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Vet Comp Orthop Traumatol 2016; 29(02): 159-163
DOI: 10.3415/VCOT-15-05-0088
Brief Communication
Schattauer GmbH

Intra-articular implantation of gentamicin impregnated collagen sponge causes joint inflammation and impaired renal function in dogs

Galina Hayes
1   Cornell University, Ithaca, NY, USA
,
Tom Gibson
2   University of Guelph, Clinical Studies, Guelph, ON, Canada
,
Noel M. M. Moens
2   University of Guelph, Clinical Studies, Guelph, ON, Canada
,
Stephanie Nykamp
2   University of Guelph, Clinical Studies, Guelph, ON, Canada
,
Darren Wood
2   University of Guelph, Clinical Studies, Guelph, ON, Canada
,
Robert Foster
2   University of Guelph, Clinical Studies, Guelph, ON, Canada
,
Asaf Lerer
2   University of Guelph, Clinical Studies, Guelph, ON, Canada
› Author AffiliationsThe authors received funding for this study from the Pet Trust, Ontario Veterinary College, Ontario, Canada.
Further Information

Publication History

Received: 26 May 2015

Accepted: 20 February 2015

Publication Date:
19 December 2017 (online)

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Summary

Objective: Gentamicin impregnated collagen sponge (GICS) can be used to treat intra-articular surgical site infections. High local concentrations of gentamicin can be reached for short periods; however the collagen vehicle may persist for much longer periods. We wished to determine the effect of sponge implantation on joint inflammation and renal function.

Methods: Eighteen medium sized mixed breed research dogs of hound type were randomized to two groups; arthroscopic implantation of GICS at gentamicin dose = 6 mg/kg (n = 9) or sham operation (n = 9). Endpoints consisted of joint inflammation measured by synovial fluid cell counts and cytokine concentrations; lameness measured by force plate asymmetry indices; and renal function measured by glomerular filtration rate (GFR) study. The prevalence of lesions associated with aminoglycoside nephrotoxicity was assessed by renal biopsy and transmission electron microscopy.

Results: Gentamicin impregnated collagen sponge implantation caused joint inflammation (p <0.01), lameness (p = 0.04), and decreased GFR (p = 0.04). No difference was observed in the prevalence of renal lesions on biopsy between the treatment and control groups (p = 0.49).

Clinical significance: Gentamicin impregnated collagen sponge implantation causes joint inflammation and lameness as well as GFR reductions at the dose assessed. Gentamicin impregnated collagen sponge are not recommended for intra-articular implantation in dogs.

Keywords

Gentamicin - collagen - sponge - dogs
 

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