Work and power reduced in L-dopa naïve patients in the early-stages of Parkinson’s disease

Lidiane Oliveira Lima; Francisco Cardoso; Luci Fuscaldi Teixeira-Salmela; Fátima Rodrigues-de-Paula

doi:10.1590/0004-282X20160014

Arquivos de Neuro-Psiquiatria, Table of Contents

CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2016; 74(04): 287-292
DOI: 10.1590/0004-282X20160014

ARTICLE

Work and power reduced in L-dopa naïve patients in the early-stages of Parkinson’s disease

Trabalho e potência reduzidos em indivíduos com doença de Parkinson sem L-dopa nos estágios iniciais

Lidiane Oliveira Lima

¹Universidade Federal do Ceará,Departamento de Fisioterapia,FortalezaCE,Brazil;

,

Francisco Cardoso

²Universidade Federal de Minas Gerais,Departamento de Clínica Médica,Belo HorizonteMG,Brazil;

,

Luci Fuscaldi Teixeira-Salmela

³Universidade Federal de Minas Gerais,Departamento de Fisioterapia,Belo HorizonteMG,Brazil.

,

Fátima Rodrigues-de-Paula

³Universidade Federal de Minas Gerais,Departamento de Fisioterapia,Belo HorizonteMG,Brazil.

› Author Affiliations

Abstract

ABSTRACT

Studies which have investigated muscular performance during the initial stages of Parkinson´s disease (PD) without L-dopa treatments were not found.

Objective to assess whether muscular performance, work and power, of the trunk and lower limbs in L-dopa naïve patients in the early stages of PD was lower than those of healthy subjects and to compare muscular performance between the lower limbs.

Method Ten subjects with PD, Hoehn and Yahr (HY) I-II, L-dopa naïve and 10 subjects in the control group were assessed with the isokinetic dynamometer.

Results ANOVAs revealed that work and power measures of the trunk, hip, knee, and ankle muscular groups were lower in PD compared with the control group (p < 0.05). There were no significant differences in muscular performance between the lower limbs.

Conclusion The results suggested the use of specific exercises, as rehabilitation strategies, to improve the ability to produce work and power with this population.

RESUMO

Estudos que investigaram o desempenho muscular durante os estágios iniciais da doença de Parkinson (DP), sem tratamento com L-dopa não foram encontrados.

Objetivo Avaliar se o desempenho muscular, por meio de medidas de trabalho e potência, do tronco e dos membros inferiores em pacientes sem o uso de L-dopa nas fases iniciais da DP é menor do que o de indivíduos saudáveis e comparar o desempenho muscular entre os membros inferiores.

Método Dez indivíduos com DP, Hoehn and Yahr (HY) I-II, sem L-dopa e 10 indivíduos do grupo controle foram avaliados com o dinamçmetro isocinético.

Resultados Medidas de trabalho e potência muscular do tronco, quadril, joelho, tornozelo foram menores no PD em comparação com o grupo controle (p < 0,05) e não houve diferenças significativas no desempenho muscular entre os membros inferiores.

Conclusão O uso de exercícios específicos, como estratégias de reabilitação, pode melhorar a capacidade de produzir trabalho e potência muscular nesta população.

Parkinson’s disease - muscle strength - Muscle strength dynamometer - rehabilitation - physical therapy speciality

doença de Parkinson - força muscular - Dinamçmetro de força muscular - reabilitação - fisioterapia

Full Text

References

References
1 Allen NE, Canning CG, Sherrington C, Fung VSC. Bradykinesia, muscle weakness and reduced muscle power in Parkinson’s disease. Mov Disord. 2009;24(9):1344-51. doi:10.1002/mds.22609
2 Allen NE, Sherrington C, Canning CG, Fung VSC. Reduced muscle power is associated with slower walking velocity and falls in people with Parkinson’s disease. Parkinsonism Relat Disord. 2010;16(4):261-4. doi:10.1016/j.parkreldis.2009.12.011
3 Nogaki H, Kakinuma S, Morimatsu M. Movement velocity dependent muscle strength in Parkinson´s disease. Acta Neurol Scand. 1999;99(3):152-7. doi:10.1111/j.1600-0404.1999.tb07337.x
4 Nogaki H, Kakinuma S, Morimatsu M. Muscle weakness in Parkinson’s disease: a follow-up study. Parkinsonism Relat Disord. 2001;8(1):57-62. doi:10.1016/S1353-8020(01)00002-5
5 Keus SHJ, Munneke M, Graziano M, Paltamaa J, Pelosin E, Domingos J, Brühlmann S, Ramaswamy B, Prins J, Struiksma C, Rochester L, Nieuwboer A, Bloem B. European physiotherapy Guideline for Parkinson’s disease. ParkinsonNet. 2014, the Netherlands. http://parkinsonnet.info/media/14741616/eu_guideline_parkinson_201412_clinicians.pdf
6 Bugalho P, Viana-Baptista M. Predictors of cognitive decline in the early stages of Parkinson’s disease: a brief cognitive assessment longitudinal study. Parkinson’s Disease; 2013;2013:ID912037. doi:10.1155/2013/912037
7 Trujillo JP, Gerrits NJ, Vriend C, Bendse HW, Heuvel OA, Werf YD. Impaired planning in Parkinson’s disease is reflected by reduced brain activation and connectivity. Hum Brain Mapp. 2015;36(9):3703-15. doi:10.1002/hbm.22873
8 Song J, Sigward S, Fisher B, Salem GJ. Altered dynamic postural control during step turning in persons with early-stage Parkinson’s disease. Parkinson Dis. 2012;2012:ID386962. doi:10.1155/2012/386962
9 Carpinella I, Crenna P, Calabrese E, et al. Locomotor function in the early stage of Parkinson’s disease. IEEE Trans Neural Syst Rehabil Eng. 2007;15(4):543-51. doi:10.1109/TNSRE.2007.908933
10 Bridgewater KJ, Sharpe MH. Trunk muscle performance in early Parkinson’s disease. Phys Ther. 1998; 78(6):566-76.
11 Koller W, Kase S. Muscle strength testing in Parkinson´s disease. Eur Neurol. 1986;25(2):130-3. doi:10.1159/000115998
12 Kakinuma S, Nogaki H, Pramanik B, Morimatsu M. Muscle weakness in Parkinson’s disease: isokinetic study of the lower limbs. Eur Neurol. 1998;39(4):218-22. doi:10.1159/000007937
13 Nogaki H, Fukusako T, Sasabe F, Negoro K, Morimatsu M. Muscle strength in early Parkinson’s Disease. Mov Disord. 1995;10(2):225-6. doi:10.1002/mds.870100218
14 Charteris J. Effects of velocity on upper to lower extremity muscular work and power output ratios of intercollegiate athletes. Br J Sports Med. 1999;33(4):250-4. doi:10.1136/bjsm.33.4.250
15 Fellows SJ, Noth J. Grip force abnormalities in de novo Parkinson’s disease. Mov Disord. 2004;19(5):560-5. doi:10.1002/mds.10710
16 Canning CG. Rehabilitation in Parkinson’s disease: the challenge to provide early and ongoing, evidence-based, patient-centred care. Arq Neuropsiquiatr. 2013;71(12):917-9. doi:10.1590/0004-282X20130228
17 DeLong MR. Primate models of movement disorders of basal ganglia origin. Trends Neurosci. 1990;13(7):281-5. doi:10.1016/0166-2236(90)90110-V
18 Goetz CG, Poewe W, Rascol O, Sampaio C, Stebbins GT, Counsell C et al. Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov Disord. 2004;19(9):1020-8. doi:10.1002/mds.20213
19 Centers for Disease Control and Prevention. Physical activity trends: United States (1990-1998). MMWR. 2001;50(9):166-9.
20 Folstein MF, Folstein SE, McHugh PR. “Mini Mental State”: a practical method for grading the cognitive state of patients for the clinican. J Psychiatr Res. 1995;12(3):189-98. doi:10.1016/0022-3956(75)90026-6
21 Fahn S, Elton R. Unified Parkinson’s disease rating scale. In: Fahn S, Marsden CD, Calne DB, Goldstein M, eds. Recent Developments in Parkinson’s Disease, Vol 2. Florham Park, NJ. Macmillan Health Care Information 1987, 153-163, 293-304.
22 Corcos DM, Chen CM, Quinn NP, McAuley J, Rothwell JC. Strength in Parkinson’s disease: relationship to rate of force generation and clinical status. Ann Neurol. 1996;39(1):79-88. doi:10.1002/ana.410390112
23 Inkster LM, Eng JJ, MacIntyre DL, Stoessl AJ. Leg muscle strength is reduced in Parkinson’s disease and relates to the ability to rise from a chair. Mov Disord. 2003;18(2):157-62. doi:10.1002/mds.10299
24 Papegaaij S, Taube W, Baudry S, Otten E, Hortobágyi T. Aging causes a reorganization of cortical and spinal control of posture. Fr.ont Aging Neurosci. 2014;6:28. doi:10.3389/fnagi.2014.00028
25 Rossi B, Siciliano G, Carboncini MC, Manca ML, Massetani R, Viacava P et al. Muscle modifications in Parkinson’s disease: myoelectric manifestations. Electroencephalogr Clin Neurophysiol. 1996;101(3):211-8. doi:10.1016/0924-980X(96)94672-X
26 Moreno Catalá M, Woitalla D, Arampatzis A. Central factors explain muscle weakness in young fallers with Parkinson’s disease. Neurorehabil Neural Repair. 2013;27(8):753-9. doi:10.1177/1545968313491011
27 Nallegowda M, Singh U, Handa G, Khanna M, Wadhwa S, Yada SL et al. Role of sensory input and muscle strength in maintenance of balance, gait, and posture in Parkinson’s disease. Am J Phys Med Rehabil. 2004;83(12):898-908. doi:10.1097/01.PHM.0000146505.18244.43
28 Pedersen SW, Öberg B. Dynamic strength in Parkinson’s disease: Quantitative measurements following withdrawal of medication. Eur Neurol. 1992;33(2):97-102. doi:10.1159/000116913
29 Kempster PA, Gibb WR, Stern GM, Lees AJ. Asymmetry of substantia nigra neuronal loss in Parkinson’s disease and its relevance to the mechanism of levodopa related motor fluctuations. J Neurol Neurosurg Psychiatry. 1989;52(1):72-6. doi:10.1136/jnnp.52.1.72
30 Frazzitta G, Ferrazzoli D, Maestri R, Rovescala R, Guaglio G, Bera R et al. Differences in muscle strength in parkinsonian patients affected on the right and left side. PLoS One. 2015;10(3):E0121251. doi:10.1371/journal.pone.0121251
31 Giladi N. Mobility and exercise in movement disorders. Parkinsonism Relat Disord. 2009;15 Suppl 3:S46-8. doi:10.1016/S1353-8020(09)70033-1
32 Corcos DM, Robichaud JA, David FJ, Leurgans SE, Vaillancourt DE, Poon C et al. A two-year randomized controlled trial of progressive resistance exercise for Parkinson’s disease. Mov Disord. 2013;28(9):1230-40. doi:10.1002/mds.25380