Associations between birth and one year anthropometric measurements and IGF2 and IGF2R genetic variants in African American and Caucasian American infants

Adriana C. Vidal; Francine Overcash; Susan K. Murphy; Amy P. Murtha; Joellen M. Schildkraut; Michele R Forman; Wendy Demark-Wahnefried; Joanne Kurtzberg; David Skaar; Randy L. Jirtle; Cathrine Hoyo

doi:10.3233/PGE-13064

Journal of Pediatric Genetics, Table of Contents

J Pediatr Genet 2013; 02(03): 119-127
DOI: 10.3233/PGE-13064

Georg Thieme Verlag KG Stuttgart – New York

Associations between birth and one year anthropometric measurements and IGF2 and IGF2R genetic variants in African American and Caucasian American infants

Adriana C. Vidal^*

^aDepartment of Obstetrics and Gynecology, and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC, USA

,

Francine Overcash^*

^aDepartment of Obstetrics and Gynecology, and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC, USA

,

Susan K. Murphy

^bDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University School of Medicine, Durham, NC, USA

,

Amy P. Murtha

^cDepartment of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Duke University School of Medicine, Durham, NC, USA

,

Joellen M. Schildkraut

^dDepartment of Community and Family Medicine and Program of Cancer Detection, Prevention and Control, Duke University Medical Center, Durham, NC, USA

,

Michele R Forman

^eDepartment of Epidemiology, MD Anderson Cancer Center, Houston, TX, USA

,

Wendy Demark-Wahnefried

^fDepartment of Behavioral Science, MD Anderson Cancer Center, Houston, TX, USA

,

Joanne Kurtzberg

^gDepartment of Pathology and Carolinas Cord Blood Banking Project, Duke University Medical Center, Durham, NC, USA

,

David Skaar

^hDepartment of Radiation Oncology, Duke University Medical Center, Durham, NC, USA

,

Randy L. Jirtle

^aDepartment of Obstetrics and Gynecology, and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC, USA

,

Cathrine Hoyo

^aDepartment of Obstetrics and Gynecology, and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC, USA

› Author Affiliations
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Abstract

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Abstract

Insulin-like growth factor 2 receptor (IGF2R) and insulin-like growth factor 2 (IGF2) genetic variants have been inconsistently associated with low birth weight and birth length in Caucasian and Asian infants, however few studies have included African Americans (AA). Generalized linear models and logistic regression models were used to examine associations between IGF2R single nucleotide polymorphisms (SNP) rs629849 and rs8191754, and IGF2 SNP rs680 and infant anthropometric measurements, in a racially diverse birth cohort in Durham County, North Carolina. Caucasian American (CA) carriers of the IGF2R SNP rs629849 were heavier (P = 0.02) and longer (P = 0.003) at birth, however body size at age 1 yr was similar to that of AA. Birth length significantly differed between carriers and non-carriers of the IGF2 rs680 variant in both AA (P = 0.04) and CA infants (P = 0.03). Both AA and CA carriers were 1 cm shorter at birth compared to non-carriers. We found no evidence for an association between rs8191754 and infant anthropometric measurements. Associations between SNPs and one year weight gain were only observed for rs680; CA infant carriers of rs680 variants weighed less than non-carriers at year one (P = 0.03); however, no associations were found in AA infants at year one. Larger studies using ancestral markers are required to disentangle these associations.

Keywords

Insulin-like growth factor 2 receptor - insulin-like growth factor 2 - genetic variants - African Americans - race/ethnicity

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