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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2017; 75(07): 451-456
DOI: 10.1590/0004-282X20170070
ARTICLES

Late onset multiple sclerosis: concerns in aging patients

Esclerose múltipla de início tardio: atenção a uma população que envelhece
Claudia Beatriz de Campos Lotti
1   Universidade Federal de São Paulo, Departamento de Neurologia, São Paulo SP, Brasil;
,
Acary Souza Bulle Oliveira
1   Universidade Federal de São Paulo, Departamento de Neurologia, São Paulo SP, Brasil;
,
Denis Bernardi Bichuetti
1   Universidade Federal de São Paulo, Departamento de Neurologia, São Paulo SP, Brasil;
,
Isac de Castro
2   Universidade de São Paulo, Faculdade de Medicina, Disciplina de Nefrologia, São Paulo SP, Brasil.
,
Enedina Maria Lobato Oliveira
1   Universidade Federal de São Paulo, Departamento de Neurologia, São Paulo SP, Brasil;
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ABSTRACT

Late onset multiple sclerosis (LOMS) is when the first symptom starts after 50 years of age, representing 4.5% of multiple sclerosis (MS) patients. This study describes the clinical characteristics of patients with LOMS followed at a specialized MS center in São Paulo. Data was obtained from medical records of 742 patients with MS. The LOMS frequency was 4.18%, median age at onset was 54 years and the predominant disease course was primary progressive (64.3%). The patients reached the disability landmarks of EDSS grades 3.0, 6.0 and 7.0 in the following proportion and time: EDSS 3.0: 77.42% of patients in 3.7 years; EDSS 6.0: 58.06% in 5.1 years and EDSS 7.0: 32.26% in 5.7 years. The comparative analysis with a matched control group of patients with early onset MS showed that late onset, associated with a progressive course, were predictors of reaching EDSS 3.0 and 6.0 in a shorter time.

RESUMO

Esclerose múltipla de inicio tardio (EMIT) caracteriza-se pelo início de sintomas aos 50 ou mais anos de idade, representando 4,5% dos pacientes com esclerose múltipla (EM). Este estudo descreve as características clínicas de pacientes com EMIT acompanhados num centro de EM em São Paulo. Dados foram obtidos através de análise de prontuário de 742 pacientes com EM. A frequência de EMIT foi de 4,18%, a mediana da idade de início foi de 54 anos e a forma clínica predominante a primariamente progressiva (64,3%). Os pacientes atingiram os marcos de incapacidade EDSS 3, 6 e 7 nas respectivas proporções e tempo: EDSS 3.0, 77,42% de pacientes em 3.7 anos; EDSS 6.0, 58,06% em 5.1 anos e EDSS 7.0, 32,26% em 5.7 anos. A análise comparativa a um grupo controle de jovens com EM, mostrou que o início tardio associado a forma primariamente progressiva foram preditores para atingir EDSS 3 e 6 num período menor.

aging - epidemiology - multiple sclerosis - disease progression
envelhecimento - epidemiologia - esclerose múltipla - progressão da doença


Publication History

Received: 28 December 2016

Accepted: 20 March 2017

Article published online:
05 September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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