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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2016; 74(10): 849-854
DOI: 10.1590/0004-282X20160117
VIEW AND REVIEW

Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis

Muito além do neurçnio motor: o papel das células da glia na esclerose lateral amiotrófica
Paulo Victor Sgobbi de Souza
1   Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
,
Wladimir Bocca Vieira de Rezende Pinto
1   Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
,
Flávio Moura Rezende Filho
1   Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
,
Acary Souza Bulle Oliveira
1   Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, Brasil.
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ABSTRACT

Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.

RESUMO

A doença do neurçnio motor constitui um dos principais grupos de doenças neurodegenerativas, representadas principalmente pela esclerose lateral amiotrófica. Apesar dos amplos dados genéticos e bioquímicos em relação aos seus mecanismos fisiopatológicos, a doença do neurçnio motor se desenvolve sob uma complexa rede de mecanismos não restritos às funções particulares dos neurçnios motores alfa, mas, na verdade, envolvendo diversas funções interativas das células da glia. Esta revisão tem como objetivo expor alguns dos principais papéis das células da glia nos mecanismos fisiológicos de interações neurçnio-glia e os mecanismos relacionados à sobrevivência do neurçnio motor ligados a funções das células da glia.

motor neurons - astrocyte - microglia - amyotrophic lateral sclerosis - motor neuron disease
neurçnios motores - astrócitos - microglia - esclerose lateral amiotrófica - doença do neurçnio motor


Publication History

Received: 28 February 2016

Accepted: 13 June 2016

Article published online:
06 September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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