Chondrosarcoma in the humerus of a goat

T. Schmid; M. Hilbe; S. Ohlert; K. Nuss

doi:10.3415/VCOT-09-11-0116

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 2010; 23(04): 273-276
DOI: 10.3415/VCOT-09-11-0116

Case Report

Schattauer GmbH

Chondrosarcoma in the humerus of a goat

Authors

T. Schmid

¹Department of Farm Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
M. Hilbe

²Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
S. Ohlert

³Division for Diagnostic, Imaging and Radio-Oncology, Department of Small Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
K. Nuss

¹Department of Farm Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland

Abstract

Summary

The clinical, radiographical and histo-pathological findings of a chondrosarcoma in the humerus of a goat are discussed. An 11-year-old female Saanen goat was admitted for evaluation of chronic, progressive left forelimb lameness. Clinical examination revealed signs of pain in the shoulder region. Radiographs of the scapulohumeral joint showed a large lytic lesion of the proximal third of the humerus with cortical destruction, intralesional calcification and marked periosteal reactions. Differential diagnoses included aggressive bone lesions as seen with osteomyelitis or a primary bone tumour, such as osteosarcoma, chondrosarcoma or fibrosarcoma. The goat was euthanatized for humane reasons because of the poor prognosis. On the basis of the histopathological findings, the lesion was diagnosed as grade II chondrosarcoma. The tumour had already spread to the lungs and the left prescapular lymph node at the time of diagnosis.

Keywords

Goat - lameness - tumour - chondrosarcoma - humerus

Full Text

References

References
1 Thompson K.G. PRR. Tumours of bones. In Meuten DJ. editor. Tumors in Domestic Animals. 4 ed. Ames, Iowa: Iowa State Press; 2002. p 245-317.
2 Nielsen SW. Comparative pathology of bone tumors in animals, with particular emphasis on the dog. Recent Results Cancer Res 1976; (54) 3-16.
3 Thompson KG, Pool RR. Chondrosarcoma. In Slayter MV, Boosinger TR, Pool RR. et al. editors. Histological Classification of Bone and Joint Tumors of Domestic Animals. Washigton, D.C.: Armed Forces Institute of Pathology. American Registry of Pathology; 1994. p 283-290.
4 Richardson DW, Acland HM. Chondrosarcoma in a cow. Cornell Vet 1983; 73: 137-143.
5 Acland HM. Chondrosarcoma in a cow. J Comp Pathol 1983; 93: 585-589.
6 Manson FJ, Leaver JD. The influence of concentration amount and clinical lameness in dairy cattle. Anim Prod 1988; 47: 185-190.
7 Sullivan DJ. Cartilaginous tumours (chondroma and chondrosarcoma) in animals. Am J Vet Res 1960; 21: 531-535.
8 Streitbuerger A, Hardes J, Gebert C. et al. [Cartilage tumours of the bone. Diagnosis and therapy]. Orthopade 2006; 35: 871-881. quiz 82.
9 Meuten DJ. Chondrosarcoma. In Meuten DJ. editor. Tumors in Domestic Animals. 4 ed. Ames, Iowa: Iowa State Press; 2002. p 11
10 Beytut E, Kilic E, Ozturk S. et al. Nasal chondrosarcoma in a Simmental cow. Can Vet J 2006; 47: 349-351.
11 Martinek B, Bago Z, Flock M. et al. Chondrosarcoma in a simmental cow: Clinical, ultrasonographic, radiographic and pathological findings. Vet J 2006; 172: 181-184.
12 Riddle Jr WE , Wheat JD. Chondrosarcoma in a horse. J Am Vet Med Assoc 1971; 158: 1674-1677.
13 Bertone AL, Powers BE, Turner AS. Chondrosarcoma in the radius of a horse. J Am Vet Med Assoc 1984; 185: 534-537.
14 Okada K, Hasegawa T, Tateishi U. et al. Dedifferentiated chondrosarcoma with telangiectatic osteosarcoma-like features. J Clin Pathol 2006; 59: 1200-1202.
15 Brodey RS, Misdorp W, Riser WH. et al. Canine skeletal chondrosarcoma: a clinicopathologic study of 35 cases. J Am Vet Med Assoc 1974; 165: 68-78.
16 Farese JP, Kirpensteijn J, Kik M. et al. Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by ampu-tation: a Veterinary Society of Surgical Oncology retrospective study. Vet Surg 2009; 38: 914-919.
17 Rozeman LB, Cleton-Jansen AM, Hogendoorn PC. Pathology of primary malignant bone and cartilage tumours. Int Orthop 2006; 30: 437-444.
18 Lee FY, Mankin HJ, Fondren G. et al. Chondrosarcoma of bone: an assessment of outcome. J Bone Joint Surg Am 1999; 81: 326-338.
19 Morioka H, Yabe H, Kaneko S. et al. Large chondrosarcoma of the rib invading the mediastinum and the spine. J Thorac Cardiovasc Surg 2006; 132: 986-987.
20 Bessler W, Egloff B. Dedifferentiation of chrondrosarcomas (author's transl). Arch Orthop Trauma Surg 1979; 94: 99-104.
21 Smith MC, Sherman DM. Musculoskeletal System. In Goat Medicine. 2nd ed. Ames, Iowa: Wiley-Blackwell; 2009. p 85-162.
22 Hancock RB, Rashmir-Raven AM, Thomas MW. et al. What is your diagnosis? A large, oval, radiolucent defect in the proximolateral portion of the humerus. J Am Vet Med Assoc 2000; 217: 823-824.
23 Altmaier KR, Sherman DM, Schelling SH. et al. Osteomyelitis and disseminated infection caused by Corynebacterium renale in a goat. J Am Vet Med Assoc 1994; 204: 934-937.
24 Steinberg H, George C. Fracture-associated osteogenic sarcoma and a mandibular osteoma in two goats. J Comp Pathol 1989; 100: 453-457.
25 Roman-Muniz IN, Van Metre DC, Cruz-Arambulo Rde J. et al. What is your diagnosis? Cortical lysis, medullary sclerosis, and periosteal bony proliferation of the distal portion of the metacarpus. J Am Vet Med Assoc 2003; 222: 717-718.