Synovial fluid D-dimer concentration in horses with osteochondritis dissecans and osteoarthritis

T. Ribera; L. Monreal; M. A. Delgado; J. Ríos; M. Prades

doi:10.3415/VCOT-11-08-0110

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 2013; 26(01): 54-60
DOI: 10.3415/VCOT-11-08-0110

Original Research

Schattauer GmbH

Synovial fluid D-dimer concentration in horses with osteochondritis dissecans and osteoarthritis

Authors

T. Ribera

¹Servei de Cirurgia Equina, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Spain
L. Monreal

²Servei de Medicina Interna Equina, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Spain
M. A. Delgado

²Servei de Medicina Interna Equina, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Spain
J. Ríos

³Laboratory of Biostatistics & Epidemiology, Facultat de Medicina, Universitat Autònoma de Barcelona, and Statistics & Methodology Support Unit, IDIBAPS, Hospital Clínic, Barcelona, Spain
M. Prades

¹Servei de Cirurgia Equina, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Spain

Abstract

Summary

Objective: To assess the synovial fibrinolytic pathway activation in adult horses with developmental and degenerative arthropathies such as osteochondritis dissecans (OCD) and osteoarthritis (OA) by measuring synovial D-dimer concentrations.

Methods: Prospective observational clinical study of horses admitted for OCD or OA. Synovial fluid was collected during lameness examination or prior to the surgical procedure, and D-dimer concentration and routine synovial fluid analysis were performed.

Results: Fifty-eight horses (14 with OCD, 10 with OA and 34 controls) were included in this study. Synovial D-dimer concentrations of horses with OCD and OA were both higher when compared with controls, but were only significantly different in horses with OCD (p = 0.005). However, no statistical differences were observed when comparing synovial D-dimer concentrations from the OCD horses with the OA-affected horses (p = 0.444).

Clinical significance: Activation of coagulation and fibrinolysis play a role in the pathophysiology of equine OCD and OA.

Keywords

Synovial fibrinolytic activity - synovial D-dimer concentration - horse - osteochondritis dissecans - osteoarthritis

Full Text

References

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