Summary
Objective: Interstitial nephritis as a form of renal diseases can be found frequently among pigs. Nevertheless, prevalence and aetiology need to be investigated in more detail as reports about detailed analysis are lacking. Material and methods: In the present study, a total of 169 kidneys of conventionally and organically raised pigs were randomly chosen at slaughter and classified according to the degree of inflammation and the participating inflammatory cells. Moreover, PCV2 as an infectious agent was analysed by immunohistochemistry and in-situ hybridisation. Results: All of the investigated kidneys displayed mild interstitial lesions. Inflammatory cells included lymphocytes, macrophages, plasma cells, eosinophilic and neutrophilic granulocytes. Significant (p ≤ 0.0001) differences concerning the grade of inflammation and inflammatory cell occurrence could be observed between kidneys of conventionally and organically raised pigs. In comparison to conventionally raised pigs organically raised pigs showed significant (p ≤ 0.0001) more frequently a mild form of nephritis as well as a significant (p ≤ 0.0001) more frequent occurrence of lympho cytes and macrophages. In contrast to that, conventionally raised pigs had a significant (p ≤ 0.0001) higher occurrence rate of a mild to moderate form of nephritis as well as a significant (p ≤ 0.0001) higher level in occurrence of lymphocytes, macrophages, plasma cells, and neutrophilic granulocytes when compared to organically raised pigs. PCV2 DNA was detected in the kidney of only one animal. Conclusion: Interstitial nephritis was found in conventionally and organically raised pigs and PCV2 was ruled out as a major pathogen for interstitial nephritis in slaughter pigs. Clinical relevance: Because of the high prevalence and unknown cause further investigations are necessary to delineate the clinic relevance of this alteration and its pathogenesis.
Keywords
Renal diseases - porcine circovirus type 2 - organic husbandry system - conventional husbandry system
