Subscribe to RSS
![](/products/assets/desktop/img/oa-logo.png)
DOI: 10.1590/0004-282X20170015
Cutaneous allodynia is more frequent in chronic migraine, and its presence and severity seems to be more associated with the duration of the disease
A alodinia cutânea é mais frequente na migrânea crçnica, mas sua presença e gravidade parecem estar associadas com a duração da doença![](https://www.thieme-connect.de/media/10.1055-s-00054595/201703/lookinside/thumbnails/10-1590-0004-282x20170015_20170015-1.jpg)
ABSTRACT
Objective
To evaluate cutaneous allodynia among patients with chronic and episodic migraine in a tertiary headache clinic.
Methods
80 subjects with episodic migraine and 80 with chronic migraine were assessed in a tertiary hospital. The 12-item Allodynia Symptom Checklist/Brazil questionnaire was applied to classify subjects according to the presence and severity of cutaneous allodynia.
Results
Cutaneous allodynia was identified in 81.3% of the episodic migraine group and 92.5% of the chronic migraine group (p = 0.03). No increased association could be attributed to chronic migraine when adjusted by years with disease (PR = 1.12; 95%CI = 0.99 to 1.27; p = 0.06). The groups also did not differ in the severity of allodynia, and severe presentation was the most frequent.
Discussion
Both groups seemed to be similarly affected in the cephalic and extracephalic regions, with the same severity.
Conclusion
Cutaneous allodynia is more frequent in chronic migraine, and its presence and severity seems to be more associated with the duration of the disease.
RESUMO
Objetivo
Avaliar a característica da alodinia cutânea em indivíduos com migrânea crçnica e episódica em um hospital terciário.
Métodos
80 sujeitos com migrânea episódica e 80 com migrânea crçnica de um hospital terciário foram avaliados. O questionário 12-item Allodynia Symptom Checklist/Brasil foi aplicado e classificou os sujeitos quanto a presença e severidade da alodinia cutânea.
Resultados
A alodinia cutânea esteve presente em 81,3% dos migranosos episódicos e 92,5% nos crçnicos (p = 0.03). Nenhuma associação pode ser atribuída a migrânea ao ser ajustada pela variável anos com doença (PR = 1.12; 95%IC = 0.99 para 1.27; p = 0.06). Os grupos não diferiram em relação à severidade da alodinia e a classificação severa foi a mais frequente.
Discussão
Ambos os grupos pareceram ser igualmente afetados nas regiões cefálicas e extracefálicas com a mesma severidade.
Conclusão
A alodinia cutânea é mais frequente na migrânea crçnica, mas a presença e severidade parece estar mais associada com a duração da doença.
Support:
São Paulo Research Foundation (FAPESP).
Publication History
Received: 02 May 2016
Accepted: 21 November 2016
Article published online:
05 September 2023
© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Thieme Revinter Publicações Ltda.
Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil
-
References
- 1 Robbins MS, Lipton RB. The epidemiology of primary headache disorders. Semin Neurol. 2010;30(2):107-19. https://doi.org/10.1055/s-0030-1249220
- 2 Carod-Artal FJ, Irimia P, Ezpeleta D. [Chronic migraine: definition, epidemiology, risk factors and treatment]. Rev Neurol. 2012;54(10):629-37. Spanish.
- 3 Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629-808. https://doi.org/10.1177/0333102413485658
- 4 Bigal ME, Ashina S, Burstein R, Reed ML, Buse D, Serrano D et al. Prevalence and characteristics of allodynia in headache sufferers: a population study. Neurology. 2008;70(17):1525-33. https://doi.org/10.1212/01.wnl.0000310645.31020.b1
- 5 Kalita J, Yadav RK, Misra UK. A comparison of migraine patients with and without allodynia symptoms. Clin J Pain. 2009;25(8):696-8. https://doi.org/10.1097/AJP.0b013e3181b12dd3
- 6 Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR et al. Allodynia in migraine: association with comorbid pain conditions. Headache. 2008;49(9):1333-44. https://doi.org/10.1111/j.1526-4610.2009.01521.x
- 7 Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML et al. Cutaneous allodynia in the migraine population. Ann Neurol. 2008;63(2):148-58. https://doi.org/10.1002/ana.21211
- 8 Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH. Bajwa. An association between migraine and cutaneous allodynia. Ann Neurol. 2000;47(5):614-24. https://doi.org/10.1002/1531-8249(200005)47:5<614::AID-ANA9>3.0.CO;2-N
- 9 Jakubowski M, Silberstein S, Ashkenazi A, Burstein R. Can allodynic migraine patients be identified interictally using a questionnaire? Neurology. 2005;65(9):1419-22. https://doi.org/10.1212/01.wnl.0000183358.53939.38
- 10 Ashkenazi A, Silberstein S, Jakubowski M, Burstein R. Improved identification of allodynic migraine patients using a questionnaire. Cephalalgia. 2007;27(4):325-9. https://doi.org/10.1111/j.1468-2982.2007.01291.x
- 11 Burstein R, Collins B, Jakubowski M. Defeating migraine pain with triptans: a race against the development of cutaneous allodynia. Ann Neurol. 2004;55(1):19-26. https://doi.org/10.1002/ana.10786
- 12 Misra UK, Kalita J, Bhoi SK. Allodynia in migraine: clinical observation and role of prophylactic therapy. Clin J Pain. 2013;29(7):577-82. https://doi.org/10.1097/AJP.0b013e31826b130f
- 13 Schwedt TJ, Krauss MJ, Frey K, Gereau RW 4th. Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks. Cephalalgia. 2010;31(1):6-12. https://doi.org/10.1177/0333102410365108
- 14 Olesen J, Bousser MG, Diener HC, Dodick D, First M, Goadsby PJ et al. New appendix criteria open for a broader concept of chronic migraine. Cephalalgia. 2006;26(6):742-6. https://doi.org/10.1111/j.1468-2982.2006.01172.x
- 15 Florencio LL, Chaves TC, Branisso LB, Gonçalves MC, Dach F, Speciali JG et al. 12 item allodynia symptom cheklist/Brasil: cross-cultural adaptation, internal consistency and reproducibility. Arq Neuropsiquiatr. 2012;70(11):852-6. https://doi.org/10.1590/S0004-282X2012001100006
- 16 Koenker R, Hallock KF. Quantile regression. Cambridge: Cambridge University Press; 2005.
- 17 Aguggia M. Allodynia and migraine. Neurol Sci. 2012;33(Suppl 1):S9-11. https://doi.org/10.1007/s10072-012-1034-9
- 18 Güven H, Çilliler AE, Çomoğlu SS. Cutaneous allodynia in patients with episodic migraine. Neurol Sci. 2013;34(8):1397-402. https://doi.org/10.1007/s10072-012-1249-9
- 19 Louter MA, Bosker JE, Oosterhout WP, Zwet EW, Zitman FG, Ferrari MD et al. Cutaneous allodynia as a predictor of migraine chronification. Brain. 2013;136(11):3489-96. https://doi.org/10.1093/brain/awt251
- 20 Kitaj MB, Klink M. Pain thresholds in daily transformed migraine versus episodic migraine headache patients. Headache. 2005;45(8):992-8. https://doi.org/10.1111/j.1526-4610.2005.05179.x
- 21 Cooke L, Eliasziw M, Becker WJ. Cutaneous allodynia in transformed migraine patients. Headache. 2007;47(4):531-9. https://doi.org/10.1111/j.1526-4610.2006.00717.x
- 22 Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R et al. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010;68(1):81-91. https://doi.org/10.1002/ana.21994