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CC BY-NC-ND 4.0 · Indian J Plast Surg 2007; 40(02): 129-132
DOI: 10.4103/0970-0358.37759
Original Article
Association of Plastic Surgeons of India

Effects of botulinum toxin type A on healing of injured skeletal muscles

A Ramin Shokravi
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran
,
Mohammad Moshref
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran
,
Behnam Eslami
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran
,
Farhad Aghmasheh
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran
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Publikationsdatum:
15. Januar 2020 (online)

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ABSTRACT

Objectives: (1) Evaluation of microscopic healing of skeletal muscle fibers after injuries, especially the arrangement of new muscle fibers and scar tissue diameter in the injury region. (2) Evaluation of alterations in microscopy of the healing procedure within skeletal muscles after injury following botulinum toxin type A (BTX -A) induced muscle immobilization. Materials and Methods: The study was done on 12 white lab rabbits of either sex in a 6-month period. Results: The immobilization of skeletal muscle fibers as a result of the use of BTX-A after injury caused a qualitative increase in fibrous tissue formation in the area of injury, and the BTX-A-induced immobilization for a period of 6 months led to muscle atrophy.

KEY WORDS

botulinum toxin - skeletal muscles - wound healing
 
  • 1 Rockwood C, Charles A, Green DP. Fractures in adults. Lippincott-Reven; Philadelphia, USA: 1996: p. 293-304
    Suche in Google Scholar
  • 2 Brin MF. Botulinum toxin: Chemistry, pharmacology, toxicity andimmunology. Muscle Nerve Suppl 1997; 6: S146-68
    PubMedSuche in Google Scholar
  • 3 Wieder JM, Mory RL. Understanding botulimun toxin, surgical anatomy of the frown, forehead and periocular Region. Dermatol Surg 1998; 24: 1172-4
    PubMedSuche in Google Scholar
  • 4 Sherris DA, Gassner HG. Botulinum toxin to minimize facial scarring. Facial Plast Surg 2002; 18: 35-9
    Thieme ConnectPubMedSuche in Google Scholar
  • 5 Gassner HG, Sherris DA, Otley CC. Treatment of facial wounds with botulinum toxin A improves cosmetic outcomes in primates. Plast Reconst Surg 2000; 105: 1948-55
    CrossrefPubMedSuche in Google Scholar
  • 6 Jarvinen MJ, Lehto MU. The effect of early mobilization and immobilization on the healing process following Muscle injuries. Sports Med 1993; 15: 78-89
    CrossrefPubMedSuche in Google Scholar
  • 7 Jarvinen M, Sorvani T. Healing of a crush injury in rat striated muscle. 1. Description and testing of a new method of inducing a standard injury to the calf muscles. Acta Pathol Microbial Scand A 1975; 83: 259-65
    Suche in Google Scholar
  • 8 Ansved T, Odergren T, Borg K. Muscle fiber atrophy in leg muscles after botulinum toxin type A treatment of cervical dystonia. Neurology 1997; 48: 1440-2
    CrossrefPubMedSuche in Google Scholar
  • 9 Wyndaele JJ, Van SADromme. Muscular weakness as a side effect of Botulinum toxin injection for neurogenic detrusor over activity. Spinal Cord 2002; 40: 599-600
    CrossrefPubMedSuche in Google Scholar