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DOI: 10.1590/0004-282X20180133
Restless legs syndrome in end-stage renal disease patients undergoing hemodialysis
Síndrome de Piernas Inquietas en enfermedad renal crónica terminal en hemodiálisis
ABSTRACT
Restless legs syndrome (RLS) is a frequent complication of hemodialysis that has been associated with poor quality of life and increased risk for complications. Nevertheless, few studies regarding this entity exist in resource-limited settings.
Objectives: To determine the prevalence of RLS among Mexican patients on hemodialysis; and compare these patients with a control group of the same population.
Methods: We recruited 105 hemodialysis patients. Restless legs syndrome was diagnosed according to the updated criteria set out by the International RLS Study Group. We selected patients who did not meet the criteria, as controls.
Results: We found an RLS prevalence of 18%. The RLS patients had a significantly higher prevalence of iron deficiency anemia and uremic pruritus. None of the patients reported RLS symptoms prior to hemodialysis initiation.
Conclusions: Restless legs syndrome is common among Mexican patients on hemodialysis. Larger studies are required to address the impact of RLS in hemodialysis patients.
RESUMEN
El síndrome de piernas inquietas (SPI) es una complicación de la hemodiálisis que se ha asociado con menor calidad de vida y riesgo aumentado de complicaciones. Sin embargo, existen pocos estudios acerca de esta entidad en escenarios de recursos limitados.
Objetivos: Determinar la prevalencia de SPI en pacientes mexicanos en hemodiálisis, y comparar las características con un grupo control de la misma población.
Métodos: Reclutamos 105 pacientes en hemodiálisis. El SPI se diagnosticó de acuerdo con los criterios actualizados del grupo de estudio internacional del síndrome de piernas inquietas. Seleccionamos a los pacientes que no cumplieron dichos criterios como controles.
Resultados: Encontramos una prevalencia de SPI del 18%. Los pacientes con SPI tenían una prevalencia más alta de anemia ferropénica, y prurito urémico. Ninguno de los pacientes reportó síntomas de SPI previo a iniciar la hemodiálisis.
Conclusiones: El SPI es frecuente en pacientes mexicanos en hemodiálisis; se requieren estudios más grandes para evaluar el impacto del síndrome en ésta población.
Publikationsverlauf
Eingereicht: 16. Juni 2018
Angenommen: 25. September 2018
Artikel online veröffentlicht:
22. August 2023
© 2023. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
- 1 Gkizlis V, Giannaki CD, Karatzaferi C, Hadjigeorgiou GM, Mihas C, Koutedakis Y et al. Uremic versus idiopathic restless legs syndrome: impact on aspects related to quality of life. ASAIO J. 2012 Nov-Dec;58(6):607-11. https://doi.org/10.1097/MAT.0b013e31826d6090
- 2 Dikici S, Bahadir A, Baltaci D, Ankarali H, Eroglu M, Ercan N et al. Association of anxiety, sleepiness, and sexual dysfunction with restless legs syndrome in hemodialysis patients. Hemodial Int. 2014 Oct;18(4):809-18. https://doi.org/10.1111/hdi.12175
- 3 La Manna G, Pizza F, Persici E, Baraldi O, Comai G, Cappuccilli ML et al. Restless legs syndrome enhances cardiovascular risk and mortality in patients with end-stage kidney disease undergoing long-term haemodialysis treatment. Nephrol Dial Transplant. 2011 Jun;26(6):1976-83. https://doi.org/10.1093/ndt/gfq681
- 4 Lin CH, Sy HN, Chang HW, Liou HH, Lin CY, Wu VC et al. Restless legs syndrome is associated with cardio/cerebrovascular events and mortality in end-stage renal disease. Eur J Neurol. 2015 Jan;22(1):142-9. https://doi.org/10.1111/ene.12545
- 5 Innes KE, Selfe TK, Agarwal P. Restless legs syndrome and conditions associated with metabolic dysregulation, sympathoadrenal dysfunction, and cardiovascular disease risk: a systematic review. Sleep Med Rev. 2012 Aug;16(4):309-39. https://doi.org/10.1016/j.smrv.2011.04.001
- 6 Gholamrezaei A, Amra B, Mortazavi M. Cardiovascular risk and mortality in end-stage renal disease patients with restless legs syndrome; need for further investigation and looking for underlying mechanisms. Sleep Med. 2013 Apr;14(4):385-6. https://doi.org/10.1016/j.sleep.2012.11.015
- 7 Katsanos AH, Kosmidou M, Konitsiotis S, Tsivgoulis G, Fiolaki A, Kyritsis AP et al. Restless legs syndrome and cerebrovascular/cardiovascular events: systematic review and meta-analysis. Acta Neurol Scand. 2018 Jan;137(1):142-8. https://doi.org/10.1111/ane.12848
- 8 Lajous M, Kurth T, Catzin-Kuhlmann A, Romieu I, Lopez-Ridaura R. [Prevalence of restless legs syndrome in 69,830 Mexican women]. Rev Invest Clin. 2014 Jul-Aug;66(4):303-6. Spanish.
- 9 Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria: history, rationale, description, and significance. Sleep Med. 2014 Aug;15(8):860-73. https://doi.org/10.1016/j.sleep.2014.03.025
- 10 Garcia-Borreguero D, Williams AM. An update on restless legs syndrome (Willis-Ekbom disease): clinical features, pathogenesis and treatment. Curr Opin Neurol. 2014 Aug;27(4):493-501. https://doi.org/10.1097/WC0.20180133201801330117
- 11 Rizzo G, Manners D, Testa C, Tonon C, Vetrugno R, Marconi S et al. Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging. Mov Disord. 2013 Nov;28(13):1886-90. https://doi.org/10.1002/mds.25576
- 12 Oexle K, Schormair B, Ried JS, Czamara D, Heim K, Frauscher B et al. Dilution of candidates: the case of iron-related genes in restless legs syndrome. Eur J Hum Genet. 2013 Apr;21(4):410-4. https://doi.org/10.1038/ejhg.2012.193
- 13 Pisoni RL, Wikstrom B, Elder SJ, Akizawa T, Asano Y, Keen ML et al. Pruritus in haemodialysis patients: international results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant. 2006 Dec;21(12):3495-505. https://doi.org/10.1093/ndt/gfi461
- 14 Lerma EV. Are restless legs syndrome, pruritus or hiccoughs surrogates for inadequate dialysis? Semin Dial. 2011 Jul-Aug;24(4):406-7. https://doi.org/10.1111/j.1525-139X.2011.00888.x
- 15 Akhyani M, Ganji MR, Samadi N, Khamesan B, Daneshpazhooh M. Pruritus in hemodialysis patients. BMC Dermatol. 2005 Jun;5(1):7. https://doi.org/10.1186/1471-5945-5-7
- 16 Makhlough A, Emadi N, Sedighi O, Khademloo M, Bicmohamadi AR. Relationship between serum intact parathyroid hormone and pruritus in hemodialysis patients. Iran J Kidney Dis. 2013 Jan;7(1):42-6.
- 17 Gade K, Blaschke S, Rodenbeck A, Becker A, Anderson-Schmidt H, Cohrs S. Uremic restless legs syndrome (RLS) and sleep quality in patients with end-stage renal disease on hemodialysis: potential role of homocysteine and parathyroid hormone. Kidney Blood Press Res. 2013;37(4-5):458-63. https://doi.org/10.1159/000355727
- 18 Santos RS, Coelho FM, Silva BC, Graciolli FG, Dominguez WV, Menezes Montenegro FL et al. Parathyroidectomy improves restless leg syndrome in patients on hemodialysis. PLoS One. 2016 May;11(5):e0155835. https://doi.org/10.1371/journal.pone.0155835