Intra-articular implantation of gentamicin impregnated collagen sponge causes joint inflammation and impaired renal function in dogs

Galina Hayes; Tom Gibson; Noel M. M. Moens; Stephanie Nykamp; Darren Wood; Robert Foster; Asaf Lerer

doi:10.3415/VCOT-15-05-0088

Veterinary and Comparative Orthopaedics and Traumatology, Inhaltsverzeichnis

Vet Comp Orthop Traumatol 2016; 29(02): 159-163
DOI: 10.3415/VCOT-15-05-0088

Brief Communication

Schattauer GmbH

Intra-articular implantation of gentamicin impregnated collagen sponge causes joint inflammation and impaired renal function in dogs

Galina Hayes

¹Cornell University, Ithaca, NY, USA

,

Tom Gibson

²University of Guelph, Clinical Studies, Guelph, ON, Canada

,

Noel M. M. Moens

²University of Guelph, Clinical Studies, Guelph, ON, Canada

,

Stephanie Nykamp

²University of Guelph, Clinical Studies, Guelph, ON, Canada

,

Darren Wood

²University of Guelph, Clinical Studies, Guelph, ON, Canada

,

Robert Foster

²University of Guelph, Clinical Studies, Guelph, ON, Canada

,

Asaf Lerer

²University of Guelph, Clinical Studies, Guelph, ON, Canada

› Institutsangaben

Abstract

Summary

Objective: Gentamicin impregnated collagen sponge (GICS) can be used to treat intra-articular surgical site infections. High local concentrations of gentamicin can be reached for short periods; however the collagen vehicle may persist for much longer periods. We wished to determine the effect of sponge implantation on joint inflammation and renal function.

Methods: Eighteen medium sized mixed breed research dogs of hound type were randomized to two groups; arthroscopic implantation of GICS at gentamicin dose = 6 mg/kg (n = 9) or sham operation (n = 9). Endpoints consisted of joint inflammation measured by synovial fluid cell counts and cytokine concentrations; lameness measured by force plate asymmetry indices; and renal function measured by glomerular filtration rate (GFR) study. The prevalence of lesions associated with aminoglycoside nephrotoxicity was assessed by renal biopsy and transmission electron microscopy.

Results: Gentamicin impregnated collagen sponge implantation caused joint inflammation (p <0.01), lameness (p = 0.04), and decreased GFR (p = 0.04). No difference was observed in the prevalence of renal lesions on biopsy between the treatment and control groups (p = 0.49).

Clinical significance: Gentamicin impregnated collagen sponge implantation causes joint inflammation and lameness as well as GFR reductions at the dose assessed. Gentamicin impregnated collagen sponge are not recommended for intra-articular implantation in dogs.

Keywords

Gentamicin - collagen - sponge - dogs

Volltext

Referenzen

References
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