The use of a formula-based ketogenic diet in children with refractory epilepsy

Letícia Pereira de Brito Sampaio; Cristina Takakura; Maria Luiza Giraldes de Manreza

doi:10.1590/0004-282X20170028

Arquivos de Neuro-Psiquiatria, Table of Contents

CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2017; 75(04): 234-237
DOI: 10.1590/0004-282X20170028

ARTICLE

The use of a formula-based ketogenic diet in children with refractory epilepsy

O uso da dieta cetogênica a base de fórmula em crianças com epilepsia refratária

Authors

Letícia Pereira de Brito Sampaio

¹Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Instituto da Criança, Departamento de Neuropediatria, São Paulo SP, Brasil;
Cristina Takakura

²Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Instituto da Criança, Departamento de Nutrição, São Paulo SP, Brasil.
Maria Luiza Giraldes de Manreza

¹Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Instituto da Criança, Departamento de Neuropediatria, São Paulo SP, Brasil;

Abstract

ABSTRACT

The ketogenic diet (KD) is a nonpharmacologic treatment that has been used for refractory epilepsy since 1921. The KD is a high-fat, low-carbohydrate, and restricted protein diet, which is calculated and weighed for each individual patient. Introducing and maintaining the diet for a long time remains a challenge. In this study, we evaluated the acceptability, tolerance, and efficacy of a formula-based KD in 10 children with refractory epilepsy. The ketogenic formula tested herein caused only mild KD-related adverse events and adequate adherence. Moreover, 60% of patients had more than 50% seizure frequency reduction and 10% were seizure-free.

RESUMO

A dieta cetogênica (DC) é um tratamento não farmacológico utilizado para epilepsia refratária desde 1921. A DC possui um alto teor de gordura, sendo restrita em carboidratos e adequada em proteínas, calculada e pesada para cada paciente. A introdução e manutenção da DC por um tempo prolongado permanece um desafio. Neste estudo foi avaliada a aceitação, tolerância e eficácia da DC baseada em fórmula em 10 crianças com epilepsia refratária. A DC apresentou adequada aderência e efeitos adversos leves. Além disso, 60% dos pacientes apresentaram mais de 50 % de redução frequência das crises e 10% ficaram livres de crises.

ketogenic diet - epilepsy - diet therapy

dieta cetogênica - epilepsia - dietoterapia

Full Text

References

References
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