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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2017; 75(04): 216-220
DOI: 10.1590/0004-282X20170024
ARTICLE

Different outcomes of phonemic verbal fluency in Parkinson’s disease patients with subthalamic nucleus deep brain stimulation

Diferentes desfechos na tarefa de fluência verbal fonêmica em pacientes com doença de Parkinson submetidos à estimulação cerebral profunda
Aline Juliane Romann
1   Universidade Federal do Rio Grande do Sul, Programa de Pós Graduação em Medicina: Ciências Médicas, Porto Alegre RS, Brasil;
,
Bárbara Costa Beber
1   Universidade Federal do Rio Grande do Sul, Programa de Pós Graduação em Medicina: Ciências Médicas, Porto Alegre RS, Brasil;
2   Faculdade Nossa Senhora de Fátima, Faculdade de Fonoaudiologia, Caxias do Sul RS, Brasil;
,
Maira Rozenfeld Olchik
1   Universidade Federal do Rio Grande do Sul, Programa de Pós Graduação em Medicina: Ciências Médicas, Porto Alegre RS, Brasil;
3   Universidade Federal do Rio Grande do Sul, Faculdade de Odontologia, Porto Alegre RS, Brasil;
,
Carlos R M. Rieder
1   Universidade Federal do Rio Grande do Sul, Programa de Pós Graduação em Medicina: Ciências Médicas, Porto Alegre RS, Brasil;
4   Hospital de Clínicas de Porto Alegre, Serviço de Neurologia, Porto Alegre RS, Brasil;
5   Universidade Federal Ciências da Saúde, Porto Alegre RS, Brasil.
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ABSTRACT

Subthalamic nucleus deep brain stimulation (STN-DBS) is a surgical technique to treat motor symptoms in patients with Parkinson’s disease (PD). Studies have shown that STN-DBS may cause a decline in verbal fluency performance. We aimed to verify the effects of STN-DBS on the performance of phonemic verbal fluency in Brazilian PD patients. Sixteen participants were evaluated on the Unified Parkinson’s Disease Rating Scale - Part III and for phonemic fluency (“FAS” version) in the conditions of on- and off-stimulation. We identified two different patterns of phonemic verbal fluency outcomes. The results indicate that there may be no expected pattern of effect of bilateral STN-DBS in the phonemic fluency, and patients may present with different outcomes for some reason not well understood.

RESUMO

A estimulação cerebral profunda do núcleo subtalâmico (ECP-NST) é uma técnica cirúrgica para tratar sintomas motores na doença de Parkinson (DP). Estudos têm mostrado que ECP-NST pode causar um declínio no desempenho de fluência verbal. O objetivo do estudo foi verificar os efeitos da ECP-NST sobre o desempenho da fluência verbal fonêmica em indivíduos brasileiros com DP. Dezesseis participantes foram avaliados quanto ao desempenho motor (UPDRS-III) e à fluência verbal fonêmica (versão “FAS”) nas condições de estimulação ligada e desligada. Identificamos dois padrões diferentes de resultados de fluência verbal fonêmica. Os resultados indicam que pode não haver um padrão esperado de efeito de ECP-NST bilateral na fluência fonêmica, e os pacientes podem apresentar desfechos diferentes de acordo com alguma razão não bem compreendida.

Parkinson disease - deep brain stimulation - language - cognition
doença de Parkinson - estimulação encefálica profunda - linguagem - cognição

Support:

Fundo de Incentivo à Pesquisa e Eventos (FIPE), Hospital de Clínicas de Porto Alegre (HCPA).




Publikationsverlauf

Eingereicht: 08. November 2016

Angenommen: 06. Januar 2017

Artikel online veröffentlicht:
05. September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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