88: 103-108 . DOI: 10.3109/10520295.2012.745950
    CrossrefPubMedSearch in Google Scholar
  • 20 Ali OA, Chapman M, Nguyen TH, Chirkov YY, Heresztyn T, Mundisuqih J. , et al. Interactions between inflammatory activation and endothelial dysfunction selectively modulate valve disease progression in patients with bicuspid aortic valve. Heart 2014; 100: 800-805 . DOI: 10.1136/heartjnl-2014-305509
    CrossrefPubMedSearch in Google Scholar
  • 21 Drapisz S, Góralczyk T, Jamka-Miszalski T, Olszowska M, Undas A. Nonstenotic bicuspid aortic valve is associated with elevated plasma asymmetric dimethylarginine. J Cardiovasc Med (Hagerstown) 2013; 14: 446-452 . DOI: 10.2459/JCM.0b013e3283588dfa
    CrossrefPubMedSearch in Google Scholar
  • 22 Campesi I, Carru C, Zinellu A, Occhioni S, Sanna M, Palermo M. , et al. Regular cigarette smoking influences the transsulfuration pathway, endothelial function, and inflammation biomarkers in a sex-gender specific manner in healthy young humans. Am J Transl Res 2013; 5: 497-509 . PMID: 23977409
    PubMedSearch in Google Scholar
  • 23 Alkan FA, Cakmak G, Karis D, Saqlam ZA, Saler T. The evaluation of plasma viscosity and endothelial dysfunction in smoking individuals. Clin Hemorheol Microcirc 2014; 58: 403-413 . DOI: 10.3233/CH-131796
    PubMedSearch in Google Scholar
  • 24 Hiratzka LF, Bakris GL, Beckman JA, Bersin RM, Carr VF, Casey Jr DE. , et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the diagnosis and management of patients with thoracic aortic disease. J Am Coll Cardiol 2010; 55: e27-e129 . DOI: 10.1016/j.jacc.2010.02.015
    CrossrefPubMedSearch in Google Scholar
  • 25 Dapunt OE, Galla JD, Sadeghi AM, Lansman SL, Mezrow CK, de Asla RA. , et al. The natural history of thoracic aortic aneurysms. J Thorac Cardiovasc Surg 1994; 107: 1323-1332 . PMID: 8176976
    PubMedSearch in Google Scholar