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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2017; 75(02): 123-126
DOI: 10.1590/0004-282X20160189
VIEW AND REVIEW

Dengue infection in the nervous system: lessons learned for Zika and Chikungunya

Infecção por dengue no sistema nervoso: lições para Zika e Chikungunya
Marzia Puccioni-Sohler
1   Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Escola de Medicina e Cirurgia, Hospital Universitário Gaffree e Guinle, Rio de Janeiro RJ, Brasil;
2   Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Pós-graduação em Doenças Infecciosas e Parasitárias, Rio de Janeiro RJ, Brasil;
,
Natalia Roveroni
1   Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Escola de Medicina e Cirurgia, Hospital Universitário Gaffree e Guinle, Rio de Janeiro RJ, Brasil;
,
Carolina Rosadas
2   Universidade Federal do Rio de Janeiro (UFRJ), Faculdade de Medicina, Pós-graduação em Doenças Infecciosas e Parasitárias, Rio de Janeiro RJ, Brasil;
,
Fernando Ferry
1   Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Escola de Medicina e Cirurgia, Hospital Universitário Gaffree e Guinle, Rio de Janeiro RJ, Brasil;
,
Jose Mauro Peralta
3   Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Microbiologia Professor Paulo de Góes, Rio de Janeiro RJ, Brasil;
,
Amilcar Tanuri
4   Universidade Federal do Rio de Janeiro (UFRJ), Instituto de Biologia, Rio de Janeiro RJ, Brasil.
› Author AffiliationsSupport: Fundação Carlos Chagas de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) (E-26/201.330/2016), edital Arbovírus, and PhD scholarship from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil for C. R.
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ABSTRACT

Dengue, Zika and Chikungunya are emerging arboviruses and important causes of acute febrile disease in tropical areas. Although dengue does not represent a new condition, a geographic expansion over time has occurred with the appearance of severe neurological complications. Neglect has allowed the propagation of the vector (Aedes spp), which is also responsible for the transmission of other infections such as Zika and Chikungunya throughout the world. The increased number of infected individuals has contributed to the rise of neurological manifestations including encephalitis, myelitis, meningitis, Guillain-Barré syndrome and congenital malformations such as microcephaly. In this narrative review, we characterize the impact of the geographic expansion of the vector on the appearance of neurological complications, and highlight the lack of highly accurate laboratory tests for nervous system infections. This represents a challenge for public health in the world, considering the high number of travelers and people living in endemic areas.

RESUMO

Dengue, Zika e Chikungunya são arbovírus emergentes e importante causa de doença febril aguda em áreas tropicais. Embora a dengue não represente uma doença nova, houve uma expansão geográfica ao longo do tempo, com o aparecimento de complicações neurológicas graves. A negligência desta situação permitiu a propagação do vetor (Aedes spp) em todo o mundo, que também é responsável pela transmissão de outras infecções pelos vírus Zika e Chikungunya. O grande número de casos infectados contribui para o aumento de manifestações neurológicas incluindo encefalite, mielite, meningite, síndrome de Guillain-Barré e má formações congênitas, como microcefalia. Nesta revisão narrativa, destaca-se o impacto da expansão geográfica do vetor no aparecimento de complicações neurológicas e a falta de testes laboratoriais de elevada acurácia para o diagnóstico da infecção neurológica. Estes aspectos representam desafio para a saúde pública mundial, considerando o grande número de indivíduos que moram ou viajam para áreas endêmicas.

Zika virus infection - Dengue - Chikungunya fever - Neurology
infecção pelo Zika virus - Dengue - febre de Chikungunya - Neurologia

Support:

Fundação Carlos Chagas de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) (E-26/201.330/2016), edital Arbovírus, and PhD scholarship from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil for C. R.




Publication History

Received: 22 September 2016

Accepted: 10 October 2016

Article published online:
05 September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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