Vakuumassistierte Wundbehandlung (Negative Pressure Wound Therapy, NPWT) in der Kleintiermedizin

M. C. Nolff; A. Meyer-Lindenberg

doi:10.15654/TPK-150957

Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere, Table of Contents

Tierarztl Prax Ausg K Kleintiere Heimtiere 2016; 44(01): 26-37
DOI: 10.15654/TPK-150957

Übersichtsartikel

Schattauer GmbH

Vakuumassistierte Wundbehandlung (Negative Pressure Wound Therapy, NPWT) in der Kleintiermedizin

Wirkweise, Anwendung und Indikationen Article in several languages: deutsch | English

M. C. Nolff

¹Chirurgische und Gynäkologische Kleintierklinik, Zentrum für Klinische Tiermedizin, Ludwig-Maximilians-Universität München

,

A. Meyer-Lindenberg

¹Chirurgische und Gynäkologische Kleintierklinik, Zentrum für Klinische Tiermedizin, Ludwig-Maximilians-Universität München

› Author Affiliations

Abstract

Zusammenfassung

Die Behandlung offener Wunden gehört zu den alltäglichen Herausforderungen in der Tiermedizin. In den letzten Jahren hat sich mit der vakuumassistierten Wundbehandlung (Negative Pressure Wound Therapy, NPWT) eine neue Therapieform entwickelt. Durch ihren Einsatz lassen sich die Heilung offener Wunden und die Einheilungsrate freier Hauttransplantate beim Kleintier signifikant verbessern. In diesem Überblick werden Wirkweise, Indikationen sowie Komplikationen der Negative Pressure Wound Therapy dargestellt.

Schlüsselwörter

Offene Wundtherapie - Hauttransplantate - offenes Abdomen - Wundheilungsstörungen

Full Text

References

Literatur
1 Abramo F, Argiolas S, Pisani G, Vannozzi I, Miragliotta V. Effect of a hydrocolloid dressing on first intention healing surgical wounds in the dog: a pilot study. Aust Vet J 2008; 86 (03) 95-99.
2 Argenta LC, Morykwas MJ, Marks MW, DeFranzo AJ, Molnar JA, David LR. Vacuum-assisted closure: state of clinic art. Plast Reconstr Surg 2006; 117: 127-142.
3 Armstrong DG, Lavery LA, Abu-Rumman P, Espensen EH, Vazquez JR, Nixon BP, Boulton AJ. Outcomes of subatmospheric pressure dressing therapy on wounds of the diabetic foot. Ostomy Wound Manage 2002; 48: 64-68.
4 Assadian O, Assadian A, Stadler M. Bacterial growth kinetic without the influence of the immune system using vacuum-assisted closure dressing with and without negative pressure in an in vitro wound model. Int Wound J. 2010 07 283-289
5 Atkins BZ, Wooten MK, Kistler J. Does negative pressure wound therapy have a role in preventing poststernotomy wound complications?. Surg Innov 2009; 16: 140-146.
6 Azzopardi EA, Boyce DE, Dickson WA. Application of topical negative pressure (vacuum-assisted closure) to split thickness skin grafts. Ann Plast Surg 2013; 70: 23-29.
7 Back DA, Scheuermann-Poley C, Willy C. Recommendations on negative pressure wound therapy with instillation and antimicrobial solutions - when, where and how to use: what does the evidence show?. Int Wound J 2013; 10 (01) 32-42.
8 Banwell P, Teot L. Topical negative pressure (TNP): the evolution of a novel wound therapy. J Tissue Viability 2006; 16: 16-24.
9 Becker ST, Rennekampff HO, Alkatout I. Comparison of vacuum and conventional wound dresings for full thickness skin grafts in the minipig model. Int J Oral Maxillofac Surg 2010; 39: 699-704
10 Ben-Amotz R, Lanz OI, Miller JM, Filipowicz DE, King MD. The use of vacuum assisted closure therapy for the treatment of distal extremity wounds in 15 dogs. Vet Surg 2007; 36: 684-690.
11 Bertran J, Farrell M, Fitzpatrick N. Successful wound healing over exposed metal implants using vacuum-assisted wound closure in a dog. JSAP 2013; 54 (07) 381-538.
12 Blume PA, Key JJ, Thakor P, Thakor S, Sumpio B. Retrospective evaluation of clinical outcomes in subjects with split thickness skin graft: comparing VAC therapy and conventional therapy in foot and ankle reconstructive surgeries. Int Wound J 2010; 7: 480-487.
13 Bristow PC, Perry KL, Halfacree ZJ, Lipscomb VJ. Use of vacuum-assisted closure to maintain viability of a skin flap in a dog. J Am Vet Med Assoc 2013; 243 (06) 863-868.
14 Buote NJ, Havig ME. The use of vacuum-assisted closure in the management of septic peritonitis in six dogs. J Am Anim Hosp Assoc 2012; 48: 164-171.
15 Cioffi KM, Schmiedt CW, Cornell KK, Radlinsky MG. Retrospective evaluation of vacuum-assisted peritoneal drainage for the treatment of septic peritonitis in dogs and cats: 8 cases (2003-2010). J Vet Emerg Crit Care 2012; 22 (05) 601-609.
16 Colli A. First experience with a new negative pressure incision management system on surgical incisions after cardiac surgery in high risk patients. J Cardiothor Surg 2011; 6: 160-165.
17 Colwell AS, Donaldson MC, Belkin M, Orgill DP. Management of early groin vascular bypass graft infections with sartorius and rectus femoris flaps. Ann Plast Surg 2004; 52: 49-53.
18 Corr S. Intensive, Extensive, Expensive: Management of distal limb shearing injuries in cats. JFMS 2009; 11: 747-757.
19 Coutin JV, Lanz OI, Magnin-Bissel GC, Miller EI, Werre SR, Riegel TO. Cefazolin concentration in surgically created wounds treated with negative pressure wound therapy compared to surgically created wounds treated with nonadherent wound dressings. Vet Surg 2015; 44 (01) 9-16.
20 Demaria R, Giovannini UM, Teot L, Chaptal PA. Using VAC to treat a vascular bypass site infection. J Wound Care 2010; 10: 12-13.
21 Demaria M, Stanley BJ, Hauptman JG, Steficek BA, Fritz MC, Ryan JM, Lam NA, Moore TW, Hadley HS. Effects of negative pressure wound therapy on healing of open wounds in dogs. Vet Surg 2011; 40: 658-669.
22 Egemen O, Ozkaya O, Ozturk MB, Aksan T, Orman Ç, Akan M. Effective use of negative pressure wound therapy provides quick wound-bed preparation and complete graft take in the management of chronic venous ulcers. Int Wound J 2012; 9 (02) 199-205.
23 Fahie MA, Shettko D. Evidence-based wound management: a systematic review of therapeutic agents to enhance granulation and epithelialization. Vet Clin North Am Small Anim Pract 2007; 37 (03) 559-577.
24 Fraccalvieri M, Zingarelli E, Ruka E, Antoniotti U, Coda R, Sarno A, Bocchiotti MA, Bruschi S. Negative pressure wound therapy using gauze and foam: histological, immunohistochemical and ultrasonography morphological analysis of the granulation tissue and scar tissue. Int Wound J 2011; 8: 355-364.
25 Franklin ME, Alvarez A, Russek K. Negative pressure therapy: a viable option for general surgical management of the open abdomen. Surg Innov 2012; 19 (04) 353-363.
26 Garcia-Cardena G, Comander J, Anderson KR, Blackman BR, Gimbrone Jr. MA. Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc Natl Acad Sci USA 2006; 98: 4478-4485.
27 Gemeinhardt KD. Vacuum assisted closure for management of a traumatic neck wound in a horse. Equine Vet Educ 2004; 17: 27-33.
28 Genecov DG, Schneider AM, Morykwas MJ, Parker D, White WL, Argenta LC. A controlled subatmospheric pressure dressing increases the rate of skin graft donor site re-epithelialization. Ann Plast Surg 1998; 40: 219-225.
29 Greene AK, Puder M, Roy R, Arsenault D, Kwei S, Moses MA, Orgill DP. Microdeformational wound therapy: effects on angiogenesis and matrix metalloproteinases in chronic wounds of 3 debilitated patients. Ann Plast Surg 2006; 56: 418-422.
30 Guille AE, Tseng LW, Orsher RJ. Use of vacuum-assisted closure for management of a large skin wound in a cat. JAVMA 2007; 230: 1669-1673.
31 Hadley HS, Stanley BJ, Fritz MC, Hauptman JG, Steficek BA. Effects of a cross-linked hyaluronic acid based gel on the healing of open wounds in dogs. Vet Surg 2013; 42 (02) 161-169.
32 Heller G, Savolainen H, Widmer MK, Makaloski V, Menth M, Schmidli J. [Vacuum assisted closure in vascular surgery]. Zentralbl Chir 2004; 129 (Suppl. 01) 66-70
33 Heller L, Levin SL, Butler CE. Management of abdominal wound dehiscence using vacuum assisted closure in patients with compromised healing. Am J Surg 2006; 191: 165-172.
34 Howe LM. Current concepts in negative pressure wound therapy. Vet Clin North Am Small Anim Pract 2015; 45 (03) 565-584.
35 Huang S, Ingber DE. Shape-dependent control of cell growth, differentiation, and apoptosis: switching between attractors in cell regulatory networks. Exp Cell Res 2000; 261: 91-103.
36 Ichioka S, Watanabe H, Sekiya N, Shibata M, Nakatsuka T. A technique to visualize wound bed microcirculation and the acute effect of negative pressure. Wound Repair Regen 2008; 16: 460-465.
37 Isago T, Nozaki M, Kikuchi Y, Honda T, Nakazawa H. Effects of different negative pressures on reduction of wounds in negative pressure dressings. J Dermatol 2003; 30: 596-601.
38 Jacobs S, Simhaee DA, Marsano A, Fomovsky GM, Niedt G, Wu JK. Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: a rodent model. J Plast Reconstr Aesthet Surg 2009; 62: 1331-1338.
39 Jones SM, Banwell PE, Shakespeare PG. Advances in wound healing: Topical negative pressure therapy. Postgrad Med J 2005; 81: 353-357.
40 Jones GA, Butler J, Lieberman I, Schlenk R. Negative-pressure wound therapy in the treatment of complex postoperative spinal wound infections: complications and lessons learned using vacuum-assisted closure. J Neurosurg Spine 2007; 6: 407-411.
41 Kamolz LP, Andel H, Haslik W, Winter W, Meissl G, Frey M. Use of subatmospheric pressure therapy to prevent burn wound progression in human: first experiences. Burns 2004; 30: 253-258.
42 Kilpadi DV, Bower CE, Reade CC, Robinson PJ, Sun YS, Zeri R, Nifong LW, Wooden WA. Effect of Vacuum Assisted Closure Therapy on early systemic cytokine levels in a swine model. Wound Repair Regen 2006; 14: 210-215.
43 Kilpadi DV, Cunningham MR. Evaluation of closed incision management with negative pressure wound therapy (CIM): hematoma/seroma and involvement of the lymphatic system. Wound Repair Regen 2011; 19: 588-596.
44 Kim EK, Hong JP. Efficacy of negative pressure therapy to enhance take of 1-stage allodermis and a split-thickness graft. Ann Plast Surg 2007; 58 (05) 536-540.
45 Lafortune M, Flemming GJ, Wheeler JL, Göbel T, Mozingo DW. Wound management in a juvenile tiger (Panthera tigris) with vacuum assisted closure (V.A.C. Therapy). J Zoo Wildl Med 2007; 38: 341-344.
46 Lalliss SJ, Stinner DJ, Waterman SM, Branstetter JG, Masini BD, Wenke JC. Negative pressure wound therapy reduces pseudomonas wound contamination more than Staphylococcus aureus. J Orthop Trauma 2010; 24: 598-602.
47 Lee SY, Nikura T, Miwa M, Sakai Y, Oe K, Fukazawa T, Kawakami Y, Kurosaka M. Negative pressure wound therapy for the treatment of infected wounds with exposed knee joint after patellar fracture. Orthopedics 2011; 34: 211-216.
48 Llanos S, Danilla S, Barraza C, Armijo E, Piñeros JL, Quintas M, Searle S, Calderon W. Effectiveness of negative pressure closure in the integration of split thickness skin grafts. A randomized, double masked, contolled trial. Ann Surg 2006; 244: 700-705.
49 Meeker J, Weinhold P, Dahners L. Negative pressure therapy on primarily closed wounds improves wound healing parameters at 3 days in a porcine model. J Orthop Trauma 2011; 25: 756-761.
50 Mooney JF, Argenta LC, Marks MW, Morykwas MJ, DeFranzo AJ. Treatment of soft tissue defects in pediatric patients using the V.A.C. system. Clin Orthop Rel Res 2000; 376: 26-31.
51 Morgan PW, Binnington AG, Miller CW, Smith DA, Valliant A, Prescott JF. The effect of occlusive and semiocclusive dressings on the healing of acute full thickness skin wounds on the forelimbs of dogs. Vet Surg 1994; 23 (06) 494-502.
52 Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg 1997; 38: 553-562.
53 Morykwas MJ, Faler BJ, Pearce DJ, Argenta LC. Effects of varying levels of subatmospheric pressure on the rate of granulation tissue formation in experimental wounds in swine. Ann Plast Surg 2001; 47: 547-551.
54 Moues CM, Vos MC, van den Bemd GJ, Stijnen T, Hovius SE. Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial. Wound Repair Regen 2004; 12: 11-17.
55 Mullally C, Carey K, Seshadri R. Use of a nanocristalline silver dressing and vacuum-assisted closure in a severely burned dog. J Vet Emerg Crit Care 2010; 20 (05) 456-463.
56 Nolff M, Meyer-Lindenberg A. Necrotising fasciitis in a domestic shorthair cat - negative pressure wound therapy assisted debridement and reconstruction. J Small Anim Pract 2014; 56 (04) 281-284.
57 Nolff MC, Fehr M, Bolling A, Dening R, Kramer S, Reese S, Meyer-Lindenberg A. Comparison of Negative Pressure Wound Therapy, silver coated foam dressing and conventional bandages in open wound treatment in the dog. A retrospective study of 50 cases. Vet Comp Orthop Traumatol 2015; 28 (01) 30-36.
58 Nolff MC, Meyer-Lindenberg A. Negative pressure wound therapy augmented full thickness free skin grafting in the cat: outcome in 10 grafts transferred to six cats. J Feline Med Surg 2015; 17 (12) 1041-1048.
59 Nolff MC, Layer A, Meyer-Lindenberg A. Negative pressure wound therapy with instillation for augmented body wall reconstruction using an artificial mesh in a dachshund. Aust Vet J 2015; 93 (10) 367-372.
60 Nolff MC, Flatz KM, Meyer-Lindenberg A. Preventive incisional negative pressure wound therapy (Prevena^®) for an at-risk-surgical closure in a female Rottweiler. Schweiz Arch Tierheilk 2015; 157: 105-109.
61 Or M, Van Goethem B, Polis I, Spillebeen A, Vandekerckhove P, Saunders J, de Rooster H. Pedicle digital pad transfer and negative pressure wound therapy for reconstruction of the weight-bearing surface after complete digital loss in a dog. Vet Comp Orthop Traumatol 2015; 28 (02) 140-144.
62 Orgill DP, Manders EK, Sumpio BE, Lee RC, Attinger CE, Gurtner GC, Ehrlich HP. The mechanisms of action of vacuum assisted closure: more to learn. Surgery 2009; 146: 40-51.
63 Owen L, Hotston-Moore A, Holt P. Vacuum-assisted wound closure following urine induced skin and thight muscle necrosis in a cat. Vet Comp Orthop Traumatol 2009; 5: 417-421.
64 Pachowsky M, Gusinde J, Klein A, Lehrl S, Schulz-Drost S, Schlechtweg P, Pauser J, Gelse K, Brem MH. Negative pressure wound therapy to prevent seromas and treat surgical incisions after total hip arthroplasty. Int Orthop 2012; 36: 719-722.
65 Pitt KA, Stanley BJ. Negative pressure wound therapy: experience in 45 dogs. Vet Surg 2014; 43 (04) 380-387.
66 Perry KL, Rutherford L, Sajik Bruce M. A preliminary study of the effect of closed incision management with negative pressure wound therapy over high risk incisions. BMC Vet Res 2015; 11: 279.
67 Petzina R, Hoffmann J, Navasardyan A, Malmsjö M, Stamm C, Unbehaun A, Hetzer R. Negative pressure wound therapy for post-sternotomy mediastinitis reduces mortality rate and sternal reinfection rate compared to conventional treatment. Eur J Cardiothorac Surg 2012; 38: 110-113.
68 Ramsey DT, Pope ER, Wagner-Mann C, Berg JN, Swaim SF. Effects of three occlusive dressing materials on healing of full-thickness skin wounds in dogs. Am J Vet Res 1995; 56 (07) 941-949.
69 Reddix Jr RN, Tyler HK, Kulp B, Webb LX. Incisional vacuum assisted wound closure in morbidly obese patients undergoing acetabular fracture surgery. Am J Orthop 2009; 38: 32-35.
70 Rozhdestvin VA, Nurgaliev TN, Kiverov SV. Vacuum-aspiration in the treatment of stab wounds of soft tissues. Ortop Traumatol Protez 1987; 7: 32.
71 Saaiq M, Hameed UD, Khan MI, Chaudhery SM. Vacuum assisted closure therapy as a pretreatment for split thickness skin grafts. J Coll Physicians Surg Pak 2010; 20 (10) 675-679.
72 Saxena V, Hwang CW, Huang S, Eichbaum Q, Ingber D, Orgill DP. Vacuum assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg 2004; 114: 1086-1096.
73 Scherer SS, Pietramaggiori G, Mathews JC, Prsa MJ, Huang S, Orgill DP. The mechanism of action of the vacuum-assisted closure device. Plast Reconstr Surg 2008; 122: 786-797.
74 Schlatterer D, Webb LX. Orthopedic indications for negative pressure wound therapy. Ostomy Wound Manage 2005; 51: 27-28.
75 Sjogren J, Gustafsson R, Wackenfors A, Malmsjö M, Algotsson L, Ingemansson R. Effects of vacuum-assisted closure on central hemodynamics in a sternotomy wound model. Interact Cardiovasc Thorac Surg 2004; 3: 666-671.
76 Stanley BJ, Pitt KA, Weder CD, Fritz MC, Hauptman JG, Steficek BA. Effects of negative pressure wound therapy on healing of free thickness skin grafts in dogs. Vet Surg 2013; 42 (05) 511-522.
77 Stannard JP, Volgas DA, Stewart R, McGwin Jr G, Alonso JE. Negative pressure wound therapy after severe open fractures: a prospective randomized study. J Orthop Trauma 2009; 23: 552-557.
78 Stannard JP, Volgas DA, Mc Gwin G, Stewart RL, Obremskey W, Moore T, Anglen JO. Incisional Negative Pressure Wound Therapy after high-risk lower extremity fractures. J Orthop Trauma 2012; 26: 37-42.
79 Swaim SF, Gillette RL, Sartin EA, Hinkle SH, Coolman SL. Effects of a hydrolyzed collagen dressing on the healing of open wounds in dogs. Am J Vet Res 2000; 61 (12) 1574-1578.
80 Swanson ES, Freeman LI, Seleem MN, Snyder PW. Biofilm-infected wounds in a dog. J Am Vet Med Assoc 2014; 244 (06) 600-707.
81 Tambella AM, Attili AR, Dini F, Palumbo Piccionello A, Vullo C, Serri E, Scrollavezza P, Dupré G. Autologous platelet gel to treat chronic decubital ulcers: a randomized, blind controlled clinical trial in dogs. Vet Surg 2014; 43 (06) 726-733.
82 Thompson G. An overview of negative pressure wound therapy (NPWT). Br J Community Nurs 2008; 13: 23-30.
83 Voinchet V, Magalon G. Vacuum assisted closure. Wound healing by negative pressure. Ann Chir Plast Esthet 1996; c41: 583-589
84 Yang CC, Chang DS, Webb LX. Vacuum-assisted closure for fasciotomy wounds following compartment syndrome of the leg. J Surg Orthop Adv 2006; 15: 19-23.
85 Wackenfors A, Gustafsson R, Sjogren J, Algotsson L, Ingemansson R, Malmsjö M. Blood flow responses in the peristernal thoracic wall during vacuum assisted closure therapy. Ann Thorac Surg 2005; 79: 1724-1730 discussion 1730-1721
86 Waltzmann JT, Bell DE. Vacuum assisted closure device as a split thickness skin graft bolster in the burn population. J Burn Care Res 2014; 35 (05) 338-342.
87 Weed T, Ratliff C, Drake DB. Quantifying bacterial bioburden during negative pressure wound therapy: does the wound VAC enhance bacterial clearance?. Ann Plast Surg 2004; 52: 276-279.
88 Wilkes RP, Kilpad DV, Zhao Y, Kazala R, McNulty A. Closed incision management with negative pressure wound therapy (CIM): biomechanics. Surg Innov 2012; 19 (01) 67-75.
89 Winkler JT, Swaim SF, Sartin EA, Henderson RA, Welch JA. The effect of a porcine-derived small intestinal submucosa product on wounds with exposed bone in dogs. Vet Surg 2002; 31 (06) 541-551.