Journal of Pediatric Infectious Diseases, Table of Contents J Pediatr Infect Dis 2010; 05(02): 119-124DOI: 10.3233/JPI-2010-0245 Georg Thieme Verlag KG Stuttgart – New YorkMultidrug resistant Klebsiella pneumoniae in NICU – what next? Trend of antibiotic resistance Amit Tagare a Department of Neonatology, King Edward Memorial Hospital, Rasta Peth, Pune, India , Sandeep Kadam a Department of Neonatology, King Edward Memorial Hospital, Rasta Peth, Pune, India , Umesh Vaidya a Department of Neonatology, King Edward Memorial Hospital, Rasta Peth, Pune, India , Jayant Deodhar b Department of Pediatrics, King Edward Memorial Hospital, Rasta Peth, Pune, India , Anand Pandit b Department of Pediatrics, King Edward Memorial Hospital, Rasta Peth, Pune, India› Author AffiliationsSubject Editor: Recommend Article Abstract PDF Download Buy Article Abstract Multidrug resistant (MDR) Klebsiella pneumoniae an increasing cause of neonatal sepsis in India. This observational study was designed to monitor temporal change in prevalence of K. pneumoniae as a causative organism for neonatal sepsis and its sensitivity pattern. The time period was divided into four time frames of six months each [designated A (1/10/2006–31/03/2007) to D (1/04/2008–30/09/2008)]. K. pneumoniae isolation in all cultures sent from neonatal intensive care units doubled in time frame D (6.3%) compared to time frame A (3.0). Similarly, the percentage of total positive cultures in the neonatal intensive care unit that were K. pneumoniae also doubled (27.8% in A to 55.6% in D). K. pneumoniae sepsis tripled in inborn neonates (15.4% in A to 47.1% in D). Incidence of MDR K. pneumoniae increased from 0% in time frame A to 76.5% in time frame D. Resistance against ampicillin and third generation cephalosporins (cefotaxime and ceftazidime) remained 100% in all time frames. Carbapenem (meropenem and imipenem) resistance increased from 0% in time frame A and B to 41.2% in time frame D. Death due to K. pneumoniae sepsis showed brisk resurgence in time frame D (17.6%) compared to time frame C (10%). Lower gestational age and birth weight were associated with higher mortality. MDR K. pneumoniae is emerging as a more frequent cause of neonatal sepsis. There is an dincreasing threat of combined quinolone and carbapenem resistant MDR K. pneumoniae. Keywords KeywordsNeonatal sepsis - antibiotics - carbapenems - blood culture PDF (617 kb)
