Arquivos de Neuro-Psiquiatria, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2018; 76(03): 145-149
DOI: 10.1590/0004-282X20180003

Article

Can the CERAD neuropsychological battery be used to assess cognitive impairment in Parkinson's disease?

A bateria neuropsicológica do CERAD pode ser usada para avaliação cognitiva em pacientes com doença de Parkinson?

Carlos Henrique Ferreira Camargo

¹Universidade Estadual de Ponta Grossa, Hospital Universitário Regional dos Campos Gerais, Serviço de Neurologia, Ponta Grossa PR, Brasil

,

Augusto Bronzini

¹Universidade Estadual de Ponta Grossa, Hospital Universitário Regional dos Campos Gerais, Serviço de Neurologia, Ponta Grossa PR, Brasil

,

Eduardo de Souza Tolentino

¹Universidade Estadual de Ponta Grossa, Hospital Universitário Regional dos Campos Gerais, Serviço de Neurologia, Ponta Grossa PR, Brasil

,

Camila Medyk

¹Universidade Estadual de Ponta Grossa, Hospital Universitário Regional dos Campos Gerais, Serviço de Neurologia, Ponta Grossa PR, Brasil

,

Gustavo Leopold Schultz-Pereira

¹Universidade Estadual de Ponta Grossa, Hospital Universitário Regional dos Campos Gerais, Serviço de Neurologia, Ponta Grossa PR, Brasil

› Institutsangaben

ABSTRACT

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery was created to assess cognitive impairment in Alzheimer's disease (AD) but it is widely-used for various dementias. The aim of this study was to analyze the efficacy of using the CERAD battery in the assessment of patients with Parkinson's disease. Forty-nine patients with Parkinson's disease were divided into two groups (one with dementia and one without) using the Movement Disorder Society criteria for Parkinson's disease dementia. Cognitive deficits were assessed with the Clinical Dementia Rating Scale as the gold standard, and the CERAD. The ROC curve for the CERAD battery had an area under the curve = 0.989 (95% CI = 0.967 – 1, p<0.0001). Among the CERAD subtests, verbal fluency had the worst accuracy, and word list learning had the best accuracy. Despite the limits of this study, the CERAD battery can be efficient for assessment of cognitive deficits in Parkinson's disease patients.

RESUMO

A Bateria Neuropsicológica do Consortium to Establish a Registry for Alzheimer's Disease (CERAD) foi criada para a avaliação da doença de Alzheimer (DA), mas é usada em várias demências. O objetivo deste estudo foi avaliar a efetividade dessa bateria na avaliação de pacientes com doença de Parkinson (DP). Foram avaliados 49 pacientes com DP sendo aplicadas CDR, como padrão-ouro e CERAD. Os pacientes foram divididos em dois grupos: com e sem demência, a partir dos critérios para DPP pela Movement Disorders Society. A curva ROC para o CERAD resultou em uma AUC=0.989 (95% CI = 0.967 – 1, p<0.0001). Entre os subtestes do CERAD, fluência verbal obteve a pior acurácia, e aprendizado de lista de palavras, a melhor. Apesar das limitações do estudo, a bateria do CERAD pode ser uma ferramenta eficaz na avaliação de déficits cognitivos em pacientes com DP

Keywords

Keywords

Parkinson's disease - dementia - cognition

Palavras-chave

Palavras-chave

doença de Parkinson - demência - cognição

References
1 Lees AJ, Hardy J, Revesz T. Parkinson's disease. Lancet. 2009 Jun;373(9680):2055-66. https://doi.org/10.1016/S0140-6736(09)60492-X
2 Emre M, Aarsland D, Brown R, Burn DJ, Duyckaerts C, Mizuno Y et al. Clinical diagnostic criteria for dementia associated with Parkinson's disease. Mov Disord. 2007 Sep;22(12):1689-707. https://doi.org/10.1002/mds.21507
3 Aarsland D, Bronnick K, Williams-Gray C, Weintraub D, Marder K, Kulisevsky J et al. Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis. Neurology. 2010 Sep;75(1 2):1062-9. https://doi.org/10.1212/WNL.0b013e3181f39d0e
4 Hely MA, Reid WG, Adena MA, Halliday GM, Morris JG. The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov Disord. 2008 Apr;23(6):837-44. https://doi.org/10.1002/mds.21956
5 Janvin CC, Larsen JP, Aarsland D, Hugdahl K. Subtypes of mild cognitive impairment in Parkinson's disease: progression to dementia. Mov Disord. 2006 Sep;21(9):1343-9. https://doi.org/10.1002/mds.20974
6 Goldman JG, Litvan I. Mild cognitive impairment in Parkinson's disease. Minerva Med. 2011 Dec;102(6):441-59.
7 Emre M. Dementia associated with Parkinson's disease. Lancet Neurol. 2003 Apr;2(4):229-37. https://doi.org/10.1016/S1474-4422(03)00351-X
8 Fillenbaum GG, van Belle G, Morris JC, Mohs RC, Mirra SS, Davis PC et al. Consortium to establish a registry for Alzheimer's disease (CERAD): the first twenty years. Alzheimers Dement. 2008 Mar;4(2):96-109. https://doi.org/10.1016/j.jalz.2007.08.005
9 Rossetti HC, Munro Cullum C, Hynan LS, Lacritz LH. The CERAD neuropsychologic battery total score and the progression of Alzheimer disease. Alzheimer Dis Assoc Disord. 2010 Apr-Jun;24(2):138-42. https://doi.org/10.1097/WAD.0b013e3181b76415
10 Bertolucci PH, Okamoto IH, Brucki SM, Siviero MO, Toniolo Neto J, Ramos LR. Applicability of the CERAD neuropsychological battery to Brazilian elderly. Arq Neuropsiquiatr. 2001 Sep;59 3-A:532-6. https://doi.org/10.1590/S0004-282X2001000400009
11 Bilello M, Doshi J, Nabavizadeh SA, Toledo JB, Erus G, Xie SX et al. Correlating cognitive decline with white matter lesion and brain atrophy magnetic resonance imaging measurements in Alzheimer's disease. J Alzheimers Dis. 2015;48(4):987-94. https://doi.org/10.3233/JAD-150400
12 Haanpaa RM, Suhonen NM, Hartikainen P, Koivisto AM, Moilanen V, Herukka SK et al. The CERAD neuropsychological battery in patients with frontotemporal lobar degeneration. Dement Geriatr Cogn Dis Extra. 2015 Apr;5(1):147-54. https://doi.org/10.1159/000380815
13 Camargo CH, Justus FF, Retzlaff G. The effectiveness of reality orientation in the treatment of Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2015 Aug;30(5):527-32. https://doi.org/10.1177/1533317514568004
14 Daniel SE, Lees AJ. Parkinson's Disease Society Brain Bank, London: overview and research. J Neural Transm Suppl. 1993;39:165-72.
15 Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology. 1967 May;17(5):427-42. https://doi.org/10.1212/WNL.17.5.427
16 Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P et al. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord. 2008 Nov;23(15):2129-70. https://doi.org/10.1002/mds.22340
17 Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993 Nov;43(11):2412-4. https://doi.org/10.1212/WNL.43.11.2412-a
18 Karrasch M, Laatu S, Martikainen K, Marttila R. CERAD test performance and cognitive impairment in Parkinson's disease. Acta Neurol Scand. 2013 Dec;128(6):409-13. https://doi.org/10.1111/ane.12138
19 Kiesmann M, Chanson JB, Godet J, Vogel T, Schweiger L, Chayer S et al. The Movement Disorders Society criteria for the diagnosis of Parkinson's disease dementia: their usefulness and limitations in elderly patients. J Neurol. 2013 0ct;260(10):2569-79. https://doi.org/10.1007/s00415-013-7018-8
20 Riedel O, Klotsche J, Spottke A, Deuschl G, Forstl H, Henn F et al. Cognitive impairment in 873 patients with idiopathic Parkinson's disease results from the German study on epidemiology of Parkinson's disease with dementia (GEPAD). J Neurol. 2008 Feb;255(2):255-64. https://doi.org/10.1007/s00415-008-0720-2
21 Buter TC, van den Hout A, Matthews FE, Larsen JP, Brayne C, Aarsland D. Dementia and survival in Parkinson disease: a 12-year population study. Neurology. 2008 Mar;70(13):1017-22. https://doi.org/10.1212/01.wnl.0000306632.43729.24
22 Aarsland D, Andersen K, Larsen JP, Lolk A, Nielsen H, Kragh-Sørensen P. Risk of dementia in Parkinson's disease: a community-based, prospective study. Neurology. 2001 Mar;56(6):730-6. https://doi.org/10.1212/WNL.56.6J30
23 Zhu K, van Hilten JJ, Marinus J. Predictors of dementia in Parkinson's disease; findings from a 5-year prospective study using the SCOPA-COG. Parkinsonism Relat Disord. 2014 Sep;20(9):980-5. https://doi.org/10.1016/j.parkreldis.2014.06.006
24 Levy G, Jacobs DM, Tang MX, Cçté LJ, Louis ED, Alfaro B et al. Memory and executive function impairment predict dementia in Parkinson's disease. Mov Disord. 2002 Nov;17(6):1221-6. https://doi.org/10.1002/mds.10280
25 Marinus J, Visser M, Verwey NA, Verhey FR, Middelkoop HA, Stiggelbout AM et al. Assessment of cognition in Parkinson's disease. Neurology. 2003 Nov;61(9):1222-8. https://doi.org/10.1212/01.WNL.0000091864.39702.1C
26 Wolfsgruber S, Jessen F, Wiese B, Stein J, Bickel H, Mosch E et al. The CERAD neuropsychological assessment battery total score detects and predicts Alzheimer disease dementia with high diagnostic accuracy. Am J Geriatr Psychiatry. 2014 Oct;22(10):1017-28. https://doi.org/10.1016/j.jagp.2012.08.021
27 Tedrus GM, Fonseca LC, Letro GH, Bossoni AS, Samara AB. Dementia and mild cognitive impairment in patients with Parkinson's disease. Arq Neuropsiquiatr. 2009 Jun;67(2b 2B):423-7. https://doi.org/10.1590/S0004-282X2009000300010
28 Stern Y, Richards M, Sano M, Mayeux R. Comparison of cognitive changes in patients with Alzheimer's and Parkinson's disease. Arch Neurol. 1993 Oct;50(10):1040-5. https://doi.org/10.1001/archneur.1993.00540100035011
29 Helkala EL, Laulumaa V, Soininen H, Riekkinen PJ. Different error pattern of episodic and semantic memory in Alzheimer's disease and Parkinson's disease with dementia. Neuropsychologia. 1989;27(10):1241-8. https://doi.org/10.1016/0028-3932(89)90036-5