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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2015; 25(03): 284-287
DOI: 10.4103/0971-3026.161459
Musculoskeletal Radiology

A rare case of extra nodal Rosai-Dorfman disease with isolated multifocal osseous manifestation

Maharshi H Patel
Department of Radiology, Musculoskeletal and Body MRI Division, University of Arkansas for Medical Sciences, Arkansas, USA
,
Kedar R Jambhekar
Department of Radiology, Musculoskeletal and Body MRI Division, University of Arkansas for Medical Sciences, Arkansas, USA
,
Tarun Pandey
Department of Radiology, Musculoskeletal and Body MRI Division, University of Arkansas for Medical Sciences, Arkansas, USA
,
Roopa Ram
Department of Radiology, Musculoskeletal and Body MRI Division, University of Arkansas for Medical Sciences, Arkansas, USA
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai-Dorfman disease is a non-neoplastic condition which typically presents as massive, bilateral cervical lymphadenopathy and can involve multiple extranodal organ systems such as skin, eyes, and upper respiratory tract in about 28% cases. Bone lesions in association with nodal disease are seen in less than 10% cases. Isolated bone involvement as the only manifestation of SHML is extremely rare, with less than 50 cases reported in the literature. We report a very uncommon case of Rosai-Dorfman disease with isolated multifocal osseous involvement as the only presenting feature, involving about 10 different sites with no lymphadenopathy or other organ system involvement.

Keywords

Extra nodal - histiocytes - Rosai-Dorfman


Publication History

Article published online:
30 July 2021

© 2015. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Demicco EG, Rosenberg AE, Björnsson J, Rybak LD, Unni KK, Nielsen GP. Primary Rosai-Dorfman disease of bone: A clinicopathologic study of 15 cases. Am J Surg Pathol 2010;34:1324-33.
  • 2 Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: A pseudolymphomatous benign disorder. Analysis of 34 cases. Cancer 1972;30:1174-88.
  • 3 Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Review of the entity. Semin Diagn Pathol 1990;7:19-73.
  • 4 Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity. Arch Pathol 1969;87:63-70.
  • 5 Walczak BE, Halperin DM, Bdeir RW, Irwin RB. Orthopaedic case of the month: A 50-year-old woman with persistent knee pain. Clin Orthop Relat Res 2011;469:3527-32.
  • 6 Dean EM, Wittig JC, Vilalobos C, Garcia RA. A 16-year-old boy with multifocal, painless osseous lesions. Clin Orthop Relat Res 2012;470:2640-5.
  • 7 Loh SY, Tan KB, Wong YS, Lee YS. Rosai-Dorfman disease of the triquetrum without lymphadenopathy. A case report. J Bone Joint Surg Am 2004;86-A:595-8.
  • 8 Patterson FR, Rooney MT, Damron TA, Vermont AI, Hutchison RE. Sclerotic lesion of the tibia without involvement of lymph nodes. Report of an unusual case of Rosai-Dorfman disease. J Bone Joint Surg Am 1997;79:911-6.
  • 9 Sundaram C, Uppin Shantveer G, Chandrashekar P, Prasad VB, Umadevi M. Multifocal osseous involvement as the sole manifestation of Rosai-Dorfman disease. Skeletal Radiol 2005;34:658-64.
  • 10 Tripathy K, Misra A, Sahu AK, Patnaik K. Extranodal Rosai-Dorfman disease in a carpal bone. Indian J Orthop 2012;46:487-9.