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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2018; 76(03): 145-149
DOI: 10.1590/0004-282X20180003
Article

Can the CERAD neuropsychological battery be used to assess cognitive impairment in Parkinson's disease?

A bateria neuropsicológica do CERAD pode ser usada para avaliação cognitiva em pacientes com doença de Parkinson?
Carlos Henrique Ferreira Camargo
1   Universidade Estadual de Ponta Grossa, Hospital Universitário Regional dos Campos Gerais, Serviço de Neurologia, Ponta Grossa PR, Brasil
,
Augusto Bronzini
1   Universidade Estadual de Ponta Grossa, Hospital Universitário Regional dos Campos Gerais, Serviço de Neurologia, Ponta Grossa PR, Brasil
,
Eduardo de Souza Tolentino
1   Universidade Estadual de Ponta Grossa, Hospital Universitário Regional dos Campos Gerais, Serviço de Neurologia, Ponta Grossa PR, Brasil
,
Camila Medyk
1   Universidade Estadual de Ponta Grossa, Hospital Universitário Regional dos Campos Gerais, Serviço de Neurologia, Ponta Grossa PR, Brasil
,
Gustavo Leopold Schultz-Pereira
1   Universidade Estadual de Ponta Grossa, Hospital Universitário Regional dos Campos Gerais, Serviço de Neurologia, Ponta Grossa PR, Brasil
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ABSTRACT

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuropsychological battery was created to assess cognitive impairment in Alzheimer's disease (AD) but it is widely-used for various dementias. The aim of this study was to analyze the efficacy of using the CERAD battery in the assessment of patients with Parkinson's disease. Forty-nine patients with Parkinson's disease were divided into two groups (one with dementia and one without) using the Movement Disorder Society criteria for Parkinson's disease dementia. Cognitive deficits were assessed with the Clinical Dementia Rating Scale as the gold standard, and the CERAD. The ROC curve for the CERAD battery had an area under the curve = 0.989 (95% CI = 0.967 – 1, p<0.0001). Among the CERAD subtests, verbal fluency had the worst accuracy, and word list learning had the best accuracy. Despite the limits of this study, the CERAD battery can be efficient for assessment of cognitive deficits in Parkinson's disease patients.

RESUMO

A Bateria Neuropsicológica do Consortium to Establish a Registry for Alzheimer's Disease (CERAD) foi criada para a avaliação da doença de Alzheimer (DA), mas é usada em várias demências. O objetivo deste estudo foi avaliar a efetividade dessa bateria na avaliação de pacientes com doença de Parkinson (DP). Foram avaliados 49 pacientes com DP sendo aplicadas CDR, como padrão-ouro e CERAD. Os pacientes foram divididos em dois grupos: com e sem demência, a partir dos critérios para DPP pela Movement Disorders Society. A curva ROC para o CERAD resultou em uma AUC=0.989 (95% CI = 0.967 – 1, p<0.0001). Entre os subtestes do CERAD, fluência verbal obteve a pior acurácia, e aprendizado de lista de palavras, a melhor. Apesar das limitações do estudo, a bateria do CERAD pode ser uma ferramenta eficaz na avaliação de déficits cognitivos em pacientes com DP

Keywords

Parkinson's disease - dementia - cognition

Palavras-chave

doença de Parkinson - demência - cognição


Publikationsverlauf

Eingereicht: 19. Juni 2017

Angenommen: 22. November 2017

Artikel online veröffentlicht:
28. August 2023

© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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