Indian Journal of Plastic Surgery, Table of Contents CC BY-NC-ND 4.0 · Indian J Plast Surg 2007; 40(02): 129-132DOI: 10.4103/0970-0358.37759 Original Article Association of Plastic Surgeons of India Effects of botulinum toxin type A on healing of injured skeletal muscles Authors Author Affiliations A Ramin Shokravi Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran Mohammad Moshref Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran Behnam Eslami Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran Farhad Aghmasheh Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran Recommend Article Abstract PDF Download(opens in new window) ABSTRACT Objectives: (1) Evaluation of microscopic healing of skeletal muscle fibers after injuries, especially the arrangement of new muscle fibers and scar tissue diameter in the injury region. (2) Evaluation of alterations in microscopy of the healing procedure within skeletal muscles after injury following botulinum toxin type A (BTX -A) induced muscle immobilization. Materials and Methods: The study was done on 12 white lab rabbits of either sex in a 6-month period. Results: The immobilization of skeletal muscle fibers as a result of the use of BTX-A after injury caused a qualitative increase in fibrous tissue formation in the area of injury, and the BTX-A-induced immobilization for a period of 6 months led to muscle atrophy. KEY WORDS KEY WORDSbotulinum toxin - skeletal muscles - wound healing PDF (82 kb) References 1 Rockwood C, Charles A, Green DP. Fractures in adults. Lippincott-Reven; Philadelphia, USA: 1996: p. 293-304 2 Brin MF. Botulinum toxin: Chemistry, pharmacology, toxicity andimmunology. Muscle Nerve Suppl 1997; 6: S146-68 3 Wieder JM, Mory RL. Understanding botulimun toxin, surgical anatomy of the frown, forehead and periocular Region. Dermatol Surg 1998; 24: 1172-4 4 Sherris DA, Gassner HG. Botulinum toxin to minimize facial scarring. Facial Plast Surg 2002; 18: 35-9 5 Gassner HG, Sherris DA, Otley CC. Treatment of facial wounds with botulinum toxin A improves cosmetic outcomes in primates. Plast Reconst Surg 2000; 105: 1948-55 6 Jarvinen MJ, Lehto MU. The effect of early mobilization and immobilization on the healing process following Muscle injuries. Sports Med 1993; 15: 78-89 7 Jarvinen M, Sorvani T. Healing of a crush injury in rat striated muscle. 1. Description and testing of a new method of inducing a standard injury to the calf muscles. Acta Pathol Microbial Scand A 1975; 83: 259-65 8 Ansved T, Odergren T, Borg K. Muscle fiber atrophy in leg muscles after botulinum toxin type A treatment of cervical dystonia. Neurology 1997; 48: 1440-2 9 Wyndaele JJ, Van SADromme. Muscular weakness as a side effect of Botulinum toxin injection for neurogenic detrusor over activity. Spinal Cord 2002; 40: 599-600
