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Nuklearmedizin 2008; 47(04): 167-174
DOI: 10.3413/nukmed-0153
Original article
Schattauer GmbH

The simplified reference tissue model for SPECT/PET brain receptor studies

Interpretation of its parametersDas vereinfachte Referenzgewebemodell für SPECT/PETNeurorezeptorstudienInterpretation der Parameter
R. Buchert
1   Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf
,
F. Thiele
2   Philips Research Laboratories Aachen, Germany
› Author Affiliations
Further Information

Publication History

Received: 05 October 2007

accepted in revised form: 03 March 2008

Publication Date:
04 January 2018 (online)

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Summary

Aim: The SRTM (simplified reference tissue model) of brain receptor imaging assumes that the time activity curve in the receptor-rich region of interest can be fitted satisfactorily by the 1-tissue compartment model. This assumption has been formulated by a rather restrictive constraint on the rate constants. Empirically, the SRTM might well describe also tracers which do not fulfil this constraint, such as [11C]raclopride, for example. However, this has not been justified rigorously. Methods: The requirements for the SRTM to be applicable are analyzed in detail. Results: The SRTM is applicable under a less restrictive constraint than described previously. The interpretation of the SRTM parameters R1 and K2 in physiological terms depends on the constraint, while the interpretation of BPND does not. Conclusion: Correct interpretation of the results of the SRTM is tracer specific. In particular, the parameter R1, which in case of compliance with the original constraint might be used to detect perfusion and/or extraction effects, might not be appropriate for this purpose in case of raclopride-like tracers.

Zusammenfassung

Ziel: Die Vereinfachung der Operationsgleichung des vereinfachten Referenzgewebemodells (SRTM) der Neurorezeptorbildgebung beruht auf der Annahme, dass die Zeitaktivitätskurve in den interessierenden rezeptorreichen Gehirnregionen hinreichend gut durch ein 1-Gewebe-Kompartment-Modell beschreibbar ist. Formelmäßig wurde dies durch eine restriktive Nebenbedingung für die Ratenkonstanten in das Modell eingeführt. Die Erfahrung zeigt, dass mit SRTM auch die Kinetik von Tracern beschrieben werden kann, die diese Nebenbedingung nicht erfüllen, z. B. [11C]Racloprid. Der Grund hierfür ist bisher nicht untersucht. Methoden: Wir beschreiben die Bedingungen für die Anwendbarkeit des SRTM. Ergebnisse: Das SRTM ist auch unter einer weniger restriktiven Nebenbedingung für die Ratenkonstanten anwendbar. Die physiologische Bedeutung der SRTM-Parameter R1 und K2 hängt jedoch von der Nebenbedingung ab. Dies gilt nicht für BPND. Schlussfolgerung: Die korrekte Interpretation der Ergebnisse aus der Anwendung des SRTM ist tracerspezifisch. So kann z. B. der Parameter R1, der bei Gültigkeit der restriktiven Nebenbedingung zur Detektion von Perfusions-und/oder Extraktionseffekten genutzt kann, bei Racloprid-artigen Tracern nicht ohne Weiteres dazu eingesetzt werden.

Keywords

Receptor imaging - tracer kinetic modeling - simplified reference tissue method - compartment model - positron emission tomography - raclopride

Schlüsselwörter

Neurorezeptor-Bildgebung - kinetische Modellierung - vereinfachtes Referenzgewebemodell - Kompartmentmodell - Positronenemissionstomographie - Racloprid
 

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