Effect of doxycycline on contra lateral canine cranial cruciate ligament rupture

D. J. F. von Pfeil; J. Sung; J. Barry; K. Hayashi; M. R. Edwards

doi:10.3415/VCOT-15-02-0034

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 2015; 28(06): 371-378
DOI: 10.3415/VCOT-15-02-0034

Original Research

Schattauer GmbH

Effect of doxycycline on contra lateral canine cranial cruciate ligament rupture

A prospective randomized clinical trial in 69 dogs

D. J. F. von Pfeil

¹Friendship Surgical Services of the Friendship Hospital for Animals, Washington, DC, USA

²Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA

,

J. Sung

³Cornell University College of Veterinary Medicine, Ithaca, NY, USA

,

J. Barry

⁴Cornell Statistical Consulting Unit, Savage Hall, Cornell University, Ithaca, NY, USA

,

K. Hayashi

³Cornell University College of Veterinary Medicine, Ithaca, NY, USA

,

M. R. Edwards

⁵Veterinary Specialists of Alaska, P.C., Anchorage, Alaska, USA

› Author Affiliations

Abstract

Summary

Objective: To evaluate whether doxycycline administered to dogs with unilateral cranial cruciate ligament rupture (Uni-CCLR) would decrease the risk of contralateral-CCLR (CoCCLR). To evaluate predictors for Co-CCLR survival. To evaluate if a predisposition of Labrador Retrievers to Co-CCLR exists when compared to other breeds.

Methods: In this prospective randomized controlled clinical trial, 69 client-owned dogs with Uni-CCLR were randomly assigned to a doxycycline (group-D: 7.5 mg/kg PO BID x 6 weeks) or non-doxycycline (group-ND: negative control). Medical and imaging data, time from Uni- to Co-CCLR and to follow-up were recorded. Statistics included chi-squared test, logistic regression, Kaplan-Meier survival analysis, log rank test, survival curves, and frailty model (p <0.05).

Results: This study included 32 dogs in group-D, and 37 dogs in group-ND. Median follow-up was 54.5 and 61 months, respectively. Contralateral CCLR occurred in 53.1% and 48.6% at medians of 20 and 11 months, respectively. Doxycycline did not significantly decrease the risk of Co-CCLR (p = 0.83). This risk was decreased by 14.2% with each year of age but increased with each increasing kilogram of body weight and each increasing degree of tibial plateau angle by 5.4% and 9.7%, respectively. Labrador Retrievers were not significantly predisposed (p = 0.37).

Clinical significance: At the dose regimen investigated doxycycline does not decrease the risk for Co-CCLR.

Keywords

Doxycycline - canine - cranial cruciate ligament rupture - tibial plateau levelling osteotomy - dog

Full Text

References

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