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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2017; 75(06): 381-386
DOI: 10.1590/0004-282X20170066
TRICK OF THE TRADE

Discordant clinical outcomes of congenital Zika virus infection in twin pregnancies

Evolução clínica discordante da infecção congénita do vírus Zika em gestação gemelar
Vanessa van der Linden
1   Hospital Barão de Lucena, Recife PE, Brasil;
2   Associação de Assistência à Criança Deficiente (AACD), Recife PE, Brasil;
,
Hélio van der Linden Junior
3   Centro de Reabilitação Dr. Henrique Santillo, Goiania GO, Brasil;
,
Mariana de Carvalho Leal
4   Universidade Federal de Pernambuco, Recife PE, Brasil;
5   Hospital Agamenon Magalhães, Recife PE, Brasil;
,
Epitacio Leite Rolim Filho
2   Associação de Assistência à Criança Deficiente (AACD), Recife PE, Brasil;
4   Universidade Federal de Pernambuco, Recife PE, Brasil;
,
Ana van der Linden
6   Instituto de Medicina Integral Professor Fernando Figueira, Recife PE, Brasil;
,
Maria de Fátima Viana Vasco Aragão
7   Centro Diagnóstico Multimagem, Recife PE, Brasil;
8   Universidade Mauricio de Nassau, Recife PE, Brasil;
,
Alessandra Mertens Brainer-Lima
9   Universidade de Pernambuco, Recife PE, Brasil;
,
Danielle Di Cavalcanti Sousa Cruz
6   Instituto de Medicina Integral Professor Fernando Figueira, Recife PE, Brasil;
,
Liana O. Ventura
10   Fundação Altino Ventura, Recife PE, Brasil;
11   Hospital de Olhos de Pernambuco (HOPE), Recife PE, Brasil;
,
Telma Lúcia Tabosa Florêncio
12   UniVision, Recife PE, Brasil;
,
Marli Tenório Cordeiro
13   Centro de Pesquisas Aggeu Magalhães-Fiocruz, Recife PE, Brasil;
,
Silvio da Silva Caudas Neto
4   Universidade Federal de Pernambuco, Recife PE, Brasil;
,
Regina Coeli Ramos
14   Hospital Universitário Oswaldo Cruz, Recife PE, Brasil;
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ABSTRACT

Congenital Zika syndrome is an emergent cause of a congenital infectious disorder, resulting in severe damage to the central nervous system and microcephaly. Despite advances in understanding the pathophysiology of the disease, we still do not know all the mechanisms enrolled in the vertical transmission of the virus. As has already been reported in other types of congenital infectious disorders in dizygotic twin pregnancies, it is possible that the virus affects only one of the fetuses. In this article, we report on two cases of twin pregnancies exposed to the Zika virus, but with only one of the fetuses affected with microcephaly and brain damage. This indicates the urgent need for more studies regarding the pathophysiology of viral infection and the mechanisms involved in the natural protection against the virus.

RESUMO

A síndrome congênita do Zika vírus é uma causa de infecção congênita emergente, resultando em graves danos ao sistema nervoso central e microcefalia. Apesar dos avanços na compreensão da fisiopatologia da doença, ainda não conhecemos todo o mecanismo envolvido na transmissão vertical do vírus. Como já foi relatado em outros tipos de infecções congênitas em gestações gemelares dizigóticas, é possível que apenas um dos fetos seja afetado pelo vírus. Este artigo descreve 2 casos de gestações gemelares expostas ao vírus Zika, onde apenas um dos fetos foi afetado, com microcefalia associado a graves danos no sistema nervoso central. Isso indica a necessidade urgente de mais estudos sobre a fisiopatologia da infecção viral e os mecanismo envolvidos na proteção natural contra o vírus.

Zika virus - Zika virus infection - twins, dizygotic
Zika virus - infecção pelo Zika virus - gêmeos dizigóticos


Publication History

Received: 05 February 2017

Accepted: 06 March 2017

Article published online:
05 September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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