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DOI: 10.1590/0004-282X-ANP-2020-0466
Epidemiological analysis of stroke patients with emphasis on access to acute-phase therapies
Análise epidemiológica de pacientes com AVC com ênfase no acesso às terapias de fase aguda
ABSTRACT
Background: Stroke is a public health problem. For patients with ischemic stroke, venous thrombolysis and mechanical thrombectomy are effective therapeutic options. However, even after the National Stroke Treatment Guidelines were published in 2012, the number of cases treated is still lower than expected. Objective: To identify the determining factors for obtaining access to acute-phase therapies in the state of Espírito Santo (ES) and investigate the profile of stroke patients treated at the Central State Hospital (HEC). Methods: Retrospective data from the medical records of 1078 patients from May 2018 to December 2019 were analyzed. Results: Among the 1,078 patients, 54.9% were men and the most prevalent age group was 60 to 79 years. Systemic arterial hypertension was the main single risk factor. Regarding treatment modality among the patients who arrived at the HEC within the therapeutic window, 47% received some type of acute-phase therapy. Waking up with the deficit was the main contraindication for venous thrombolysis in these cases. Conclusions: Application of the flowchart established by SESA-ES seemed to be effective for enabling responsiveness of care for stroke victims. Public emergency transport services had a fundamental role in this process. In addition, the care provided by the tertiary stroke center provided excellent access to acute-phase therapies. However, despite the efficiency of the service provided at the HEC, it only reached a maximum of 50% of the ES population. This service model therefore needs to be expanded throughout the state.
RESUMO
Antecedentes: O acidente vascular cerebral (AVC) é um problema de saúde pública. Nos casos de AVC isquêmico, a trombólise venosa e a trombectomia mecânica são efetivas opções terapêuticas de fase aguda. Entretanto, mesmo com a Diretriz Nacional de AVC publicada desde 2012, o número de casos tratados ainda é baixo. Objetivo: Apurar os fatores determinantes para o acesso às terapias de fase aguda na realidade espírito-santense e investigar o perfil dos pacientes de AVC atendidos no Hospital Estadual Central de Vitória (HEC). Métodos: O presente estudo analisou dados retrospectivos de prontuários de 1.078 pacientes no período de maio de 2018 a dezembro de 2019. Resultados: Dos 1.078 pacientes, 54,9% eram homens e a faixa etária mais prevalente foi a de 60 a 79 anos. A hipertensão arterial sistêmica foi o principal fator de risco isolado. Quanto ao tratamento, identificou-se que entre os pacientes que chegaram ao HEC na janela terapêutica 47% receberam terapia de fase aguda e que acordar com o déficit foi a principal contraindicação para trombólise venosa nesses casos. Conclusões: As análises demonstraram que a aplicação do fluxograma estabelecido pela Secretaria de Estado da Saúde do Espírito Santo parece ser eficaz na agilidade de atendimento das vítimas de AVC e que o Serviço de Atendimento Móvel de Urgência tem um papel fundamental nesse processo. Além disso, a assistência de um centro terciário de AVC permite acesso às terapias de fase aguda com excelência. Todavia, mesmo que o modelo de serviço prestado no HEC seja eficiente, ele atinge no máximo 50% da população do ES, sendo necessária a sua ampliação.
Authors’ contributions:
CFR, WGFN: bibliographic search, preparation and writing of the manuscript, participation in data analysis; ALP: bibliographic search, preparation of the manuscript, participation in data analysis; BCR, JDB: preparation of the manuscript, participation in data analysis; MS, VSN: guidance for execution and revision of the manuscript; LAB: guidance for execution of the manuscript; AFAP: writing and revision of the manuscript; CLM: guidance for execution and revision of the manuscript and participation in data analysis; JAFJ: guidance for the role process, bibliographic search, writing and revision of the manuscript and participation in data analysis.
Publication History
Received: 13 October 2020
Accepted: 13 March 2021
Article published online:
30 January 2023
© 2022. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Conass. 1 a cada 6 pessoas no mundo terá um AVC durante a sua vida. Conselhos nacional de secretários de saúde; 2015. Feb 1, 2021 Available at: https://www.conass.org.br/1-a-cada-6-pessoas-no-mundo-tera-um-avc-durante-a-sua-vida/
- 2 Tabnet. Datasus. 2019. Nov 8, 2019 Available at: http://tabnet.datasus.gov.br/cgi/tabcgi.exe?sim/cnv/obt10uf.def
- 3 Pinheiro HA, Vianna LG. Taxa de mortalidade específica por doenças cerebrovasculares no distrito federal entre 1995 e 2005. Rev Neurociênc 2012; Dec; 20 (04) 488-493 https://doi.org/10.4181/RNC.2012.20.483.6p
- 4 Almeida SRM. Análise epidemiológica do acidente vascular cerebral no brasil. Rev Neurociênc 2012; Dec; 20 (04) 481-482 https://doi.org/10.34024/rnc.2012.v20.8219
- 5 Goyal M, Menon BK, van Zwam WH, Dippel DWJ, Mitchell PJ, Demchuk AM. et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 2016; Apr;387(10029) 1723-1731 https://doi.org/10.1016/S0140-6736(16)00163-X
- 6 Sociedade Brasileira de Radiologia Intervencionista e Cirurgia Endovascular. Trombectomia endovascular. Aug 12, 2019 Available at: https://www.sobrice.org.br/a-sobrice
- 7 Mosley I, Nicol M, Donnan G, Patrick I, Dewey H. Stroke Symptoms and the Decision to Call for an Ambulance. Stroke 2007; Feb; 38 (02) 361-366 https://doi.org/10.1161/01.STR.0000254528.17405.cc
- 8 Ministério da Saúde, Manual de rotinas para atenção ao AVC MSE. Manual de rotinas para atenção ao AVC. primeira. Brasília: Ministério da Saúde; 2013: 1-54
- 9 Secretaria da Saúde do Estado do Espírito Santo. Abordagem aos Pacientes com Acidente Vascular Cerebral. 2018: 1-93 Feb 9, 2021 Available at: https://saude.es.gov.br/Media/sesa/Protocolo/Paciente%20com%20Acidente%20Vascular%20Cerebral.pdf
- 10 Panício MI, Mateus L, Ricarte IF, Figueiredo MM de, Fukuda TG, Seixas JC. et al. The influence of patient’s knowledge about stroke in Brazil: a cross sectional study. Arq Neuro-Psiquiatr 2014; Nov; 72 (12) 938-941 https://doi.org/10.1590/0004-282X20140167
- 11 Bensenor IM, Goulart AC, Szwarcwald CL, Vieira MLFP, Malta DC, Lotufo PA. Prevalence of stroke and associated disability in Brazil: National Health Survey - 2013. Arq Neuro-Psiquiatr 2015; Sep; 73 (09) 746-750 https://doi.org/10.1590/0004-282X20150115
- 12 Pontes-Neto OM, Cougo P, Martins SCO, Abud DG, Nogueira RG, Miranda M. et al. Brazilian guidelines for endovascular treatment of patients with acute ischemic stroke. Arq Neuro-Psiquiatr 2017; Jan; 75 (01) 50-56 https://doi.org/10.1590/0004-282X20160174
- 13 Locatelli MC, Furlaneto AF, Cattaneo TN. Epidemiological profile of patients with ischemic stroke treated in a Hospital. Rev Soc Bras Clín Méd 2017; 15 (03) 150-154 Aug 20, 2019 Available at: http://fi-admin.bvsalud.org/document/view/bne77
- 14 Guzik A, Bushnell C. Stroke Epidemiology and Risk Factor Management. Continuum (Minneap Minn) 2017; Feb;23(01) Cerebrovascular Disease 15-39 https://doi.org/10.1212/CON.20200466202004660416
- 15 Instituto Brasileiro de Geografia e Estatística. Censo 2010. Aug 12, 2019 Available at: https://censo2010.ibge.gov.br/sinopse/webservice/frm_piramide.php?codigo=32
- 16 Smajlović D. Strokes in young adults: epidemiology and prevention. Vasc Health Risk Manag 2015; Feb; 11: 157-164 https://doi.org/10.2147/VHRM.S53203
- 17 Instituto Brasileiro de Geografia e Estatística. Estimativas de População. Aug 20, 2019 Available at: https://ftp.ibge.gov.br/Estimativas_de_Populacao/Estimativas_2021/estimativa_dou_2021.pdf
- 18 Governo do Estado do Espírito Santo. Governo anuncia expansão dos SAMU 192. 2018. May 20, 2020 Available at: https://www.es.gov.br/Noticia/governo-anuncia-expansao-do-samu-192-2
- 19 Lecouturier J, Rodgers H, Murtagh MJ, White M, Ford GA, Thomson RG. Systematic review of mass media interventions designed to improve public recognition of stroke symptoms, emergency response and early treatment. MC Public Health 2010; Dec; 10 (01) 784-784 https://doi.org/10.1186/1471-2458-10-784
- 20 Passos VMA, Ishitani LH, Franco GC, Lana GC, Abreu DMX, Marinho M de F. et al. Consistent declining trends in stroke mortality in Brazil: mission accomplished?. Arq Neuro-Psiquiatr 2016; May; 74 (05) 376-381 https://doi.org/10.1590/0004-282X20160055
- 21 The National Institute of Neurological Disorders and Stroke rt-PA troke Study Group. Tissue Plasminogen Activador for Acute Ischemic Stroke. N Engl J Med 1995; Dec; 333 (24) 1581-1587 https://doi.org/10.1056/NEJM199512143332401
- 22 Garritano CR, Luz PM, Pires MLE, Barbosa MTS, Batista KM. Análise da tendência da mortalidade por acidente vascular cerebral no Brasil no século XXI. Arq Bras Cardiol 2012; Jun; 98 (06) 519-527 https://doi.org/10.1590/S0066-782X2012005000041
- 23 Lahr MMH, Luijckx G-J, Vroomen PCAJ, van der Zee D-J, Buskens E. Proportion of patients treated with thrombolysis in a centralized versus a decentralized acute stroke care setting. Stroke 2012; May; 43 (05) 1336-1340 https://doi.org/10.1161/STROKEAHA.111.641795
- 24 Scherf S, Limburg M, Wimmers R, Middelkoop I, Lingsma H. Increase in national intravenous thrombolysis rates for ischaemic stroke between 2005 and 2012: is bigger better?. BMC Neurol 2016; Apr; 16: 53-53 https://doi.org/10.1186/s12883-016-0574-7
- 25 Sheth SA, Lopez-Rivera V, Lee S, Savitz SI, Liebeskind DS, Grotta JC. et al. 14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy: Proceedings and summary of discussions. Int J Stroke 2019; Jun; 14 (04) 439-441 https://doi.org/10.1177/1747493019838760
- 26 Jovin TG, Saver JL, Ribo M, Pereira V, Furlan A, Bonafe A. et al. Diffusion-weighted imaging or computerized tomography perfusion assessment with clinical mismatch in the triage of wake up and late presenting strokes undergoing neurointervention with Trevo (DAWN) trial methods. Int J Stroke 2017; Aug; 12 (06) 641-652 https://doi.org/10.1177/1747493017710341
- 27 Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E. et al. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014; Nov;384(9958) 1929-1935 https://doi.org/10.1016/S0140-6736(14)60584-5
- 28 Kurz MW, Advani R, Behzadi GN, Eldøen G, Farbu E, Kurz KD. Wake-up stroke-Amendable for thrombolysis-like stroke with known onset time?. Acta Neurol Scand 2017; Jul; 136 (01) 4-10 https://doi.org/10.1111/ane.12686
- 29 Jovin TG, Saver JL, Ribo M, Pereira V, Furlan A, Bonafe A. et al. Diffusion-weighted imaging or computerized tomography perfusion assessment with clinical mismatch in the triage of wake up and late presenting strokes undergoing neurointervention with Trevo (DAWN) trial methods. Int J Stroke 2017; Aug; 12 (06) 641-652 https://doi.org/10.1177/1747493017710341
- 30 Raffin CN, Fernandes JG, Evaristo EF, Siqueira Neto JI, Friedrich M, Puglia P. et al. Revascularização clínica e intervencionista no acidente vascular cerebral isquêmico agudo: opinião nacional. Arq Neuro-Psiquiatr 2006; Jun;64(2A) 342-348 https://doi.org/10.1590/S0004-282X2006000200034