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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2017; 75(07): 457-463
DOI: 10.1590/0004-282X20170075
CLINICAL SCALES, CRITERIA AND TOOLS

Quantitative Myasthenia Gravis Score: a Brazilian multicenter study for translation, cultural adaptation and validation

Teste Quantitativo para Miastenia Gravis: estudo multicêntrico brasileiro para tradução, adaptação cultural e validação
Ezequiel Fernandes Oliveira
1   Universidade Nove de Julho, Programa de Pós-Graduação Doutorado em Ciências da Reabilitação, São Paulo SP, Brasil;
,
Berenice Cataldo Oliveira Valério
2   Faculdade de Ciências Médicas da Santa Casa de São Paulo, Departamento de Clínica Médica, Disciplina de Neurologia, São Paulo SP, Brasil;
,
Valéria Cavalcante
3   Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Divisão de Distúrbios Neuromusculares, São Paulo SP, Brasil;
,
Jessica Julioti Urbano
1   Universidade Nove de Julho, Programa de Pós-Graduação Doutorado em Ciências da Reabilitação, São Paulo SP, Brasil;
,
Anderson Soares Silva
1   Universidade Nove de Julho, Programa de Pós-Graduação Doutorado em Ciências da Reabilitação, São Paulo SP, Brasil;
,
Melissa Nunes Polaro
2   Faculdade de Ciências Médicas da Santa Casa de São Paulo, Departamento de Clínica Médica, Disciplina de Neurologia, São Paulo SP, Brasil;
,
Sergio Roberto Nacif
4   Hospital Servidor Publico Estadual, Programa de Pós-Graduação Doutorado em Ciências da Saúde, São Paulo SP, Brasil;
,
Claudia Santos Oliveira
1   Universidade Nove de Julho, Programa de Pós-Graduação Doutorado em Ciências da Reabilitação, São Paulo SP, Brasil;
,
Maria Bernadete Dutra Resende
5   Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Neurologia Clínica, São Paulo SP, Brasil.
,
Acary Souza Bulle Oliveira
3   Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Divisão de Distúrbios Neuromusculares, São Paulo SP, Brasil;
,
Luis Vicente Franco Oliveira
1   Universidade Nove de Julho, Programa de Pós-Graduação Doutorado em Ciências da Reabilitação, São Paulo SP, Brasil;
› Author AffiliationsSupport: The Sleep Laboratory receives funding from the Nove de Julho University (Brazil) and research projects approved by the Brazilian fostering agencies Fundação de Amparo a Pesquisa do Estado de São Paulo (local acronym FAPESP; protocol no. 2003/01810-4) and LVFO receives Research Productivity modality PQIB grants by Conselho Nacional de Desenvolvimento Científico e Tecnológico (local acronym CNPq; process no. 313053/2014-6). EFO receives grants of Fundação de Amparo a Pesquisa do Estado de São Paulo (local acronym FAPESP; protocol no. 2015/11738-6).
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ABSTRACT

Objective

To perform the translation, cross-cultural adaptation and validation of the Quantitative Myasthenia Gravis Score (QMGS) to Brazilian Portuguese in accordance with international ethical standards.

Methods

The following steps were taken: (1) implementation of the translation protocol and transcultural adaptation, (2) validation of the adapted content, and (3) assessment of reliability. To check intra- and inter-observer reproducibility, each patient underwent two interviews with interviewer-A and one with B. The QMGS was compared to the Myasthenia Gravis Composite Scale and Myasthenia-specific Quality of Life Questionnaire.

Results

Our study group consisted of 30 patients, with a mean age of 47.6±11.4 years and a mean duration of illness of 11.33±8.49 years. Correlation between the QMGS and MGC was very strong (r = 0.928; p < 0.001) and substantial between the QMGS and MG-QOL 15 (r = 0.737; p < 0.001).

Conclusion

The Brazilian Portuguese translation, and validation of the QMGS was successfully performed.

RESUMO

Objetivo

O objetivo foi realizar a tradução e validação do teste quantitativo para Miastenia Gravis (QMGS) para Português do Brasil, de acordo com as diretrizes internacionais.

Métodos

Foram realizadas as etapas de implementação do protocolo de tradução e adaptação transcultural, validação do conteúdo adaptado e avaliação da confiabilidade. Para verificar a reprodutibilidade intra e inter-observador cada paciente foi submetido a duas entrevistas por um entrevistador-A e um B. O QMGS foi comparado ao MG Composite Scale e Myasthenia-specific Quality of Life Questionnaire.

Resultados

O estudo inclui 30 pacientes, com a média de idade de 47,6±11,4 anos e tempo médio de doença de 11,33±8,49 anos. A correlação entre QMGS e MGC apresentou-se muito forte (r = 0,928; p < 0,001) e substancial entre QMGS e MG-QOL 15 (r = 0,737; p < 0,001).

Conclusão

A tradução, e validação do QMGS para o português do Brasil foi realizada com sucesso.

myasthenia gravis - cross-cultural comparison - translations - validation studies
miastenia gravis - comparação transcultural - traduções - estudos de validação

Support:

The Sleep Laboratory receives funding from the Nove de Julho University (Brazil) and research projects approved by the Brazilian fostering agencies Fundação de Amparo a Pesquisa do Estado de São Paulo (local acronym FAPESP; protocol no. 2003/01810-4) and LVFO receives Research Productivity modality PQIB grants by Conselho Nacional de Desenvolvimento Científico e Tecnológico (local acronym CNPq; process no. 313053/2014-6). EFO receives grants of Fundação de Amparo a Pesquisa do Estado de São Paulo (local acronym FAPESP; protocol no. 2015/11738-6).




Publication History

Received: 03 October 2016

Accepted: 30 March 2017

Article published online:
05 September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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