Quality of life in Parkinson’s disease patients: progression markers of mild to moderate stages

Raissa Carla Moreira; Marise Bueno Zonta; Ana Paula Serra de Araújo; Vera Lúcia Israel; Hélio A. G. Teive

doi:10.1590/0004-282X20170091

Arquivos de Neuro-Psiquiatria, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2017; 75(08): 497-502
DOI: 10.1590/0004-282X20170091

ARTICLES

Quality of life in Parkinson’s disease patients: progression markers of mild to moderate stages

Qualidade de vida de indivíduos com doença de Parkinson: marcadores da progressão da fase leve para moderada

Raissa Carla Moreira

¹Universidade Federal do Paraná, Curitiba PR, Brasil;

,

Marise Bueno Zonta

²Universidade Federal do Paraná, Hospital de Clínicas, Departamento de Reabilitação, Curitiba PR, Brasil;

,

Ana Paula Serra de Araújo

³Secretaria Municipal de Saúde, Prefeitura Municipal de Guarapuava, Guarapuava PR, Brasil;

,

Vera Lúcia Israel

⁴Universidade Federal do Paraná, Departamento de Fisioterapia, Curitiba PR, Brasil;

,

Hélio A. G. Teive

⁵Universidade Federal do Paraná, Departamento de Medicina, Curitiba PR, Brasil.

› Institutsangaben

Abstract

ABSTRACT

Objective

To investigate which factors are associated with the quality of life decline in Parkinson’s disease patients from mild to moderate stages.

Methods

The Unified Parkinson’s Disease Rating Scale and Parkinson’s Disease Questionnaire-39 were used to evaluate clinical/functional data and the quality of life.

Results

The markers of clinical/functional worsening were drooling (p < 0.004), need for assistance with hygiene (p = 0.02), greater freezing frequency (p = 0.042), bradykinesia (p = 0.031), greater intensity of the resting tremor (p = 0.035) and “pill rolling” (p = 0.001). The decline in quality of life was related to stigma (p = 0.043), greater impairment in cognition (p = 0.002), mobility (p = 0.013) and for daily living activities (p = 0.05), and was considered more significant in men, married, older individuals, and those with a longer time of disease.

Conclusions

The quality of life worsening markers at the moderate stage were related to stigma, worsening of cognition, and to greater impairment in mobility and daily living activities.

RESUMO

Objetivo

Verificar os fatores relacionados ao declínio clínico/funcional e de Qualidade de Vida de indivíduos com Doença de Parkinson, da fase leve para moderada.

Métodos

Foram utilizadas as escalas Unified Parkinson’s Disease Rating Scale and Parkinson’s Disease Questionnaire-39 (UPDRS e PDQ-39) para avaliação clínico/funcional e de qualidade de vida

Resultados

Os marcadores de piora clínico/funcional na fase moderada foram: sialorréia (p < 0,004), necessidade de ajuda para higiene (p = 0,02), maior frequência do “freezing” (p = 0,042), bradicinesia (p = 0,031) e maior intensidade do tremor de repouso (p = 0,035) e bater dos dedos (p = 0,001). O declínio da qualidade de vida esteve relacionado ao estigma (p = 0,043), ao maior comprometimento da cognição (p = 0,002), da mobilidade (p = 0,013) e da independência para realizar as atividade de vida diária (AVD’s) (p = 0,05), sendo mais importante nos homens, nos casados, nos indivíduos com maior idade e naqueles com maior tempo de evolução da doença.

Conclusão

Os marcadores de piora da qualidade de vida na fase moderada estiveram relacionados ao estigma, à piora da cognição, ao maior comprometimento para mobilidade e AVD’s.

Parkinson disease - quality of life - surveys and questionnaires

doença de Parkinson - qualidade de vida - inquéritos e questionários

Volltext

Referenzen

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