Working memory and left medial temporal cortical thickness

Giuseppe Pastura; Tadeu Takao Almodovar Kubo; Maria Angélica Regalla; Cíntia Machado Mesquita; Gabriel Coutinho; Emerson Leandro Gasparetto; Otávio Figueiredo; Paulo Mattos; Alexandra Prüfer de Queiroz Campos Araújo

doi:10.1590/0004-282X20160123

Arquivos de Neuro-Psiquiatria, Table of Contents

CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2016; 74(10): 785-790
DOI: 10.1590/0004-282X20160123

ARTICLE

Working memory and left medial temporal cortical thickness

Memória de trabalho e espessura cortical temporal medial esquerda

Giuseppe Pastura

¹Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Departamento de Pediatria, Rio de Janeiro RJ, Brasil;

,

Tadeu Takao Almodovar Kubo

²Clínica de Diagnóstico por Imagem (CDPI), Rio de Janeiro RJ, Brasil;

,

Maria Angélica Regalla

³Universidade Federal do Rio de Janeiro, Instituto de Psiquiatria, Rio de Janeiro RJ, Brasil;

,

Cíntia Machado Mesquita

³Universidade Federal do Rio de Janeiro, Instituto de Psiquiatria, Rio de Janeiro RJ, Brasil;

,

Gabriel Coutinho

⁴Centro de Neuropsicologia Aplicada/Instituto D`Or, Rio de Janeiro RJ, Brasil;

,

Emerson Leandro Gasparetto

⁵Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Departamento de Radiologia, Rio de Janeiro RJ, Brasil;

,

Otávio Figueiredo

⁶Universidade Federal do Rio de Janeiro, Instituto COPPEAD, Rio de Janeiro RJ, Brasil;

,

Paulo Mattos

⁷Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Departamento de Psiquiatria, Rio de Janeiro RJ, Brasil.

,

Alexandra Prüfer de Queiroz Campos Araújo

¹Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Departamento de Pediatria, Rio de Janeiro RJ, Brasil;

› Author Affiliations

Abstract

ABSTRACT

Objective

To perform a pilot study to investigate the association between working memory and cortical thickness in a sample of attention deficit/hyperactivity disorder (ADHD) children.

Methods

Seventeen children aged 7-10 years diagnosed with ADHD and 16 healthy children underwent a magnetic resonance scan for cortical thickness measurements. Data was correlated with working memory performance using the Backwards Digit Span subtest of the Wechsler Intelligence Scale for Children.

Results

Working memory impairment, evidenced by lower scores on the Backwards Digit Span, was observed in patients with ADHD compared to healthy controls. There was a direct correlation between working memory and cortical thickness of the left medial temporal lobe (Spearman’s correlation coefficient: 0.499; p < 0.005).

Conclusions

Our data suggests, for the first time, a correlation between working memory, evaluated by the Backwards Digit Span, and left medial temporal cortical thickness.

RESUMO

Objetivo

Realizar estudo piloto para investigar a associação entre memória de trabalho e espessura cortical em crianças com transtorno de défict de atenção e hiperatividade (TDAH).

Métodos

Dezessete crianças com TDAH, entre 7 e 10 anos, e dezesseis crianças saudáveis foram submetidas a ressonância magnética para aferição de espessura cortical. Os dados foram correlacionados com desempenho da memória de trabalho usando a ordem inversa do subteste Dígitos da Escala de Inteligência Wechsler para Crianças.

Resultados

Prejuízos na memória de trabalho, evidenciado pela menor pontuação na ordem inversa do subteste Dígitos, foram observados em pacientes com TDAH, em comparação com crianças saudáveis. Observou-se correlação direta entre memória de trabalho e espessura do lobo temporal médio à esquerda (coeficiente de correlação de Spearman: 0,499; p < 0,005).

Conclusões

Nossos dados sugerem, pela primeira vez, uma correlação entre memória de trabalho, avaliada através da pontuação na ordem inversa do subteste Dígitos, e espessura do córtex temporal medial à esquerda.

attention deficit disorder with hyperactivity - child - memory

transtorno do déficit de atenção com hiperatividade - criança - memória

Full Text

References

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