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J Pediatr Intensive Care 2013; 02(04): 181-185
DOI: 10.3233/PIC-13065
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Inhaled nitric oxide and sildenafil therapy for a pediatric patient with multiple pulmonary arteriovenous malformations

Julie Pantaleoni
a   Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, USA
,
Kourosh Parsapour
b   Department of Pediatric Critical Care Medicine University of California, Irvine School of Medicine, Irvine, CA, USA
,
Alexander A. Kon
c   Pediatric Intensive Care Unit, Naval Medical Center San Diego and University of California, San Diego School of Medicine, San Diego, CA, USA
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30. Juni 2013

10. Oktober 2013

Publikationsdatum:
28. Juli 2015 (online)

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Abstract

Pulmonary arteriovenous malformations may result in intrapulmonary shunting and hypoxemia, and often are treated by embolization or surgical resection. Previous reports have demonstrated effective treatment of hypoxia with inhaled nitric oxide in the acute setting. In this report, we describe a child with severe hypoxemia secondary to an inoperable pulmonary arteriovenous malformation that was initially managed with the use of nitric oxide followed by long term management with the phosphodiesterase-5 inhibitor, sildenafil.

Keywords

Arteriovenous malformations - nitric oxide - phosphodiesterase-5 inhibitors