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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2016; 74(10): 823-828
DOI: 10.1590/0004-282X20160130
ARTICLES

The maintenance of modified electroconvulsive therapy combined with risperidone is better than risperidone alone in preventing relapse of schizophrenia and improving cognitive function

Manutenção de eletroconvulsoterapia modificada combinada com risperidona é melhor do que a risperidona isoladamente na prevenção de recidivas de esquizofrenia e melhoras da função cognitiva
Ying Yang   *
1   Shandong University, Shandong Province, China;
2   Shandong Mental Health Center, Department of Psychiatry, Shandong Province, China;
,
Xiaojing Cheng   *
2   Shandong Mental Health Center, Department of Psychiatry, Shandong Province, China;
,
Qingzhi Xu
2   Shandong Mental Health Center, Department of Psychiatry, Shandong Province, China;
,
Renjun Li
2   Shandong Mental Health Center, Department of Psychiatry, Shandong Province, China;
,
Zengxun Liu
2   Shandong Mental Health Center, Department of Psychiatry, Shandong Province, China;
,
Liping Wang
2   Shandong Mental Health Center, Department of Psychiatry, Shandong Province, China;
,
Yanqing Zhang
3   Qilu Children’s Hospital of Shandong University, Department of Pediatrics, Shandong Province, China.
,
Guoqiang Ren
2   Shandong Mental Health Center, Department of Psychiatry, Shandong Province, China;
,
Jintong Liu
1   Shandong University, Shandong Province, China;
2   Shandong Mental Health Center, Department of Psychiatry, Shandong Province, China;
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ABSTRACT

Objective To evaluate the effect of maintenance modified electroconvulsive therapy (MECT) on schizophrenic patients.

Methods From June 2012 to June 2014, 62 patients with schizophrenia, who had recovered from a successful course of acute MECT, were recruited. Thirty-one patients received maintenance MECT and risperidone, as the experimental group. Another 31 patients were enrolled in the control group, and received risperidone only. The effects on cognitive functions, clinical symptoms and relapse rate were determined.

Results Patients in the experimental group had a lower relapse rate and longer relapse-free survival time than the controls. Relative to the baseline evaluation, patients showed statistically significant improvement in verbal memory and visual memory. At the final assessment, the scores of verbal and visual memory were remarkably lower in the experimental group than the controls but there was no significant difference in other tests.

Conclusion Maintenance MECT plus medication is superior to medication alone in preventing relapse and improving cognitive function.

RESUMO

Objetivo Avaliar o efeito da manutenção de eletroconvulsoterapia modificada (ECTM) em pacientes com esquizofrenia.

Métodos Entre junho de 2012 a junho de 2014, 62 pacientes, com esquizofrenia e que apresentaram recuperação bem-sucedida após ECTM aguda, foram recrutados. Um grupo experimental de trinta e um pacientes recebeu ECTM de manutenção e risperidona. Os demais pacientes foram incluídos no grupo controle, recebendo apenas a risperidona. Determinou-se os efeitos sobre as funções cognitivas, os sintomas clínicos e a taxa de recidiva.

Resultados Os pacientes do grupo experimental tiveram menor taxa de recidiva e maior tempo de sobrevida livre de recidiva do que os do grupo controle. Em relação à avaliação inicial, os pacientes apresentaram melhora estatisticamente significativa da memória verbal e da memória visual. Na avaliação final, os escores de memória verbal e visual foram extraordinariamente menores no grupo experimental do que no grupo controle, mas não se observou diferenças significativas em outros testes.

Conclusão A ECTM de manutenção combinada à medicação é superior ao uso apenas de medicação na prevenção de recidivas e na melhora da função cognitiva.

schizophrenia - electroconvulsive therapy - risperidone - cognition
esquizofrenia - eletroconvulsoterapia - risperidona - cognição

* Equal contributors and co-first authors




Publication History

Received: 04 April 2016

Accepted: 15 June 2016

Article published online:
06 September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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