Non-steroidal anti-inflammatory drugs inhibit bone healing: A review

S. Barry

doi:10.3415/VCOT-10-01-0017

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 2010; 23(06): 385-392
DOI: 10.3415/VCOT-10-01-0017

Review Article

Schattauer GmbH

Non-steroidal anti-inflammatory drugs inhibit bone healing: A review

S. Barry

¹Washington State University, Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, Pullman, Washington, USA

› Author Affiliations

Abstract

Summary

The ability of non-steroidal anti-inflammatory drugs (NSAID) to inhibit bone healing has been established in experimental animal models using mice, rats, and rabbits. The mechanism of action is largely unknown but stems from prostaglandin inhibition and is likely multifactorial. In human medicine NSAID are known to prevent heterotopic ossification, however the clinical importance of their effects on bone healing remains controversial. Although a small handful of reports suggest that NSAID suppress bone healing in dogs and horses, there is little published information to direct veterinary practice in domestic species.

Keywords

Non-steroidal anti-inflammatory drugs - NSAID - bone healing

Full Text

References

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