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DOI: 10.1590/0004-282X20160090
Safety of switching from natalizumab straight into fingolimod in a group of JCV-positive patients with multiple sclerosis
Segurança na mudança direta de natalizumabe para fingolimode em um grupo de pacientes com esclerose múltipla e positivos para JCVABSTRACT
Objective To assess safety of the switch between natalizumab and fingolimod without a washout period.
Methods Prospective data on 25 JCV positive patients who underwent this medication switch were collected and analyzed.
Results After a median period of nine months from the medication switch, there were no safety issues to report. The patients had good disease control and no adverse events were reported.
Conclusion Washout may not be necessary in daily practice when switching from natalizumab to fingolimod. Expertise on multiple sclerosis management, however, is essential for drug switching.
RESUMO
Objetivo Avaliar a segurança na mudança entre natalizumabe e fingolimode sem período de washout.
Métodos Dados prospectivos de 25 pacientes positivos para vírus JC que tiveram sua medicação modificada foram coletados e analisados.
Resultados Após uma mediana de nove meses da troca de medicação, não havia aspectos de segurança a relatar. Os pacientes estavam com bom controle da doença e não foram relatados eventos adversos.
Conclusão Washout pode não ser necessário na prática diária para a mudança entre natalizumabe e fingolimode. No entanto, expertise no manejo de esclerose múltipla é essencial para esta troca entre medicações.
Publication History
Received: 13 January 2016
Accepted: 24 May 2016
Article published online:
06 September 2023
© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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