Nutritional secondary hyperparathyroidism in two cats

Summary

Two three-month-old, intact female Abyssinian cats were presented with a history of lameness, constipation and ataxia. The cats had been fed a diet composed almost exclusively of meat. Both showed severe osteopenia and multiple pathological fractures on radiography. Following euthanasia of the more severely affected cat, postmortem examination revealed changes consistent with nutritional secondary hyperparathyroidism and fibrous osteodystrophy, such as cortical thinning, massive connective tissue invasion in the diaphysis of long bones, and hypertrophy of the chief cells in both parathyroid glands. After introducing a balanced commercial diet to the surviving cat, bone mineralisation improved from the baseline value, and at subsequent examinations at three, six and 22 weeks later, as indicated by bone mineral density measurements obtained by dual-energy X-ray absorptiometry and computed tomography.

Keywords

All meat syndrome - feline - fibrous osteodystrophy - hyperparathyroidism

• References

• 1 Miller RM.. Nutritional secondary hyperparathyroidism. (A review of etiology, symptomatology and treatment in companion animals). Vet Med Small Anim Clin 1969; 64: 400-408.
• 2 Nap RC, Hazewinkel HA.. Growth and skeletal development in the dog in relation to nutrition; a review. Vet Q 1994; 16: 50-59.
• 3 Tomsa K, Glaus T, Hauser B. et al. Nutritional secondary hyperparathyroidism in six cats. J Small Anim Pract 1999; 40: 533-539.
• 4 Watson AD, Porges WL.. Osteodystrophy in a kitten. Aust Vet J 1997; 75: 30-31.
• 5 Scott P P.. Calcium and iodine deficiency in meat-fed cats with reference to osteogenesis imperfecta. Proc Br Small Anim Vet Assoc 1959; 84-90.
• 6 Scott PP.. Nutritional secondary hyperparathyroidism in the cat. Vet Med Small Anim Clin 1967; 62: 42-44.
• 7 Krook L, Barrett RB, Usui K. et al. Nutritional secondary hyperparathyroidism in the cat. Cornell Vet 1963; 53: 224-240.
• 8 Rowland GN, Capen CC, Nagode LA.. Experimental hyperparathyroidism in young cats. Pathol Vet 1968; 5: 504-519.
• 9 Grier SJ, Turner AS, Alvis MR.. The use of dual-energy x-ray absorptiometry in animals. Invest Radiol 1996; 31: 50-62.
• 10 Nielsen DH, McEvoy FJ, Madsen MT. et al. Relationship between bone strength and dual-energy X-ray absorptiometry measurements in pigs. J Anim Sci 2007; 85: 667-672.
• 11 Schneider S, Breit SM, Gramp S. et al. Comparative assessment of bone mineral measurements obtained by use of dual-energy x-ray absorptiometry, peripheral quantitative computed tomography, and chemical-physical analyses in femurs of juvenile and adult dogs. Am J Vet Res 2004; 65: 891-900.
• 12 Speakman JR, Booles D, Butterwick R.. Validation of dual energy X-ray absorptiometry (DXA) by comparison with chemical analysis of dogs and cats. Int J Obes Relat Metab Disord 2001; 25: 439-447.
• 13 Turner AS, Norrdin RW, Gaarde S. et al. Bone mineral density in feline mucopolysaccharidosis VI measured using dual-energy X-ray absorptiometry. Calcif Tissue Int 1995; 57: 191-195.
• 14 Lorinson K, Loebcke S, Skalicky M. et al. Signalment differences in bone mineral content and bone mineral density in canine appendicular bones. Vet Comp Orthop Traumatol 2007; 21: 147-151.
• 15 Gorman SC, Kraus KH, Keating JH. et al. In vivo dynamization of canine tibial fractures using the Securos external skeletal fixation system. Vet Comp Orthop Traumatol 2005; 18: 199-207.
• 16 Damilakis J, Maris TG, Karantanas AH.. An update on the assessment of osteoporosis using radiologic techniques. Eur Radiol 2007; 17: 1591-1602.
• 17 Markel MD, Morin RL, Wikenheiser MA. et al. Multiplanar quantitative computed tomography for bone mineral analysis in dogs. Am J Vet Res 1991; 52: 1479-1483.
• 18 Nazarian A, Cory E, Muller R. et al. Shortcomings of DXA to assess changes in bone tissue density and microstructure induced by metabolic bone diseases in rat models. Osteoporosis International 2009; 20: 123-132.
• 19 Barber PJ, Elliott J, Torrance AG.. Measurement of feline intact parathyroid hormone: assay validation and sample handling studies. J Small Anim Pract 1993; 34: 614-620.
• 20 La Flamme DP, Kealy RD, Schmidt DA.. Estimation of body fat by body condition score. In: Proceedings. Twelfth Annual Veterinary Medical Forum, American College of Veterinary Internal Medicine; San Francisco, CA: 1994: 985.
• 21 Hazewinkel HAW.. Nutrition in relation to skeletal growth deformities. J Small Anim Pract 1989; 30: 625-630.
• 22 Kirk CA, Debwekeler J, Armstrong PJ.. Normal Cats. In: Small Animal Clinical Nutrition. Hand MS, Thatcher CD, Remillard RL, Roundebush P. (editors) Missouri: Walsworth Publishing Company; 2000: 329-335.
• 23 Turner AS, Norrdin RW, Gaarde S. et al. Bone mineral density in feline mucopolysaccharidosis VI measured using dual-energy X-ray absorptiometry. Calcif Tissue Int 1995; 57: 191-195.
• 24 Nishihara S, Fujita H, Iida T. et al. Evaluation of osteoporosis in X-ray CT examination: a preliminary study for an automatic recognition algorithm for the central part of a vertebral body using abdominal X-ray CT images. Comput Med Imaging Graph 2005; 29: 259-266.
• 25 Siu WS, Qin L, Leung KS.. pQCT bone strength index may serve as a better predictor than bone mineral density for long bone breaking strength. J Bone Miner Metab 2003; 21: 316-322.
• 26 Bousson V, Bergot C, Meunier A. et al. CT of the middiaphyseal femur: cortical bone mineral density and relation to porosity. Radiology 2000; 217: 179-187.