PDF herunterladen
CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2012; 22(03): 155-159
DOI: 10.4103/0971-3026.107169
ORIGINAL ARTICLE

Diffusion-weighted MRI in assessment of renal dysfunction

Ankur Goyal
Department of Radiodiagnosis, All India Institute of Medical Sciences (A.I.I.M.S.), New Delhi
,
Raju Sharma
Department of Radiodiagnosis, All India Institute of Medical Sciences (A.I.I.M.S.), New Delhi
,
Ashu Bhalla
Department of Radiodiagnosis, All India Institute of Medical Sciences (A.I.I.M.S.), New Delhi
,
Shivanand Gamanagatti
Department of Radiodiagnosis, All India Institute of Medical Sciences (A.I.I.M.S.), New Delhi
,
Amlesh Seth
Department of Urology, All India Institute of Medical Sciences (A.I.I.M.S.), New Delhi
› Institutsangaben Source of Support: Nill.
› Weitere Informationen
Auch verfügbar auf
  als PDF herunterladen Lizenzen und Reprints

Abstract

Background: Diffusion-weighted magnetic resonance imaging (DW-MRI) in renal diseases is an evolving field and its potential is yet to be fully realized. Purpose: To study the relationship between apparent diffusion coefficient (ADC) values of renal parenchyma and serum markers of renal function and stage of chronic kidney disease (CKD). Materials and Methods: A retrospective review was performed of all adult patients who underwent DW-MRI (at b-values of 0 and 500 s/mm2 ) for renal lesions from January 2009 to September 2010 and revealed 88 patients, of which 22 patients had renal dysfunction and 66 had normal renal function. Of these 22, 15 patients were known cases of CKD and were staged depending on disease severity. ADC values were determined for renal parenchyma and compared. Receiver operating characteristic (ROC) curves were drawn to establish cut-off ADC values. Pearson′s correlation coefficient (R) was calculated between ADC and renal function parameters. Results: ADC values in patients with renal dysfunction were significantly lower than in patients with normal renal function (2.1133 ± 0.2851 vs. 2.3198 ± 0.1246 (×10-3 mm2/s)). ADC values lower than 2.0354 (×10-3 mm2/s) were seen only with renal dysfunction and higher than 2.4516 (×10-3 mm2/s) were seen only with normal function. There was significant inverse correlation between ADC and serum creatinine (R = -0.530), blood urea (R= -0.502), and significant linear correlation (R = 0.784) with estimated glomerular filtration rate (eGFR). ADC values showed a statistically significant decreasing trend with increasing stage of CKD. Conclusion: ADC values may serve as an additional marker for the presence and degree of renal dysfunction.

Keywords

Apparent diffusion coefficient - chronic kidney disease - diffusion-weighted MRI - kidney - renal dysfunction


Publikationsverlauf

Artikel online veröffentlicht:
04. Oktober 2021

© 2012. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 

  • References

  • 1 Agarwal SK, Srivastava RK. Chronic kidney disease in India: Challenges and solutions. Nephron Clin Pract 2009;111:c197-203.
  • 2 Bauer JH, Brooks CS, Burch RN. Clinical appraisal of creatinine clearance as a measurement of glomerular filtration rate. Am J Kidney Dis 1982;2:337-46.
  • 3 Prigent A. Monitoring renal function and limitations of renal function tests. Semin Nucl Med 2008;38:32-46.
  • 4 Chandarana H, Lee VS. Renal functional MRI: Are we ready for clinical application? AJR Am J Roentgenol 2009;192:1550-7.
  • 5 Squillaci E, Manenti G, Di Stefano F, Miano R, Strigari L, Simonetti G. Diffusion weighted MR imaging in the evaluation of renal tumours. J Exp Clin Cancer Res 2004;23:39-45.
  • 6 Cova M, Squillaci E, Stacul F, Manenti G, Gava S, Simonetti G, et al. Diffusion weighted MRI in the evaluation of renal lesions: Preliminary results. Br J Radiol 2004;77:851-7.
  • 7 Yoshikawa T, Kawamitsu H, Mitchell DG, Ohno Y, Ku Y, Seo Y, et al. ADC measurement of abdominal organs and lesions using parallel imaging technique. AJR Am J Roentgenol 2006;187:1521-30.
  • 8 Zhang J, Tehrani YM, Wang L, Ishill NM, Schwartz LH, Hricak H. Renal masses: Characterization with diffusion-weighted MR imaging-A preliminary experience. Radiology 2008;247:458-64.
  • 9 Taouli B, Thakur R, Mannelli L, Babb JS, Kim S, Hecht EM, et al. Renal lesions: Characterization with diffusion-weighted imaging versus contrast-enhanced MR imaging. Radiology 2009;251:398-407.
  • 10 Kilickesmez O, Inci E, Atilla S, Tasdelen N, Yetimoglu B, Yencilek F, et al. Diffusion-weighted imaging of the renal and adrenal lesions. J Comput Assist Tomogr 2009;33:828-33.
  • 11 Sandrasegaran K, Sundaram CP, Ramaswamy R, Akisik FM, Rydberg MR, Lin C, et al. Usefulness of diffusion-weighted imaging in the evaluation of renal masses. AJR Am J Roentgenol 2010;194:438-45.
  • 12 Namimoto T, Yamashita Y, Mitsuzaki K, Nakayama Y, Tang Y, Takahashi M. Measurement of the apparent diffusion coefficient in diffuse renal disease by diffusion-weighted echo-planar MR imaging. J Magn Reson Imaging 1999;9:832-37.
  • 13 Thoeny HC, De Keyzer F, Oyen RH, Peeters RR. Diffusion-weighted MR imaging of kidneys in healthy volunteers and patients with parenchymal diseases-initial experience. Radiology 2005;235:911-7.
  • 14 Xu Y, Wang X, Jiang X. Relationship between the renal apparent diffusion coefficient and glomerular filtration rate: Preliminary experience. J Magn Reson Imaging 2007;26:678-81.
  • 15 Xu X, Fang W, Ling H, Chai W, Chen K. Diffusion-weighted MR imaging of kidneys in patients with chronic kidney disease: Initial study. Eur Radiol 2010;20:978-83.
  • 16 Toya R, Naganawa S, Kawai H, Ikeda M. Correlation between estimated glomerular filtration rate (eGFR) and apparent diffusion coefficient (ADC) values of the kidneys. Magn Reson Med Sci 2010;9:59-64.
  • 17 Chan JH, Tsui EY, Luk SH, Fung SL, Cheung YK, Chan MS, et al. MR diffusion-weighted imaging of kidney-differentiation between hydronephrosis and pyonephrosis. Clin Imag 2001;25:110-3.
  • 18 Verswijvel G, Vandecaveye V, Gelin G, Vandevenne J, Grieten M, Horvath M, et al. Diffusion-weighted MR imaging in the evaluation of renal infection: Preliminary results. JBR-BTR 2002;85:100-3.
  • 19 Goyal A, Gadodia A, Sharma R. Xanthogranulomatous pyelonephritis: An uncommon pediatric renal mass. Pediatr Radiol 2010;40:1962-3.
  • 20 Knochel JP. Biochemical alterations in advanced uremic failure. In: Jacobson HR, Striker GE, Klahr S, editors. The Principles and Practice of Nephrology, 1 st ed. Philadelphia: BC Decker; 1991. p. 682-4.
  • 21 National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis 2002;39:S1-266.
  • 22 Fukuda Y, Ohashi I, Hanafusa K, Nakagawa T, Ohtani S, Annaka Y, et al. Anisotropic diffusion in kidney: Apparent diffusion coefficient measurements for clinical use. J Magn Reson Imaging 2000;11:156-60.