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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2018; 76(02): 100-103
DOI: 10.1590/0004-282X20170196
Article

Traumatic brain injury pharmacological treatment: recommendations

Tratamento farmacológico do traumatismo cranioencefálico: recomendações

Authors

  • Renato Anghinah

    1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Divisão de Neurologia, Serviço de Reabilitação Cognitiva pós-TCE, São Paulo SP Brasil

  • Robson Luís Oliveira de Amorim

    2   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Divisão de Neurocirurgia, Serviço de Emergência, São Paulo SP, Brasil

  • Wellingson Silva Paiva

    2   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Divisão de Neurocirurgia, Serviço de Emergência, São Paulo SP, Brasil

  • Magali Taino Schmidt

    1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Divisão de Neurologia, Serviço de Reabilitação Cognitiva pós-TCE, São Paulo SP Brasil

  • Jéssica Natuline Ianof

    1   Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Divisão de Neurologia, Serviço de Reabilitação Cognitiva pós-TCE, São Paulo SP Brasil
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ABSTRACT

This article presents the recommendations on the pharmacological treatment employed in traumatic brain injury (TBI) at the outpatient clinic of the Cognitive Rehabilitation after TBI Service of the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil. A systematic assessment of the consensus reached in other countries, and of articles on TBI available in the PUBMED and LILACS medical databases, was carried out. We offer recommendations of pharmacological treatments in patients after TBI with different symptoms.

RESUMO

Este artigo apresenta as recomendações sobre o tratamento farmacológico empregado para o traumatismo cranioencefálico (TCE) em pacientes ambulatoriais de Reabilitação Cognitiva pós-TCEno Serviço do HCFMUSP Foi realizada uma avaliação sistemática dos consensos publicados em outros países e dos artigos sobre TCE disponíveis nas bases de periódicos médicos como PUBMED e LILACS. Recomendamos tratamentos farmacológicos em pacientes pós-TCE com diferentes sintomas.

Keywords:

guideline - therapeutics - brain injuries - traumatic

Palavras-chave:

guia - terapêutica - lesões encefálicas traumáticas


Publication History

Received: 20 September 2017

Accepted: 21 November 2017

Article published online:
28 August 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Jang SH. Review of motor recovery in patients with traumatic brain injury. NeuroRehabilitation. 2009;24(4):349-53. https://do.org/10.3233/NRE-2009-0489
  • 2 Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, Kobusingye OC. The impact of traumatic brain injuries: a global perspective. NeuroRehabilitation. 2007;22(5):341-53.
  • 3 Andrade AF, Manreza LA, Giudicissi M. Filho, Miura FK. Normas de atendimento ao paciente com traumatismo crânio-encefálico. Temas Atuais Neurocirur. 1996;2:1-22.
  • 4 Plantier D, Luauté J. Drugs for behavior disorders after traumatic brain injury: systematic review and expert consensus leading to French recommendations for good practice. Ann Phys Rehabil Med. 2016 Feb;59(1):42-57. https://doi.org/10.1016/j.rehab.2015.10.003
  • 5 Willmott C, Ponsford J. Efficacy of methylphenidate in the rehabilitation of attention following traumatic brain injury: a randomised, crossover, double blind, placebo controlled inpatient trial. J Neurol Neurosurg Psychiatry. 2009 May;80(5):552-7. https://doi.org/10.1136/jnnp.2008.159632
  • 6 O’Neill B, Gardani M, Findlay G, Whyte T, Cullen T. Challenging behaviour and sleep cycle disorder following brain injury: a preliminary response to agomelatine treatment. Brain Inj. 2014;28(3):378-81. https://doi.org/10.3109/02699052.2013.865264
  • 7 Kaiser PR, Valko PO, Werth E, Thomann J, Meier J, Stocker R et al. Modafinil ameliorates excessive daytime sleepiness after traumatic brain injury. Neurology. 2010 Nov;75(20):1780-5. https://doi.org/10.1212/WNL.0b013e3181fd62a2
  • 8 Jha A, Weintraub A, Allshouse A, Morey C, Cusick C, Kittelson J et al. A randomized trial of modafinil for the treatment of fatigue and excessive daytime sleepiness in individuals with chronic traumatic brain injury. J Head Trauma Rehabil. 2008 Jan-Feb;23(1):52-63. https://doi.org/10.1097/01.HTR.0000308721.77911.ea
  • 9 Sheng P, Hou L, Wang X, Wang X, Huang C, Yu M et al. Efficacy of modafinil on fatigue and excessive daytime sleepiness associated with neurological disorders: a systematic review and meta-analysis. PLoS One. 2013 Dec;8(12):e81802. https://doi.org/10.1371/journal.pone.0081802
  • 10 Hammond FM1. Bickett AK, Norton JH, Pershad R. Effectiveness of amantadine hydrochloride in the reduction of chronic traumatic brain injury irritability and aggression. J Head Trauma Rehabil. 2014 Sep-Oct;29(5):391-9. https://doiorg/10.1097/01.HTR.0000438116.56228.de
  • 11 Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med. 2012 Mar;366(9):819-26. https://doi.org/10.1056/NEJMoa1102609
  • 12 Khouzam HR, Donnelly NJ. Remission of traumatic brain injury-induced compulsions during venlafaxine treatment. Gen Hosp Psychiatry. 1998 Jan;20(1):62-3. https://doi.org/10.1016/S0163-8343(97)00097-2
  • 13 Dikmen SS, Machamer JE, Winn HR, Anderson GD, Temkin NR. Neuropsychological effects of valproate in traumatic brain injury: a randomized trial. Neurology. 2000 Feb;54(4):895-902. https://doi.org/10.1212/WNL.54.4.895
  • 14 Temkin NR, Dikmen SS, Anderson GD, Wilensky AJ, Holmes MD, Cohen W et al. Valproate therapy for prevention of posttraumatic seizures: a randomized trial. J Neurosurg. 1999 Oct;91(4):593-600. https://doi.org/10.3171/jns.1999.91.4.0593
  • 15 Rapoport MJ, Mitchell RA, McCullagh S, Herrmann N, Chan F, Kiss A et al. A randomized controlled trial of antidepressant continuation for major depression following traumatic brain injury. J Clin Psychiatry. 2010 Sep;71(9):1125-30. https://doi.org/10.4088/JCP.09m05086blu
  • 16 Baños JH, Novack TA, Brunner R, Renfroe S, Lin HY, Meythaler J. Impact of early administration of sertraline on cognitive and behavioral recovery in the first year after moderate to severe traumatic brain injury. J Head Trauma Rehabil. 2010 Sep-Oct;25(5):357-61. https://doi.org/10.1097/HTR.0b013e3181d6c715
  • 17 Novack TA, Baños JH, Brunner R, Renfroe S, Meythaler JM. Impact of early administration of sertraline on depressive symptoms in the first year after traumatic brain injury. J Neurotrauma. 2009 Nov;26(11):1921-8. https://doi.org/10.1089/neu.2009.0895
  • 18 Davidson JR, Connor KM, Hertzberg MA, Weisler RH, Wilson WH, Payne VM. Maintenance therapy with fluoxetine in posttraumatic stress disorder: a placebo-controlled discontinuation study. J Clin Psychopharmacol. 2005 Apr;25(2):166-9. https://doi.org/10.1097/01.jcp.0000155817.21467.6c
  • 19 Whyte J, Vaccaro M, Grieb-Neff P, Hart T, Polansky M, Coslett HB. The effects of bromocriptine on attention deficits after traumatic brain injury: a placebo-controlled pilot study. Am J Phys Med Rehabil. 2008 Feb;87(2):85-99. https://doi.org/10.1097/PHM.0b013e3181619609
  • 20 Lee H, Kim SW, Kim JM, Shin IS, Yang SJ, Yoon JS. Comparing effects of methylphenidate, sertraline and placebo on neuropsychiatric sequelae in patients with traumatic brain injury. Hum Psychopharmacol. 2005 Mar;20(2):97-104. https://doi.org/10.1002/hup.668
  • 21 Whyte J, Vaccaro M, Grieb-Neff P, Hart T, Polansky M, Coslett HB. The effects of bromocriptine on attention deficits after traumatic brain injury: a placebo-controlled pilot study. Am J Phys Med Rehabil. 2008 Feb;87(2):85-99. https://doi.org/10.1097/PHM.0b013e3181619609
  • 22 Silver JM, Koumaras B, Chen M, Mirski D, Potkin SG, Reyes P et al. Effects of rivastigmine on cognitive function in patients with traumatic brain injury. Neurology. 2006 Sep;67(5):748-55. https://doi.org/10.1212/01.wnl.0000234062.98062.e9
  • 23 Tenovuo O. Central acetylcholinesterase inhibitors in the treatment of chronic traumatic brain injury-clinical experience in 111 patients. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jan;29(1):61-7. https://doi.org/10.1016/j.pnpbp.2004.10.006
  • 24 Kim YW, Kim DY, Shin JC, Park CI, Lee JD. The changes of cortical metabolism associated with the clinical response to donepezil therapy in traumatic brain injury. Clin Neuropharmacol. 2009 Mar-Apr;32(2):63-8. https://doi.org/10.1097/WNF.0b013e31816f1bc1
  • 25 Zhang L, Plotkin RC, Wang G, Sandel ME, Lee S. Cholinergic augmentation with donepezil enhances recovery in short-term memory and sustained attention after traumatic brain injury. Arch Phys Med Rehabil. 2004 Jul;85(7):1050-5. https://doi.org/10.1016/j.apmr.2003.10.014