Effects of botulinum toxin type A on healing of injured skeletal muscles

A Ramin Shokravi; Mohammad Moshref; Behnam Eslami; Farhad Aghmasheh

doi:10.4103/0970-0358.37759

Indian Journal of Plastic Surgery, Table of Contents

CC BY-NC-ND 4.0 · Indian J Plast Surg 2007; 40(02): 129-132
DOI: 10.4103/0970-0358.37759

Original Article

Association of Plastic Surgeons of India

Effects of botulinum toxin type A on healing of injured skeletal muscles

A Ramin Shokravi

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran

,

Mohammad Moshref

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran

,

Behnam Eslami

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran

,

Farhad Aghmasheh

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran

› Author Affiliations

Abstract

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ABSTRACT

Objectives: (1) Evaluation of microscopic healing of skeletal muscle fibers after injuries, especially the arrangement of new muscle fibers and scar tissue diameter in the injury region. (2) Evaluation of alterations in microscopy of the healing procedure within skeletal muscles after injury following botulinum toxin type A (BTX -A) induced muscle immobilization. Materials and Methods: The study was done on 12 white lab rabbits of either sex in a 6-month period. Results: The immobilization of skeletal muscle fibers as a result of the use of BTX-A after injury caused a qualitative increase in fibrous tissue formation in the area of injury, and the BTX-A-induced immobilization for a period of 6 months led to muscle atrophy.

KEY WORDS

botulinum toxin - skeletal muscles - wound healing

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