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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2016; 74(02): 93-98
DOI: 10.1590/0004-282X20160005
ARTICLE

Extratemporal abnormalities in phosphorus magnetic resonance spectroscopy of patients with mesial temporal sclerosis

Anormalidades extratemporais na espectroscopia de fósforo por ressonância magnética em pacientes com esclerose mesial temporal
Eun Joo Park
1   Universidade de São Paulo, Faculdade de Medicina, Departamento de Radiologia, Sao Paulo SP, Brazil;
,
Maria Concepción Garcia Otaduy
1   Universidade de São Paulo, Faculdade de Medicina, Departamento de Radiologia, Sao Paulo SP, Brazil;
,
Katarina Paz de Lyra
1   Universidade de São Paulo, Faculdade de Medicina, Departamento de Radiologia, Sao Paulo SP, Brazil;
,
Celi Santos Andrade
1   Universidade de São Paulo, Faculdade de Medicina, Departamento de Radiologia, Sao Paulo SP, Brazil;
,
Luiz Henrique Martins Castro
2   Universidade de São Paulo, Faculdade de Medicina, Departamento de Neurologia, Sao Paulo SP, Brazil;
,
Valmir Passarelli
2   Universidade de São Paulo, Faculdade de Medicina, Departamento de Neurologia, Sao Paulo SP, Brazil;
,
Rosa Maria Figueiredo Valerio
2   Universidade de São Paulo, Faculdade de Medicina, Departamento de Neurologia, Sao Paulo SP, Brazil;
,
Carmen Lisa Jorge
2   Universidade de São Paulo, Faculdade de Medicina, Departamento de Neurologia, Sao Paulo SP, Brazil;
,
Miriam Harumi Tsunemi
3   Universidade Estadual Paulista Júlio de Mesquita Filho, Instituto de Biociências, Botucatu SP, Brazil.
,
Claudia da Costa Leite
1   Universidade de São Paulo, Faculdade de Medicina, Departamento de Radiologia, Sao Paulo SP, Brazil;
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ABSTRACT

Objective We evaluated extratemporal metabolic changes with phosphorus magnetic resonance spectroscopy (31P-MRS) in patients with unilateral mesial temporal sclerosis (MTS).

Method 31P-MRS of 33 patients with unilateral MTS was compared with 31 controls. The voxels were selected in the anterior, posterior insula-basal ganglia (AIBG, PIBG) and frontal lobes (FL). Relative values of phosphodiesters- PDE, phosphomonoesters-PME, inorganic phosphate - Pi, phosphocreatine- PCr, total adenosine triphosphate [ATPt = γ- + a- + b-ATP] and the ratios PCr/ATPt, PCr/γ-ATP, PCr/Pi and PME/PDE were obtained.

Results We found energetic abnormalities in the MTS patients compared to the controls with Pi reduction bilaterally in the AIBG and ipsilaterally in the PIBG and the contralateral FL; there was also decreased PCr/γ-ATP in the ipsilateral AIBG and PIBG. Increased ATPT in the contralateral AIBG and increased γ-ATP in the ipsilateral PIBG were detected.

Conclusion Widespread energy dysfunction was detected in patients with unilateral MTS.

RESUMO

Objetivo Nós avaliamos as alterações metabóblicas através da espectroscopia de fósforo por ressonância magnética (31P-MRS) em pacientes com esclerose mesial temporal (EMT) unilateral.

Método 31P-MRS de 33 pacientes com EMT unilateral foram comparadas aos de 31 controles. Foram selecionados os voxels nas regiões insulonuclear anterior e posterior (RINA e RINP) e frontal (RF). Os valores relativos de fosfodiésteres – PDE, fosfomonoésteres- PME, fosfato inorgânico- Pi, fosfocreatina –PCr, adenosina trifosfato total [ATPt = γ- + a- + b-ATP] e as razões PCr/ATPt, PCr/γ-ATP, PCr/Pi e PME/PDE foram obtidas.

Resultados Nós encontramos anormalidades em pacientes com EMT em comparação aos controles. Redução de Pi nas RINA bilateralmente, RINP ipsilateral e RF contralateral, redução de PCr/γ-ATP nas RINA e RINP ipsilaterais foram detectadas. Aumentos de ATPT na RINA contralateral e aumento de γ-ATP na RINP ipsilateral também foram encontradas.

Conclusão Disfunção energética difusa foi encontrada em pacientes com EMT unilateral.

phosphorus spectroscopy - magnetic resonance imaging - neurometabolism - mesial temporal sclerosis - epilepsy
espectroscopia de fósforo - ressonância magnética - neurometabolismo - esclerose mesial temporal - epilepsia


Publikationsverlauf

Eingereicht: 19. Juni 2015

Angenommen: 26. Oktober 2015

Artikel online veröffentlicht:
06. September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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