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J Pediatr Infect Dis 2011; 06(01): 063-066
DOI: 10.3233/JPI-2011-0297
Georg Thieme Verlag KG Stuttgart – New York

Rosai-Dorfman Disease: An unusual cause of fever of unknown origin (FUO) and anterior cervical adenopathy in a child

Burke A. Cunha
a   Infectious Disease Division, Winthrop-University Hospital, Mineola, NY, USA
d   State University of New York School of Medicine, Stony Brook, NY, USA
,
Nicole Durie
b   Department of Pathology, Winthrop-University Hospital, Mineola, NY, USA
,
Elena Selbs
b   Department of Pathology, Winthrop-University Hospital, Mineola, NY, USA
,
Mark Weinblatt
c   Department of Pediatric Oncology, Winthrop-University Hospital, Mineola, NY, USA
d   State University of New York School of Medicine, Stony Brook, NY, USA
,
Brian P. McDermott
a   Infectious Disease Division, Winthrop-University Hospital, Mineola, NY, USA
d   State University of New York School of Medicine, Stony Brook, NY, USA
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Publication History

29 January 2010

04 October 2010

Publication Date:
28 July 2015 (online)

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Abstract

In children, cervical adenopathy and fever is a common diagnostic dilemma. We present an unusual case of fever with anterior cervical adenopathy mimicking lymphoma that was diagnosed by as Rosai-Dorfman disease (RD) by lymph node biopsy. RD disease typically presents in childhood with cervical adenopathy. Less commonly, RD may involve extra-nodal sites as well, including the skin (the most common extranodal site), central nervous system (CNS), eye, liver, spleen, pancreas, or kidney. Lymph node biopsy is diagnostic and to differentiates RD disease from other causes of lymphadenopathy such as lymphoma.

Keywords

FUO - mimics of lymphoma - sinus histiocytosis - lympadenopathy