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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2017; 75(08): 539-545
DOI: 10.1590/0004-282X20170109
ARTICLES

Bereitschaftspotential preceding eyelid blinks in Parkinson’s disease

Potencial de Bereitschafts precedendo o piscamento ocular na doença de Parkinson
Isabella Araújo Mota
1   Hospital Universitário Lauro Wanderley, Ambulatório de Neurologia, João Pessoa PB, Brasil;
,
Maria das Graças Coriolano
2   Universidade Federal de Pernambuco, Departamento de Anatomia, Recife PE, Brasil;
,
Otávio Gomes Lins
3   Universidade Federal de Pernambuco, Departamento de Neuropsiquiatria, Recife PE, Brasil.
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ABSTRACT

The Bereitschaftspotential (BP) is a negative wave observed in EEG retrograde averaging, preceding a motor act. The objective was to study the BP preceding voluntary eyelid blinks in Parkinson’s disease (PD) patients during off and on phases of levodopa.

Methods

Ten PD patients in stages 1 and 2 of the Hoehn & Yahr classification were compared to 18 healthy controls. Artifact-free EEG segments of two seconds preceding the onset of the blink potential were averaged and analyzed, and the statistical significance of the measured amplitudes were evaluated by analysis of variance models.

Results

The presence of a BP in the PD patients was demonstrated. The mean amplitudes at 0 ms were respectively 0.6 μV and 3.3 μV for the BP patients and the normal controls, respectively.

Conclusions

The BP amplitudes were significantly smaller in PD patients than normal participants. The amplitudes of the BP were not modified by levodopa.

RESUMO

O Potencial de Bereitschafts (PB) é uma onda negativa observada retrogradamente no EEG precedendo um ato motor.

Objetivo

Estudar o PB precedendo o piscamento palpebral voluntário em pacientes com doença de Parkinson (DP) durante as fases off e on da levodopa. Foram comparados dez pacientes com DP nos estágios 1 e 2 de Hoehn & Yahr com 18 controles saudáveis. Os segmentos de EEG livres de artefatos 2 segundos antes do início do potencial foram calculados e analisados e a significância estatística das amplitudes foi medida por modelos de análise de variância.

Resultados

A presença de PB nos pacientes com DP foi demonstrada. As amplitudes médias a 0 ms foram respectivamente 0,6 μV e 3,3 μV para os pacientes com DP e controles respectivamente.

Conclusões

As amplitudes do PB foram significativamente menores nos pacientes com DP do que controles. As amplitudes do PB não foram modificadas pela levodopa.

contingent negative variation - Parkinson disease - levodopa
variação contigente negativa - doença de Parkinson - levodopa


Publication History

Received: 10 February 2017

Accepted: 04 May 2017

Article published online:
05 September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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