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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2021; 79(04): 354-369
DOI: 10.1590/0004-282X-ANP-2020-0432
BRAZILIAN ACADEMY OF NEUROLOGY

Cannabinoids in Neurology - Position paper from Scientific Departments from Brazilian Academy of Neurology

Canabinoides em Neurologia - Artigo de posicionamento dos Departamentos Científicos da Academia Brasileira de Neurologia
Sonia Maria Dozzi BRUCKI 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
2   Hospital Santa Marcelina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Tarso ADONI 
3   Hospital Sírio-Libanês, Núcleo de Neurociências, São Paulo SP, Brazil;
4   Hospital Heliópolis, Departamento de Neurologia, São Paulo SP, Brazil.
,
Carlos Mauricio Oliveira ALMEIDA 
5   Universidade Estadual do Amazonas, Departamento de Neurologia, Manaus AM, Brazil.
6   Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto SP, Brazil.
,
Daniel Ciampi de ANDRADE 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Renato ANGHINAH 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Luciana Mendonça BARBOSA 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Rodrigo BAZAN 
7   Universidade Estadual Paulista “Júlio de Mesquita Filho”, Faculdade de Ciências Médicas e Biológicas de Botucatu, Hospital das Clínicas, Departamento de Neurologia, Psicologia e Psiquiatria, Botucatu SP, Brazil.
,
Alzira Alves de Siqueira CARVALHO 
8   Faculdade de Medicina do ABC, Departamento de Neurociências, Santo André SP, Brazil.
,
William CARVALHO 
9   Hospital Geral de Goiânia Dr Alberto Rassi, Departamento de Neurologia, Goiânia GO, Brazil.
,
Paulo Pereira CHRISTO 
10   Santa Casa de Belo Horizonte, Departamento de Neurologia, Belo Horizonte MG, Brazil.
11   Universidade Federal de Minas Gerais, Hospital das Clínicas, Departamento de Neurologia, Belo Horizonte MG, Brazil.
,
Marcus Della COLETTA 
12   Universidade do Estado do Amazonas, Escola Superior de Ciências da Saúde, Manaus AM, Brazil.
,
Adriana Bastos CONFORTO 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Ylmar CORREA-NETO 
13   Universidade Federal de Santa Catarina, Santa Catarina RS, Brazil.
,
Eliasz ENGELHARDT 
14   Universidade Federal do Rio de Janeiro, Instituto de Neurologia Deolindo Couto, Departamento de Neurologia, Rio de Janeiro RJ, Brazil.
,
Marcondes Cavalcante FRANÇA  JUNIOR
15   Universidade Estadual de Campinas, Departamento de Neurologia, Campinas SP, Brazil.
,
Clelia FRANCO 
16   Hospital das Clínicas, Recife PE, Brazil.
,
Felipe VON GLEHN 
17   Universidade Estadual de Campinas, Instituto de Biologia, Genética, Imunologia e Bioagentes, Campinas SP, Brazil.
,
Helio Rodrigues GOMES 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Caroline Gomes de Barros HOULY 
18   Faculdade de Medicina do ABC, Departamento de Neurologia, Santo André SP, Brazil.
,
Alexandre Ottoni KAUP 
19   Hospital Israelita Albert Einstein, São Paulo SP, Brazil.
,
Fernando KOWACS 
20   Universidade Federal de Ciências da Saúde de Porto Alegre, Departamento de Clínica Médica, Porto Alegre RS, Brazil.
21   Hospital Moinhos de Vento, Serviço de Neurologia e Neurocirurgia, Porto Alegre RS, Brazil.
,
Aline KANASHIRO 
22   Universidade Anhanguera, Campo Grande MS, Brazil.
,
Victor Gonçalves LOPES 
23   Hospital Federal dos Servidores do Estado, Departamento de Neurologia, São Paulo SP, Brazil.
,
Débora MAIA 
11   Universidade Federal de Minas Gerais, Hospital das Clínicas, Departamento de Neurologia, Belo Horizonte MG, Brazil.
,
Maria MANREZA 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Alberto Rolim Muro MARTINEZ 
24   Universidade Estadual de Campinas, Departamento de Neurologia, Campinas SP, Brazil.
,
Sandra Cristina Gonçalves MARTINEZ 
25   Hospital da Restauração, Departamento de Neurologia, Recife PE, Brazil.
,
Saulo Nardy NADER 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Luciana de Oliveira NEVES 
26   Hospital São Carlos, Fortaleza CE, Brazil.
,
Ivan Hideyo OKAMOTO 
19   Hospital Israelita Albert Einstein, São Paulo SP, Brazil.
,
Rogério Adas Ayres de OLIVEIRA 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Fabiano de Melo PEIXOTO 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Cristiana Borges PEREIRA 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Roberta Arb SABA 
27   Universidade Federal de São Paulo, Departamento de Neurologia, São Paulo SP, Brazil.
28   Hospital do Servidor Público Estadual, Departamento de Neurologia, São Paulo SP, Brazil.
,
Leticia Pereira de Brito SAMPAIO 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Lucas Porcello SCHILLING 
29   Pontifícia Universidade Católica do Rio Grande do Sul, São Lucas Hospital, Instituto do Cérebro, Porto Alegre RS, Brazil.
,
Marcus Tulius Teixeira SILVA 
30   Fundação Oswaldo Cruz, Rio de Janeiro RJ, Brazil.
,
Emanuelle Roberta SILVA 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
3   Hospital Sírio-Libanês, Núcleo de Neurociências, São Paulo SP, Brazil;
,
Jerusa SMID 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Cristiane Nascimento SOARES 
23   Hospital Federal dos Servidores do Estado, Departamento de Neurologia, São Paulo SP, Brazil.
,
Manoel SOBREIRA-NETO 
31   Universidade Federal do Ceará, Faculdade de Medicina, Departamento de Medicina Clínica, Fortaleza CE, Brazil.
,
Nise Alessandra de Carvalho SOUSA 
32   Hospital Universitário Getúlio Vargas, Departamento de Neuromuscular, Manaus AM, Brazil.
,
Leonardo Cruz de SOUZA 
33   Universidade Federal de Minas Gerais, Faculdade de Medicina, Grupo de Pesquisa em Neurologia Cognitiva e do Comportamento, Belo Horizonte MG, Brazil.
,
Hélio Afonso Ghizoni TEIVE 
34   Universidade Federal do Paraná, Hospital de Clínicas, Serviço de Neurologia, Curitiba PR, Brazil.
,
Vera Cristina TERRA 
35   Hospital Nossa Senhora das Graças, Epicentro, Curitiba PR, Brazil.
,
Matheus VALE 
36   Faculdade de Medicina do ABC, Departamento de Neurologia, Santo André SP, Brazil.
,
Vitor Mendes Grise VIEIRA 
36   Faculdade de Medicina do ABC, Departamento de Neurologia, Santo André SP, Brazil.
,
Edmar ZANOTELI 
1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
37   Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.
,
Gilmar PRADO 
27   Universidade Federal de São Paulo, Departamento de Neurologia, São Paulo SP, Brazil.
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ABSTRACT

Cannabinoids comprehend endocannabinoids, phytocannabinoids, and synthetic cannabinoids, with actions both in the central and peripherical nervous systems. A considerable amount of publications have been made in recent years, although cannabis has been known for over a thousand years. Scientific Departments from the Brazilian Academy of Neurology described evidence for medical use in their areas. Literature is constantly changing, and possible new evidence can emerge in the next days or months. Prescription of these substances must be discussed with patients and their families, with knowledge about adverse events and their efficacy.

RESUMO

Os canabinoides compreendem os endocanabinoides, fitocanabinoides e os canabinoides sintéticos e desempenham ações no sistema nervoso central e periférico. Uma quantidade enorme de publicações tem sido lançada nos últimos anos, embora a cannabis seja conhecida por milênios. Os Departamentos Científicos da Academia Brasileira de Neurologia descreveram as evidências do uso médico em suas áreas. A literatura está em constantes mudanças e possíveis novas evidências podem surgir nos próximos dias ou meses. A prescrição dessas substâncias deve ser discutida com os pacientes e suas famílias, com conhecimento sobre eventos adversos e sua eficácia.

Keywords:

Cannabis - Cannabinoids - Neurology - Cannabidiol

Palavras-chave:

Cannabis - Canabinoides - Neurologia - Canabidiol

Authors’ contribution:

SMDB: conceptualization, validation, writing - original draft. TA, CMOA, DCAA, RA, LMB, RB, AASC, WC, PPC, MDC, ABC, YCN, EE, MCFJ, CF, FVG, HRG, CGBH, AOK, FK, AK, VGL, DM, MM, ARMM, LON, IHO, RAAO, FMP, CBP, MTTS, ERS, JS, CNS, MSN, NACS, LCS, HAGT, VCT, MV, VMGV, EZ, RAS, LPBS, LPS: writing - original draft, writing - review and editing. SCGM, SNN: conceptualization, writing - original draft. GFP: conceptualization, validation.




Publication History

Received: 07 December 2020

Accepted: 08 December 2020

Article published online:
01 June 2023

© 2021. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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