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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2017; 75(10): 736-747
DOI: 10.1590/0004-282X20170132
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Neurological complications of solid organ transplantation

Complicações neurológicas no transplante de órgãos sólidos
José Luiz Pedroso
1   Universidade Federal de São Paulo, Divisão de Neurologia Geral, Departamento de Neurologia, São Paulo SP, Brasil;
,
Lívia Almeida Dutra
1   Universidade Federal de São Paulo, Divisão de Neurologia Geral, Departamento de Neurologia, São Paulo SP, Brasil;
,
Pedro Braga-Neto
2   Universidade Estadual do Ceará, Centro de Ciências da Saúde, Fortaleza CE, Brasil;
3   Universidade Federal do Ceará, Faculdade de Medicina, Departamento de Clínica Médica, Fortaleza, CE, Brasil;
,
Agessandro Abrahao
1   Universidade Federal de São Paulo, Divisão de Neurologia Geral, Departamento de Neurologia, São Paulo SP, Brasil;
,
João Brainer Clares de Andrade
1   Universidade Federal de São Paulo, Divisão de Neurologia Geral, Departamento de Neurologia, São Paulo SP, Brasil;
,
Gabriel Lopes da Silva
1   Universidade Federal de São Paulo, Divisão de Neurologia Geral, Departamento de Neurologia, São Paulo SP, Brasil;
,
Laila Almeida Viana
4   Universidade Federal de São Paulo, Departamento de Nefrologia, São Paulo SP, Brasil.
,
José Osmar Medina Pestana
4   Universidade Federal de São Paulo, Departamento de Nefrologia, São Paulo SP, Brasil.
,
Orlando G. Barsottini
1   Universidade Federal de São Paulo, Divisão de Neurologia Geral, Departamento de Neurologia, São Paulo SP, Brasil;
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ABSTRACT

Solid organ transplantation is a significant development in the treatment of chronic kidney, liver, heart and lung diseases. This therapeutic approach has increased patient survival and improved quality of life. New surgical techniques and immunosuppressive drugs have been developed to achieve better outcomes. However, the variety of neurological complications following solid organ transplantation is broad and carries prognostic significance. Patients may have involvement of the central or peripheral nervous system due to multiple causes that can vary depending on time of onset after the surgical procedure, the transplanted organ, and the intensity and type of immunosuppressive therapy. Neurological manifestations following solid organ transplantation pose a diagnostic challenge to medical specialists despite extensive investigation. This review aimed to provide a practical approach to help neurologists and clinicians assess and manage solid organ transplant patients presenting with acute or chronic neurological manifestations.

RESUMO

O transplante de órgãos sólidos é um importante avanço no tratamento de doenças crçnicas renal, hepática e cardíaca. Esta terapia tem aumentado a sobrevida e melhorado a qualidade de vida dos pacientes. Novas técnicas cirúrgicas e imunossupressores tem sido desenvolvidos para alcançar melhores desfechos. Entretanto, a variedade de complicações neurológicas que acompanham o transplante de órgãos sólidos é ampla, e carrega significado prognóstico. Pacientes podem ter acometimento do sistema nervoso central ou periférico devido a múltiplas causas que podem variar conforme o tempo após a realização da cirurgia, órgão transplantado e grau e tipo de terapia de imunossupressão. Manifestações neurológicas após o transplante de órgãos sólidos representam um desafio diagnóstico para médicos especialistas apesar de extensa investigação. O objetivo desta revisão é oferecer uma abordagem prática para ajudar neurologistas e clínicos a avaliar e manejar pacientes com transplante de órgãos sólidos que se apresentem com manifestações neurológicas agudas ou crçnicas.

Keywords:

organ transplantation - neurological manifestations - central nervous system - peripheral nervous system

Palavras-chave:

transplante de órgãos - manifestações neurológicas - sistema nervoso central - sistema nervoso periférico


Publication History

Received: 07 July 2017

Accepted: 12 July 2017

Article published online:
04 September 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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