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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2016; 74(08): 626-631
DOI: 10.1590/0004-282X20160096
ARTICLES

Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients

Níveis séricos de adiponectina, CCL3/MIP-1α e CCL5/RANTES discriminam pacientes com migrânea e cefaleia do tipo tensional
Renan B. Domingues
1   Universidade Federal de Minas Gerais, Programa de Neurociências, Belo Horizonte MG, Brasil;
2   Senne Liquor Diagnóstico, São Paulo SP, Brasil;
,
Halina Duarte
1   Universidade Federal de Minas Gerais, Programa de Neurociências, Belo Horizonte MG, Brasil;
,
Carlos Senne
2   Senne Liquor Diagnóstico, São Paulo SP, Brasil;
3   Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte MG, Brasil;
,
Gustavo Bruniera
2   Senne Liquor Diagnóstico, São Paulo SP, Brasil;
3   Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte MG, Brasil;
,
Fernando Brunale
2   Senne Liquor Diagnóstico, São Paulo SP, Brasil;
3   Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório Interdisciplinar de Investigação Médica, Belo Horizonte MG, Brasil;
,
Natália P. Rocha
4   Hospital Israelita Albert Einstein, Laboratório de Patologia Clínica, São Paulo SP, Brasil.
,
Antonio L. Teixeira
1   Universidade Federal de Minas Gerais, Programa de Neurociências, Belo Horizonte MG, Brasil;
4   Hospital Israelita Albert Einstein, Laboratório de Patologia Clínica, São Paulo SP, Brasil.
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ABSTRACT

Objectives Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache.

Methods This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded.

Results We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain.

Conclusions This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches.

RESUMO

Objetivos Moléculas inflamatórias e fatores neurotróficos estão implicados na modulação dolorosa, contudo, seu papel nas cefaleias primárias não é claro. O objetivo do presente estudo foi comparar níveis de biomarcadores séricos na migrânea e cefaleia do tipo tensional.

Métodos Este foi um estudo transversal, no qual foram avaliados níveis de adiponectina, quimiocinas e fatores neurotróficos em pacientes com migrânea e cefaleia do tipo tensional. Sintomas depressivos e ansiosos, o impacto e a frequência da cefaleia e alodínea foram registrados.

Resultados Foram incluídos 68 pacientes com migrânea e 48 pacientes com cefaleia do tipo tensional. A alodínia cutânea (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), e adiponectina (p = 0.017) foram maiores na migrânea, independentemente de sintomas depressivos e ansiosos, frequência e impacto da cefaleia.

Conclusões Níveis de CCL3/MIP-1α, CCL5/RANTES e adiponectina foram maiores na migrânea do que na cefaleia do tipo tensional, sugerindo papeis distintos destas moléculas na fisiopatologia destas duas cefaleias primárias.

migraine disorders - tension-type headache - adiponectin - chemokines - neurotrophic factors
transtornos de enxaqueca - cefaleia do tipo tensional - adiponectina - quimiocinas - fatores neurotróficos

Support:

Support: This work was funded by CNPq and Fapemig, Brazil.




Publikationsverlauf

Eingereicht: 16. September 2015

Angenommen: 25. Mai 2016

Artikel online veröffentlicht:
06. September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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