Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect

ABSTRACT

Purpose of the study was evaluate the possible antinociceptive effect of botulinum neurotoxin type-A (BoNT/A) in an experimental model of trigeminal neuralgia.

Method Neuropathic pain was induced by surgical constriction of the infraorbital nerve in rats. A control group underwent a sham procedure consisting of surgical exposure of the nerve. Subgroups of each group received either BoNT/A or isotonic saline solution. The clinical response was assessed with the -20°C test. Animals that underwent nerve constriction developed sensitization; the sham group did not.

Results The sensitization was reversed by BoNT/A treatment evident 24 hours following application. Pronociceptive effect was observed in the sham group following BoNT/A.

Conclusion BoNT/A has an antinociceptive effect in sensitized animals and a pronociceptive effect in non-sensitized animals.

RESUMO

A proposta do estudo foi avaliar o efeito antinociceptivo da neurotoxina botulínica do tipo A (BoNT/A) em um modelo experimental de nevralgia trigeminal.

Método O grupo estudo foi obtido através da constrição do nervo infraorbital em ratos e o grupo controle pela simples exposição deste nervo. Cada um dos grupos foram subdivididos de acordo com o tratamento realizado após a intervenção cirurgica: solução salina isotçnica ou BoNT/A. A resposta terapêutica foi avaliada através do teste de -20°C.

Resultados Animais com constrição do nervo desenvolveram uma sensibilização nociceptiva quando comparados ao grupo controle. Ela foi revertida após 24 horas utilizando BoNT/A. O efeito pronociceptivo foi observado no grupo controle após a administração de BoNTA.

Conclusão BoNT/A apresenta um efeito antinociceptivo em animais sensibilizados e pronociceptivo em animals não sensibilizados.

analgesics - botulinum toxins - facial pain - trigeminal neuralgia

analgésicos - toxinas botulínicas - dor facial - nervo infraorbital - neuralgia do trigêmeo

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